6TDA
 
 | | Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome | | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC58, ... | | 著者 | Wagner, F.R, Dienemann, C, Wang, H, Stuetzer, A, Tegunov, D, Urlaub, H, Cramer, P. | | 登録日 | 2019-11-08 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (15 Å) | | 主引用文献 | Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome.
Nature, 579, 2020
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3SCZ
 | | Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase | | 分子名称: | HYPOXANTHINE, Purine nucleoside phosphorylase | | 著者 | de Azevedo Jr, W.F, Caceres, R.A, Timmers, L.F.S.M, Ducati, R.G, Rosado, L.A, Basso, L.A, Santos, D.S. | | 登録日 | 2011-06-08 | | 公開日 | 2012-06-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase
To be Published
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1YRY
 | | Crystal structure of human PNP complexed with MESG | | 分子名称: | 7-METHYL-6-THIO-GUANOSINE, Purine nucleoside phosphorylase, SULFATE ION | | 著者 | Silva, R.G, Pereira, J.H, Canduri, F, Basso, L.A, de Azevedo Jr, W.F, Santos, D.S. | | 登録日 | 2005-02-05 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine
Arch.Biochem.Biophys., 442, 2005
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6JR1
 | | Crystal structure of the human nucleosome phased with 16 selenium atoms | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | | 著者 | Saotome, M, Horikoshi, N, Urano, K, Kujirai, T, Yuzurihara, H, Kurumizaka, H, Kagawa, W. | | 登録日 | 2019-04-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure determination of the nucleosome core particle by selenium SAD phasing.
Acta Crystallogr D Struct Biol, 75, 2019
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6JR0
 | | Crystal structure of the human nucleosome phased with 12 selenium atoms | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | | 著者 | Saotome, M, Horikoshi, N, Urano, K, Kujirai, T, Yuzurihara, H, Kurumizaka, H, Kagawa, W. | | 登録日 | 2019-04-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure determination of the nucleosome core particle by selenium SAD phasing.
Acta Crystallogr D Struct Biol, 75, 2019
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8YNY
 | | Structure of Cas9-sgRNA ribonucleoprotein bound to nucleosome | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (17-mer), DNA (175-mer), ... | | 著者 | Nagamura, R, Kujirai, T, Kusakizako, T, Hirano, H, Kurumizaka, H, Nureki, O. | | 登録日 | 2024-03-12 | | 公開日 | 2025-01-22 | | 実験手法 | ELECTRON MICROSCOPY (4.52 Å) | | 主引用文献 | Structural insights into how Cas9 targets nucleosomes.
Nat Commun, 15, 2024
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5B2J
 | | Human nucleosome containing CpG methylated DNA | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Fujii, Y, Wakamori, M, Umehara, T, Yokoyama, S. | | 登録日 | 2016-01-18 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.
Febs Open Bio, 6, 2016
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5T3K
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8XJV
 | | Structural basis for the linker histone H5-nucleosome binding and chromatin compaction | | 分子名称: | DNA, Histone H2A, Histone H2B 1.1, ... | | 著者 | Li, W.Y, Song, F, Zhu, P. | | 登録日 | 2023-12-22 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for linker histone H5-nucleosome binding and chromatin fiber compaction.
Cell Res., 34, 2024
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9J0P
 | | Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC2-nuc) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | Naganuma, M, Kujirai, T, Ehara, H, Uejima, T, Ito, T, Goto, M, Aoki, M, Henmi, M, Miyamoto-Kohno, S, Shirouzu, M, Kurumizaka, H, Sekine, S. | | 登録日 | 2024-08-02 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome.
Sci Adv, 11, 2025
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9J0N
 | | Paused elongation complex of mammalian RNA polymerase II with nucleosome (PEC2-nuc) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | Naganuma, M, Kujirai, T, Ehara, H, Uejima, T, Ito, T, Goto, M, Aoki, M, Henmi, M, Miyamoto-Kohno, S, Shirouzu, M, Kurumizaka, H, Sekine, S. | | 登録日 | 2024-08-02 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome.
Sci Adv, 11, 2025
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9J0O
 | | Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC1-nuc) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | Naganuma, M, Kujirai, T, Ehara, H, Uejima, T, Ito, T, Goto, M, Aoki, M, Henmi, M, Miyamoto-Kohno, S, Shirouzu, M, Kurumizaka, H, Sekine, S. | | 登録日 | 2024-08-02 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural insights into promoter-proximal pausing of RNA polymerase II at +1 nucleosome.
Sci Adv, 11, 2025
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6JOU
 | | Crystal structure of the human nucleosome containing H2A.Z.1 S42R | | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... | | 著者 | Horikoshi, N, Sato, K, Mizukami, Y, Kurumizaka, H. | | 登録日 | 2019-03-23 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo.
Biochem.Biophys.Res.Commun., 515, 2019
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5B2I
 | | Human nucleosome containing CpG unmethylated DNA | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Fujii, Y, Wakamori, M, Umehara, T, Yokoyama, S. | | 登録日 | 2016-01-16 | | 公開日 | 2016-06-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of human nucleosome core particle containing enzymatically introduced CpG methylation.
Febs Open Bio, 6, 2016
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8HXY
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6T90
 | | OCT4-SOX2-bound nucleosome - SHL-6 | | 分子名称: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-10-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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1YVX
 | | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | | 分子名称: | 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | | 登録日 | 2005-02-16 | | 公開日 | 2005-03-22 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
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9GD3
 | | Structure of a mononucleosome bound by one copy of Chd1 with the DBD on the exit-side DNA. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | | 登録日 | 2024-08-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
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8V7L
 | | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | | 登録日 | 2023-12-04 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
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8GXQ
 | | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | | 登録日 | 2022-09-21 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (5.04 Å) | | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
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8GXS
 | | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | | 登録日 | 2022-09-21 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | | 主引用文献 | Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
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1SQ6
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5TBV
 | | Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase complexed with tubercidin | | 分子名称: | '2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, DIMETHYL SULFOXIDE, Purine nucleoside phosphorylase, ... | | 著者 | Faheem, M, Torini, J.R, Romanello, L, Brandao-Neto, J, Pereira, H.M. | | 登録日 | 2016-09-13 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase
To Be Published
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9J8O
 | | Cryo-EM structure of BAF-Lamin A/C IgF-H1-nucleosome complex | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H1.1, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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9J8N
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (Low mobility complex) | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (7.14 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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