PDB: 238582 件ウェブページステータス検索Chemie searchBIRD

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6N5U	Crystal structure of Arabidopsis thaliana ScoI with copper bound 分子名称: COPPER (I) ION, Protein SCO1 homolog 1, mitochondrial 著者 Lisa, M.N, Giannini, E, Llases, M.E, Alzari, P.M, Vila, A.J. 登録日 2018-11-22 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Arabidopsis thaliana Hcc1 is a Sco-like metallochaperone for CuAassembly in Cytochrome c Oxidase. Febs J., 287, 2020
8E0G	Re-refined model of active mu-opioid receptor (PDB 5c1m) as an adduct with BU72 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, HEXAETHYLENE GLYCOL, ... 著者 Munro, T.A. 登録日 2022-08-09 公開日 2023-10-18 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Reanalysis of a mu opioid receptor crystal structure reveals a covalent adduct with BU72. Bmc Biol., 21, 2023
7SQM	Discovery and Preclinical Pharmacology of INE963, A Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cure in Uncomplicated Malaria 分子名称: 1-[(4S)-5-(2,4-difluorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-4-methylpiperidin-4-amine, GLYCEROL, Serine/threonine-protein kinase haspin 著者 Shu, W, Yokokawa, F. 登録日 2021-11-05 公開日 2021-12-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Failure of artesunate-mefloquine combination therapy for uncompli-cated Plasmodium falciparum malaria in southern Cambodia. Malar. J., 2009, 8, 10, 2009
2YEX	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors 分子名称: 5-METHYL-8-(1H-PYRROL-2-YL)[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A. 登録日 2011-03-31 公開日 2012-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
2YER	Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors 分子名称: 1,2-ETHANEDIOL, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, ... 著者 Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A, Otterbein, L. 登録日 2011-03-30 公開日 2012-03-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
5C04	Crystal structure of the F37H mutant AhpE from Mycobacterium tuberculosis 分子名称: Putative peroxiredoxin MT2298 著者 Pallo, A, Dufe, V.T, Messens, J. 登録日 2015-06-12 公開日 2016-07-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The active site architecture in peroxiredoxins: a case study on Mycobacterium tuberculosis AhpE. Chem.Commun.(Camb.), 52, 2016
6S0M	Structural and dynamic studies provide insights into specificity and allosteric regulation of Ribonuclease AS, a key enzyme in mycobacterial virulence 分子名称: 3'-5' exoribonuclease, MAGNESIUM ION, RNA (5'-R(P*G)-3') 著者 Berisio, R, Romano, M. 登録日 2019-06-17 公開日 2019-08-28 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and dynamic studies provide insights into specificity and allosteric regulation of ribonuclease as, a key enzyme in mycobacterial virulence. J.Biomol.Struct.Dyn., 38, 2020
6NKQ	The structure of bovine beta-lactoglobulin in novel crystals grown at pH 3.8 分子名称: Beta-lactoglobulin, CALCIUM ION 著者 McPherson, A. 登録日 2019-01-07 公開日 2019-01-23 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of bovine beta-lactoglobulin in crystals grown at pH 3.8 exhibiting novel threefold twinning. Acta Crystallogr.,Sect.F, 75, 2019
1BHC	BOVINE PANCREATIC TRYPSIN INHIBITOR CRYSTALLIZED FROM THIOCYANATE 分子名称: BOVINE PANCREATIC TRYPSIN INHIBITOR, THIOCYANATE ION 著者 Hamiaux, C, Prange, T. 登録日 1998-06-05 公開日 1998-09-16 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The decameric structure of bovine pancreatic trypsin inhibitor (BPTI) crystallized from thiocyanate at 2.7 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
7BUP	Crystal structure of PCNA from pathogenic yeast Candida albicans 分子名称: Proliferating cell nuclear antigen 著者 sundaram, R, Vasudevan, D. 登録日 2020-04-07 公開日 2021-02-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural analyses of PCNA from the fungal pathogen Candida albicans identify three regions with species-specific conformations. Febs Lett., 595, 2021
1BDK	AN NMR, CD, MOLECULAR DYNAMICS, AND FLUOROMETRIC STUDY OF THE CONFORMATION OF THE BRADYKININ ANTAGONIST B-9340 IN WATER AND IN AQUEOUS MICELLAR SOLUTIONS 分子名称: bradykinin antagonist B-9340 著者 Sejbal, J, Kotovych, G, Cann, J.R, Stewart, J.M, Gera, L. 登録日 1995-07-28 公開日 1995-12-07 最終更新日 2024-06-05 実験手法 SOLUTION NMR 主引用文献 An NMR, CD, molecular dynamics, and fluorometric study of the conformation of the bradykinin antagonist B-9340 in water and in aqueous micellar solutions. J.Med.Chem., 39, 1996
2VXW	Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-RANTES 分子名称: C-C MOTIF CHEMOKINE 5 著者 Jin, H, Li, P, LiWang, P.J. 登録日 2008-07-12 公開日 2008-07-29 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and Functional Studies of the Potent Anti-HIV Chemokine Variant P2-Rantes. Proteins, 78, 2010
6KFY	SufS from Bacillus subtilis in a resting state at 1.96 angstrom resolution 分子名称: Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... 著者 Nakamura, R, Takahashi, Y, Fujishiro, T. 登録日 2019-07-09 公開日 2020-07-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J., 2022
7E3U	Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU 分子名称: 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, D-hydantoinase/dihydropyrimidinase, ZINC ION 著者 Yang, Y.C, Luo, R.H, Huang, Y.H, Huang, C.Y, Lin, E.S. 登録日 2021-02-09 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.159 Å) 主引用文献 Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5-Aminouracil: A Different Binding Mode from the Anticancer Drug 5-Fluorouracil. Bioinorg Chem Appl, 2022, 2022
7E50	Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI 分子名称: AAEL006007-PA, GLYCEROL, Plasminogen, ... 著者 Varsha, A.W, Jobichen, C, Mok, Y.K. 登録日 2021-02-16 公開日 2022-02-16 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci., 31, 2022
6KFZ	SufS from Bacillus subtilis, soaked with L-cysteine for 90 sec at 1.96 angstrom resolution 分子名称: Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-L-CYSTEINE 著者 Nakamura, R, Takahashi, Y, Fujishiro, T. 登録日 2019-07-09 公開日 2019-10-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. Febs J., 287, 2020
6KUC	Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 2) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein 著者 Rathore, I, Mishra, V, Bhaumik, P. 登録日 2019-08-31 公開日 2020-05-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway. Febs J., 288, 2021
6KUD	Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 3) 分子名称: GLYCEROL, HAP protein 著者 Rathore, I, Mishra, V, Bhaumik, P. 登録日 2019-08-31 公開日 2020-05-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway. Febs J., 288, 2021
6KUB	Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 1) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HAP protein 著者 Rathore, I, Mishra, V, Bhaumik, P. 登録日 2019-08-31 公開日 2020-05-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway. Febs J., 288, 2021
6L0I	Crystal structure of dihydroorotase in complex with malate at pH6.5 from Saccharomyces cerevisiae 分子名称: (2S)-2-hydroxybutanedioic acid, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
6L0F	Crystal structure of dihydroorotase in complex with 5-Aminouracil from Saccharomyces cerevisiae 分子名称: 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, Dihydroorotase, ZINC ION 著者 Guan, H.H, Huang, Y.H, Huang, C.Y, Chen, C.J. 登録日 2019-09-26 公開日 2020-12-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.26 Å) 主引用文献 Structural basis for the interaction modes of dihydroorotase with the anticancer drugs 5-fluorouracil and 5-aminouracil. Biochem.Biophys.Res.Commun., 551, 2021
7F2N	Crystal structure of SSB from Klebsiella pneumonia. 分子名称: Single-stranded DNA-binding protein 著者 Lin, E.S, Huang, Y.H, Huang, C.Y. 登録日 2021-06-11 公開日 2021-11-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Characterization of the Chimeric PriB-SSBc Protein. Int J Mol Sci, 22, 2021
6TXW	V30G Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. 登録日 2020-01-14 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.153 Å) 主引用文献 Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
6TXV	A25T Transthyretin structure in complex with Tolcalpone 分子名称: Tolcapone, Transthyretin 著者 Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. 登録日 2020-01-14 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
6S0S	The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex with nickel, ribostamycin B and 2-oxoglutarate 分子名称: 2-OXOGLUTARIC ACID, CHLORIDE ION, Kanamycin B dioxygenase, ... 著者 Mrugala, B, Porebski, P.J, Niedzialkowska, E, Minor, W, Borowski, T. 登録日 2019-06-18 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates. Febs J., 288, 2021

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