6SFR
| SOS1 in Complex with Inhibitor BI-68BS | 分子名称: | 6,7-dimethoxy-~{N}-[(1~{R})-1-phenylethyl]quinazolin-4-amine, IMIDAZOLE, Son of sevenless homolog 1 | 著者 | Kessler, D, Fischer, G, Ramharter, J. | 登録日 | 2019-08-02 | 公開日 | 2020-08-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.917 Å) | 主引用文献 | BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discov, 11, 2021
|
|
6SCM
| SOS1 in Complex with Inhibitor BI-3406 | 分子名称: | 1,2-ETHANEDIOL, IMIDAZOLE, Son of sevenless homolog 1, ... | 著者 | Kessler, D, Fischer, G, Ramharter, J. | 登録日 | 2019-07-24 | 公開日 | 2020-08-26 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | 主引用文献 | BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer Discov, 11, 2021
|
|
6SMW
| A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with pemetrexed | 分子名称: | 1,2-ETHANEDIOL, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Ruszkowski, M, Sekula, B, Dauter, Z. | 登録日 | 2019-08-23 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9, 2019
|
|
3GTU
| |
6SMR
| A. thaliana serine hydroxymethyltransferase isoform 4 (AtSHMT4) in complex with methotrexate | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, METHOTREXATE, ... | 著者 | Ruszkowski, M, Sekula, B, Dauter, Z. | 登録日 | 2019-08-22 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9, 2019
|
|
6TV7
| Crystal structure of rsGCaMP in the OFF state (illuminated) | 分子名称: | CALCIUM ION, SODIUM ION, rsGCaMP | 著者 | Janowski, R, Fuenzalida-Werner, J.P, Mishra, K, Stiel, A.C, Niessing, D. | 登録日 | 2020-01-09 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging. Nat.Biotechnol., 2021
|
|
6SMN
| A. thaliana serine hydroxymethyltransferase isoform 2 (AtSHMT2) in complex with methotrexate | 分子名称: | 1,2-ETHANEDIOL, METHOTREXATE, SERINE, ... | 著者 | Ruszkowski, M, Sekula, B, Dauter, Z. | 登録日 | 2019-08-22 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. Sci Rep, 9, 2019
|
|
7KL7
| |
7KL6
| Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase | 分子名称: | (3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid, Phosphoribosyltransferase, SULFATE ION | 著者 | Guddat, L.W, Keough, D.T. | 登録日 | 2020-10-29 | 公開日 | 2021-05-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections. J.Med.Chem., 64, 2021
|
|
2XQN
| Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal domain of actin-like protein Arp7A | 分子名称: | ACTIN-LIKE PROTEIN 7A, ENABLED HOMOLOG, TESTIN, ... | 著者 | Knowles, P.P, Briggs, D.C, Murray-Rust, J, McDonald, N.Q. | 登録日 | 2010-09-03 | 公開日 | 2011-01-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J. Biol. Chem., 286, 2011
|
|
3B6S
| Crystal Structure of hla-b*2705 Complexed with the Citrullinated Vasoactive Intestinal Peptide Type 1 Receptor (vipr) Peptide (residues 400-408) | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-27 alpha chain, ... | 著者 | Beltrami, A, Rossmann, M, Fiorillo, M.T, Sorrentino, R, Saenger, W, Ziegler, A, Uchanska-Ziegler, A. | 登録日 | 2007-10-29 | 公開日 | 2008-07-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Citrullination-dependent Differential Presentation of a Self-peptide by HLA-B27 Subtypes. J.Biol.Chem., 283, 2008
|
|
3BIF
| 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE EMPTY 6-PF-2K ACTIVE SITE | 分子名称: | PHOSPHATE ION, PROTEIN (6-PHOSPHOFRUCTO-2-KINASE/ FRUCTOSE-2,6-BISPHOSPHATASE), SUCCINIC ACID, ... | 著者 | Yuen, M.H, Hasemann, C.A. | 登録日 | 1999-05-05 | 公開日 | 1999-09-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Biochemistry, 38, 1999
|
|
6FLL
| |
6FL5
| Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution | 分子名称: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... | 著者 | Giardina, G, Cutruzzola, F, Lucchi, R. | 登録日 | 2018-01-25 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. FEBS J., 285, 2018
|
|
1G9U
| CRYSTAL STRUCTURE OF YOPM-LEUCINE RICH EFFECTOR PROTEIN FROM YERSINIA PESTIS | 分子名称: | ACETATE ION, CALCIUM ION, MERCURY (II) ION, ... | 著者 | Evdokimov, A.G, Anderson, D.E, Routzahn, K.M, Waugh, D.S. | 登録日 | 2000-11-28 | 公開日 | 2001-10-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit. J.Mol.Biol., 312, 2001
|
|
2CBM
| Crystal structure of the apo-form of a neocarzinostatin mutant evolved to bind testosterone. | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, NEOCARZINOSTATIN | 著者 | Drevelle, A, Graille, M, Heyd, B, Sorel, I, Ulryck, N, Pecorari, F, Desmadril, M, Van Tilbeurgh, H, Minard, P. | 登録日 | 2006-01-06 | 公開日 | 2006-03-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structures of in Vitro Evolved Binding Sites on Neocarzinostatin Scaffold Reveal Unanticipated Evolutionary Pathways. J.Mol.Biol., 358, 2006
|
|
3DTX
| Crystal structure of HLA-B*2705 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408) | 分子名称: | Beta-2-microglobulin, Double citrullinated vasoactive intestinal polypeptide receptor, MHC class I antigen (Fragment) | 著者 | Beltrami, A, Gabdulkhakov, A, Rossmann, M, Ziegler, A, Uchanska-Ziegler, B, Saenger, W. | 登録日 | 2008-07-16 | 公開日 | 2009-05-05 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Citrullination-and mhc polymorphism-dependent conformational changes of a self peptide To be Published
|
|
3HCV
| Crystal structure of HLA-B*2709 complexed with the double citrullinated vasoactive intestinal peptide type 1 receptor (VIPR) peptide (residues 400-408) | 分子名称: | Beta-2-microglobulin, DOUBLE CITRULLINATED VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR, HLA class I histocompatibility antigen, ... | 著者 | Beltrami, A, Gabdulkhakov, A, Rossmann, M, Ziegler, A, Uchanska-Ziegler, B, Saenger, W. | 登録日 | 2009-05-06 | 公開日 | 2009-06-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Citrullination-and mhc polymorphism-dependent conformational changes of
a self peptide To be Published
|
|
1IOP
| INCORPORATION OF A HEMIN WITH THE SHORTEST ACID SIDE-CHAINS INTO MYOGLOBIN | 分子名称: | 6,7-DICARBOXYL-1,2,3,4,5,8-HEXAMETHYLHEMIN, CYANIDE ION, MYOGLOBIN, ... | 著者 | Igarashi, N, Neya, S, Funasaki, N, Tanaka, N. | 登録日 | 1997-12-12 | 公開日 | 1998-04-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and function of 6,7-dicarboxyheme-substituted myoglobin Biochemistry, 37, 1998
|
|
5KYJ
| Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core | 分子名称: | (6~{R})-5-(5-fluoranyl-2-methoxy-pyrimidin-4-yl)-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazole, Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-07-21 | 公開日 | 2016-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorg.Med.Chem.Lett., 26, 2016
|
|
5KYA
| Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core | 分子名称: | Oxysterols receptor LXR-beta, Retinoic acid receptor RXR-beta, [2-[(6~{R})-2-(3-methylsulfonylphenyl)-6-propan-2-yl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-4-(trifluoromethyl)pyrimidin-5-yl]methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-07-21 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core. Bioorg.Med.Chem.Lett., 26, 2016
|
|
2WQ2
| |
2WQ3
| |
2WPZ
| GCN4 leucine zipper mutant with two VxxNxxx motifs coordinating chloride | 分子名称: | CHLORIDE ION, GENERAL CONTROL PROTEIN GCN4 | 著者 | Zeth, K, Hartmann, M.D, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B. | 登録日 | 2009-08-12 | 公開日 | 2009-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | A Coiled-Coil Motif that Sequesters Ions to the Hydrophobic Core. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
2WPQ
| Salmonella enterica SadA 479-519 fused to GCN4 adaptors (SadAK3, in- register fusion) | 分子名称: | CHLORIDE ION, NITRATE ION, TRIMERIC AUTOTRANSPORTER ADHESIN FRAGMENT | 著者 | Hartmann, M.D, Hernandez Alvarez, B, Albrecht, R, Zeth, K, Lupas, A.N. | 登録日 | 2009-08-09 | 公開日 | 2009-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A Coiled-Coil Motif that Sequesters Ions to the Hydrophobic Core. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|