Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8FBC
DownloadVisualize
BU of 8fbc by Molmil
Crystal structure of P450T2
分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Pereira, J.H, Huang, J, Keasling, J, Adams, P.D.
登録日2022-11-29
公開日2023-05-10
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Complete integration of carbene-transfer chemistry into biosynthesis.
Nature, 617, 2023
8FID
DownloadVisualize
BU of 8fid by Molmil
Crystal Structure of Erwinia tracheiphila CYP114 in complex with ent-kaurenoic acid (Crystal Form 2)
分子名称: (8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-oic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Stewart Jr, C.E, Nagel, R.
登録日2022-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8FIB
DownloadVisualize
BU of 8fib by Molmil
Crystal Structure of Erwinia tracheiphila CYP114
分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Stewart Jr, C.E, Nagel, R.
登録日2022-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G36
DownloadVisualize
BU of 8g36 by Molmil
Crystal structure of F182L-CYP199A4 in complex with terephthalic acid
分子名称: CHLORIDE ION, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Lee, J.H.Z, Bruning, J.B, Bell, S.G.
登録日2023-02-06
公開日2023-05-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.
J.Am.Chem.Soc., 145, 2023
8G35
DownloadVisualize
BU of 8g35 by Molmil
Crystal structure of F182L-CYP199A4 in complex with (S)-4-(2-hydroxy-3-oxobutan-2-yl)benzoic acid
分子名称: 4-[(2S)-2-hydroxy-3-oxobutan-2-yl]benzoic acid, CHLORIDE ION, Cytochrome P450, ...
著者Lee, J.H.Z, Bell, S.G, Bruning, J.B.
登録日2023-02-06
公開日2023-05-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.
J.Am.Chem.Soc., 145, 2023
3V8D
DownloadVisualize
BU of 3v8d by Molmil
Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
分子名称: (3beta,8alpha,9beta)-3-hydroxycholest-5-en-7-one, Cholesterol 7-alpha-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Strushkevich, N, Tempel, W, MacKenzie, F, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Usanov, S.A, Park, H, Structural Genomics Consortium (SGC)
登録日2011-12-22
公開日2013-01-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
To be Published
8FKB
DownloadVisualize
BU of 8fkb by Molmil
X-ray crystal structure of CYP124A1 from Mycobacterium Marinum bound to Farnesol
分子名称: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, Cytochrome P450 124A1, DI(HYDROXYETHYL)ETHER, ...
著者Ghith, A, Bruning, J.B, Bell, S.G.
登録日2022-12-21
公開日2023-03-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.
Arch.Biochem.Biophys., 737, 2023
8FLO
DownloadVisualize
BU of 8flo by Molmil
X-ray crystal structure of substrate free CYP124A1 from Mycobacterium Marinum
分子名称: Cytochrome P450 124A1, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Ghith, A, Bruning, J.B, Bell, S.G.
登録日2022-12-22
公開日2023-03-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.
Arch.Biochem.Biophys., 737, 2023
8FJO
DownloadVisualize
BU of 8fjo by Molmil
X-ray crystal structure of CYP124A1 from Mycobacterium Marinum in complex with farnesyl acetate
分子名称: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl acetate, AMMONIUM ION, Cytochrome P450 124A1, ...
著者Ghith, A, Bruning, J.B, Bell, S.G.
登録日2022-12-20
公開日2023-03-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献The catalytic activity and structure of the lipid metabolizing CYP124 cytochrome P450 enzyme from Mycobacterium marinum.
Arch.Biochem.Biophys., 737, 2023
3VTJ
DownloadVisualize
BU of 3vtj by Molmil
Cytochrome P450SP alpha (CYP152B1) mutant A245H
分子名称: Fatty acid alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
著者Fujishiro, T, Shoji, O, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2012-05-30
公開日2013-06-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献A substrate-binding-state mimic of H2O2-dependent cytochrome P450 produced by one-point mutagenesis and peroxygenation of non-native substrates
Catalysis Science And Technology, 6, 2016
3VM4
DownloadVisualize
BU of 3vm4 by Molmil
Cytochrome P450SP alpha (CYP152B1) in complex with (R)-ibuprophen
分子名称: (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, Fatty acid alpha-hydroxylase, ...
著者Fujishiro, T, Shoji, O, Nagano, S, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2011-12-08
公開日2012-05-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Chiral-substrate-assisted stereoselective epoxidation catalyzed by H2O2-dependent cytochrome P450SP alpha
Chem Asian J, 7, 2012
8F91
DownloadVisualize
BU of 8f91 by Molmil
OxyB, a cytochrome P450 involved in keratinimicin biosynthesis
分子名称: OxyB, PROTOPORPHYRIN IX CONTAINING FE
著者Ireland, K.A, Davis, K.M.
登録日2022-11-22
公開日2023-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB.
Acs Chem.Biol., 18, 2023
8EKT
DownloadVisualize
BU of 8ekt by Molmil
CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1)
分子名称: (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, PROTOPORPHYRIN IX CONTAINING FE, sterol 14a-demethylase
著者Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I.
登録日2022-09-21
公開日2023-08-02
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Identification of Potent and Selective Inhibitors of Acanthamoeba : Structural Insights into Sterol 14 alpha-Demethylase as a Key Drug Target.
J.Med.Chem., 67, 2024
8EOH
DownloadVisualize
BU of 8eoh by Molmil
crystal structure of human Cytochrome P450 8B1 in complex with a C12-Pyridine Containing Steroid
分子名称: 12-(pyridin-3-yl)-8alpha,10alpha,13alpha,14beta-androsta-4,11-diene-3,17-dione, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
著者Liu, J, Scott, E.E.
登録日2022-10-03
公開日2023-08-02
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
J.Biol.Chem., 299, 2023
8EWP
DownloadVisualize
BU of 8ewp by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)
著者Sevrioukova, I.F.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8EWQ
DownloadVisualize
BU of 8ewq by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]benzamide}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+)
著者Sevrioukova, I.F.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8EWE
DownloadVisualize
BU of 8ewe by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {tert-butyl [1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]carbamate}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium
著者Sevrioukova, I.F.
登録日2022-10-22
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8EXB
DownloadVisualize
BU of 8exb by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-3-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)
著者Sevrioukova, I.F.
登録日2022-10-25
公開日2023-02-01
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8EWS
DownloadVisualize
BU of 8ews by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[2-(quinolin-2-yl-kappaN)-1-benzothiophen-3-yl-kappaC~3~]iridium(1+)
著者Sevrioukova, I.F.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8EWR
DownloadVisualize
BU of 8ewr by Molmil
Crystal structure of CYP3A4 bound to an inhibitor
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {tert-butyl [1-{[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]amino}-1-oxo-3-(pyridin-4-yl)propan-2-yl]carbamate}bis[2-(quinolin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+)
著者Sevrioukova, I.F.
登録日2022-10-24
公開日2023-02-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4.
Inorg.Chem., 62, 2023
8FIE
DownloadVisualize
BU of 8fie by Molmil
Crystal Structure of Erwinia tracheiphila CYP114 mutant - A261D
分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Stewart Jr, C.E, Alexander, L.E, Nagel, R.
登録日2022-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
8FIC
DownloadVisualize
BU of 8fic by Molmil
Crystal Structure of Erwinia tracheiphila CYP114 in complex with ent-kaurenoic acid (Crystal Form 1)
分子名称: (8alpha,9beta,10alpha,13alpha)-kaur-16-en-18-oic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Stewart Jr, C.E, Nagel, R.
登録日2022-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.
Proc.Natl.Acad.Sci.USA, 120, 2023
3TZO
DownloadVisualize
BU of 3tzo by Molmil
The role of I87 of CYP158A2 in oxidative coupling reaction
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450, SPERMINE
著者Zhao, B, Waterman, M.R.
登録日2011-09-27
公開日2012-01-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献The role of Ile87 of CYP158A2 in oxidative coupling reaction.
Arch.Biochem.Biophys., 518, 2012
3UA1
DownloadVisualize
BU of 3ua1 by Molmil
Crystal structure of the cytochrome P4503A4-bromoergocryptine complex
分子名称: Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, bromoergocryptine
著者Sevrioukova, I.F, Poulos, T.L.
登録日2011-10-20
公開日2011-12-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand.
J.Biol.Chem., 287, 2012
3UAS
DownloadVisualize
BU of 3uas by Molmil
Cytochrome P450 2B4 covalently bound to the mechanism-based inactivator 9-ethynylphenanthrene
分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Gay, S.C, Zhang, H, Shah, M.B, Stout, C.D, Halpert, J.R, Hollenberg, P.F.
登録日2011-10-21
公開日2013-01-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.939 Å)
主引用文献Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis.
Biochemistry, 52, 2013

221716

件を2024-06-26に公開中

PDB statisticsPDBj update infoContact PDBjnumon