3NWD
| Glycoprotein B from Herpes simplex virus type 1, Y179S mutant, low-pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Stampfer, S.D, Lou, H, Cohen, G.H, Eisenberg, R.J, Heldwein, E.E. | 登録日 | 2010-07-09 | 公開日 | 2010-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8803 Å) | 主引用文献 | Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1. J.Virol., 84, 2010
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1FY1
| [R23S,F25E]HBP, A MUTANT OF HUMAN HEPARIN BINDING PROTEIN (CAP37) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ETHANOL, ... | 著者 | Kastrup, J.S, Linde, V, Pedersen, A.K, Stoffer, B, Iversen, L.F, Larsen, I.K, Rasmussen, P.B, Flodgaard, H.J, Bjorn, S.E. | 登録日 | 2000-09-28 | 公開日 | 2001-09-28 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding. Proteins, 42, 2001
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8BFN
| E. coli Wadjet JetABC dimer of dimers | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | 著者 | Roisne-Hamelin, F, Beckert, B, Myasnikov, A, Li, Y, Gruber, S. | 登録日 | 2022-10-26 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage. Mol.Cell, 82, 2022
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1FY3
| [G175Q]HBP, A mutant of human heparin binding protein (CAP37) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Kastrup, J.S, Linde, V, Pedersen, A.K, Stoffer, B, Iversen, L.F, Larsen, I.K, Rasmussen, P.B, Flodgaard, H.J, Bjorn, S.E. | 登録日 | 2000-09-28 | 公開日 | 2001-09-28 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Two mutants of human heparin binding protein (CAP37): toward the understanding of the nature of lipid A/LPS and BPTI binding. Proteins, 42, 2001
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8BTZ
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4QP0
| Crystal Structure Analysis of the Endo-1,4-beta-mannanase from Rhizomucor miehei | 分子名称: | Endo-beta-mannanase, SULFATE ION | 著者 | Zheng, Q.J, Peng, Z, Liu, Y, Yan, Q.J, Chen, Z.Z, Qin, Z. | 登録日 | 2014-06-22 | 公開日 | 2014-11-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insights into the substrate specificity and transglycosylation activity of a fungal glycoside hydrolase family 5 beta-mannosidase. Acta Crystallogr.,Sect.D, 70, 2014
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3MVD
| Crystal structure of the chromatin factor RCC1 in complex with the nucleosome core particle | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Makde, R.D, England, J.R, Yennawar, H.P, Tan, S. | 登録日 | 2010-05-04 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature, 467, 2010
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3MZD
| Structure of penicillin-binding protein 5 from E. coli: cloxacillin acyl-enzyme complex | 分子名称: | (2R,4S)-2-[(1S)-1-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolid ine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase dacA, GLYCEROL | 著者 | Nicola, G, Tomberg, J, Pratt, R.F, Nicholas, R.A, Davies, C. | 登録日 | 2010-05-12 | 公開日 | 2011-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity Biochemistry, 49, 2010
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3MZE
| Structure of penicillin-binding protein 5 from E.coli: cefoxitin acyl-enzyme complex | 分子名称: | (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase dacA, GLYCEROL | 著者 | Nicola, G, Tomberg, J, Pratt, R.F, Nicholas, R.A, Davies, C. | 登録日 | 2010-05-12 | 公開日 | 2011-03-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity Biochemistry, 49, 2010
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6SRX
| Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0021158 | 分子名称: | ACETATE ION, CHLORIDE ION, Fab C0021158 heavy chain (IgG1), ... | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | 登録日 | 2019-09-06 | 公開日 | 2020-06-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action. Mabs, 12
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5NPN
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5FTN
| Cryo-EM structure of human p97 bound to ATPgS (Conformation III) | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | 登録日 | 2016-01-14 | 公開日 | 2016-01-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
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8CIC
| Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with clinical candidate Etrumadenant | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ... | 著者 | Cheng, R.K.Y, Markovic-Mueller, S, Hennig, M. | 登録日 | 2023-02-09 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem, 6, 2023
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6TVJ
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6T8B
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8CDG
| Crystal structure of human IL-17A cytokine in complex with macrocycle | 分子名称: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | 著者 | Schulze, M.-S. | 登録日 | 2023-01-30 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. Chem Sci, 14, 2023
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3ZTS
| Hexagonal form P6122 of the Aquifex aeolicus nucleoside diphosphate kinase (FINAL STAGE OF RADIATION DAMAGE) | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE | 著者 | Boissier, F, Georgescauld, F, Moynie, L, Dupuy, J.-W, Sarger, C, Podar, M, Lascu, I, Giraud, M.-F, Dautant, A. | 登録日 | 2011-07-12 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An Inter-Subunit Disulphide Bridge Stabilizes the Tetrameric Nucleoside Diphosphate Kinase of Aquifex Aeolicus Proteins, 80, 2012
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3ZTR
| Hexagonal form P6122 of the Aquifex aeolicus nucleoside diphosphate kinase (FIRST STAGE OF RADIATION DAMAGE) | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE | 著者 | Boissier, F, Georgescauld, F, Moynie, L, Dupuy, J.-W, Sarger, C, Podar, M, Lascu, I, Giraud, M.-F, Dautant, A. | 登録日 | 2011-07-12 | 公開日 | 2012-03-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An Inter-Subunit Disulphide Bridge Stabilizes the Tetrameric Nucleoside Diphosphate Kinase of Aquifex Aeolicus Proteins, 80, 2012
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5AP1
| Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 分子名称: | 6-{[3-(cyanomethoxy)-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-2-(cyclohexylamino)pyridine-3-carbonitrile, DUAL SPECIFICITY PROTEIN KINASE TTK, GLYCEROL, ... | 著者 | Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. | 登録日 | 2015-09-14 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
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5AP0
| Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. | 分子名称: | 1,2-ETHANEDIOL, 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE, DIMETHYL SULFOXIDE, ... | 著者 | Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.J, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R.L.M, Linardopoulos, S. | 登録日 | 2015-09-14 | 公開日 | 2015-09-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015
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3NWA
| Glycoprotein B from Herpes simplex virus type 1, W174R mutant, low-pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, MESO-ERYTHRITOL | 著者 | Stampfer, S.D, Lou, H, Cohen, G.H, Eisenberg, R.J, Heldwein, E.E. | 登録日 | 2010-07-09 | 公開日 | 2010-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2629 Å) | 主引用文献 | Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1. J.Virol., 84, 2010
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5M8H
| ATP phosphoribosyltransferase (HisZG ATPPRT) from Psychrobacter arcticus | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, ... | 著者 | Alphey, M.S, Ge, Y, Naismith, J.H, da Silva, R.G. | 登録日 | 2016-10-28 | 公開日 | 2017-09-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase. Biochemistry, 56, 2017
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5FTM
| Cryo-EM structure of human p97 bound to ATPgS (Conformation II) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Banerjee, S, Bartesaghi, A, Merk, A, Rao, P, Bulfer, S.L, Yan, Y, Green, N, Mroczkowski, B, Neitz, R.J, Wipf, P, Falconieri, V, Deshaies, R.J, Milne, J.L.S, Huryn, D, Arkin, M, Subramaniam, S. | 登録日 | 2016-01-14 | 公開日 | 2016-01-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition Science, 351, 2016
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5GSS
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8U3B
| Cryo-EM structure of E. coli NarL-transcription activation complex at 3.2A | 分子名称: | DNA (69-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Liu, B, Kompaniiets, D, Wang, D. | 登録日 | 2023-09-07 | 公開日 | 2024-01-17 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural basis for transcription activation by the nitrate-responsive regulator NarL. Nucleic Acids Res., 52, 2024
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