PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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8BUP	Structure of DDB1 bound to DS30-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[3-(3-methylphenyl)propylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUB	Structure of DDB1 bound to dCeMM4-engaged CDK12-cyclin K 分子名称: CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUL	Structure of DDB1 bound to DS11-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(3-phenylpropylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU3	Structure of DDB1 bound to DS19-engaged CDK12-cyclin K 分子名称: 1,2-ETHANEDIOL, 2-morpholin-4-yl-9-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]purin-6-amine, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUQ	Structure of DDB1 bound to DS43-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[1-(3-chlorophenyl)pyrazol-3-yl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUC	Structure of DDB1 bound to dCeMM3-engaged CDK12-cyclin K 分子名称: 2-(1~{H}-benzimidazol-2-ylsulfanyl)-~{N}-(5-chloranylpyridin-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.85 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU5	Structure of DDB1 bound to SR-4835-engaged CDK12-cyclin K 分子名称: CITRIC ACID, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.134 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUT	Structure of DDB1 bound to DS61-engaged CDK12-cyclin K 分子名称: 2-[[6-[[4-(2-hydroxyethyloxy)phenyl]methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUS	Structure of DDB1 bound to DS59-engaged CDK12-cyclin K 分子名称: 1,3-dimethyl-5-[[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]methyl]pyrazole-4-sulfonamide, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.26 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUH	Structure of DDB1 bound to WX3-engaged CDK12-cyclin K 分子名称: 6-[[[2-[[(2~{R})-1-oxidanylbutan-2-yl]amino]-9-propan-2-yl-purin-6-yl]amino]methyl]-3-pyridin-2-yl-1~{H}-pyridin-2-one, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.79 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUD	Structure of DDB1 bound to Z7-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUE	Structure of DDB1 bound to Z11-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUG	Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K 分子名称: 2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.53 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
7MKX	Crystal Structure Analysis of human CDK2 and CCNA2 complex 分子名称: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2021-04-27 公開日 2022-11-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Crystal Structure Analysis of human CDK2 and CCNA2 complex To Be Published
7NFW	Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide 分子名称: 14-3-3 protein sigma, Estrogen receptor 著者 Roversi, P, Falcicchio, M, Doveston, R. 登録日 2021-02-08 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification. Chem Sci, 12, 2021
4HC4	Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Protein arginine N-methyltransferase 6, ... 著者 Dong, A, Zeng, H, He, H, El Bakkouri, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-09-28 公開日 2012-10-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural basis of arginine asymmetrical dimethylation by PRMT6. Biochem. J., 473, 2016
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs 分子名称: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-09-18 公開日 2020-11-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
7NIZ	Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide and ligands Fusicoccin-A and WR-1065 分子名称: 14-3-3 protein sigma, Estrogen receptor, FUSICOCCIN, ... 著者 Roversi, P, Falcicchio, M, Doveston, R. 登録日 2021-02-14 公開日 2021-12-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification. Chem Sci, 12, 2021
4EK4	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor 分子名称: 4-bromo-N-(5-methyl-1H-pyrazol-3-yl)benzamide, Cyclin-dependent kinase 2, SODIUM ION 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-04-09 公開日 2013-05-01 最終更新日 2013-05-08 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of the cdk2 in complex with aminopyrazole inhibitor To be Published
8BX1	Oct4/Sox2 protein:DNA complex 分子名称: HOXB1_f, HOXB1_r, POU domain, ... 著者 Chojnowski, G, Wilmanns, M, Round, E. 登録日 2022-12-07 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of Oct4-Soc2-HoxB1 complex To Be Published
8BX2	Oct4/Sox2 protein:DNA complex 分子名称: POU domain, class 5, transcription factor 1, ... 著者 Chojnowski, G, Wilmanns, M, Round, E. 登録日 2022-12-07 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Crystal structure of Oct4-Soc2-UTF1 complex To Be Published
7NND	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09 分子名称: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-02-24 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
4FKP	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: 3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE, Cyclin-dependent kinase 2, SODIUM ION 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
7NMX	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12 分子名称: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CALCIUM ION, ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-02-23 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPG	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 22 分子名称: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-02-26 公開日 2022-01-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022

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