PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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4HCP	crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8 分子名称: GLYCEROL, NEDD8, Putative ATP/GTP binding protein, ... 著者 Yao, Q, Shao, F. 登録日 2012-10-01 公開日 2012-11-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis. Proc.Natl.Acad.Sci.USA, 109, 2012
4FKQ	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: 4-[(2Z)-2-(7-oxidanylidene-3,6-dihydropyrrolo[3,2-e]benzotriazol-8-ylidene)hydrazinyl]benzenesulfonamide, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
7ZJ3	Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate 分子名称: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K. 登録日 2022-04-08 公開日 2022-11-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity. Nat Commun, 13, 2022
4FKI	Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor 分子名称: Cyclin-dependent kinase 2, N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(trifluoromethoxy)phenyl]acetamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor To be Published
4FKT	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: Cyclin-dependent kinase 2, N-[2-(dimethylamino)ethyl]-4-{[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FKG	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor 分子名称: 4-[(5-cyclopropyl-1H-pyrazol-3-yl)carbamoyl]benzoic acid, Cyclin-dependent kinase 2 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Crystal structure of the cdk2 in complex with aminopyrazole inhibitor To be Published
4FKS	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: Cyclin-dependent kinase 2, N-[(4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}phenyl)sulfonyl]acetamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FKU	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
7ZRV	cryo-EM structure of omicron spike in complex with de novo designed binder, full map 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, ... 著者 Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. 登録日 2022-05-05 公開日 2023-03-08 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
4GUL	Study on structure and function relationships in human ferric Pirin 分子名称: FE (III) ION, Pirin 著者 Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. 登録日 2012-08-29 公開日 2013-05-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Pirin is an iron-dependent redox regulator of NF-kappa B. Proc.Natl.Acad.Sci.USA, 110, 2013
8BUM	Structure of DDB1 bound to DS15-engaged CDK12-cyclin K 分子名称: (2R)-2-[[6-(5-naphthalen-1-ylpentylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-20 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU7	Structure of DDB1 bound to 21195-engaged CDK12-cyclin K 分子名称: 1,2-ETHANEDIOL, 1-[2,6-bis(chloranyl)phenyl]-6-[[4-(2-hydroxyethyloxy)phenyl]methyl]-3-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.245 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUN	Structure of DDB1 bound to DS16-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUA	Structure of DDB1 bound to 919278-engaged CDK12-cyclin K 分子名称: (2~{R})-~{N}-(1~{H}-benzimidazol-2-yl)-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanamide, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.193 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU2	Structure of DDB1 bound to DS18-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUR	Structure of DDB1 bound to DS50-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.64 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUI	Structure of DDB1 bound to DRF-053-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)amino]purin-2-yl]amino]butan-1-ol, 1,2-ETHANEDIOL, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUF	Structure of DDB1 bound to Z12-engaged CDK12-cyclin K 分子名称: 2-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylmethyl)-6,7-dimethoxy-3~{H}-quinazolin-4-one, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU1	Structure of DDB1 bound to DS17-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUO	Structure of DDB1 bound to DS24-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[(3-fluoranyl-4-pyridin-2-yl-phenyl)methylamino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.58 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU4	Structure of DDB1 bound to DS22-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methylamino]-9-(1-methylpyrazol-4-yl)purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU6	Structure of DDB1 bound to DS55-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUJ	Structure of DDB1 bound to DS06-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(octylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, Cyclin-K, Cyclin-dependent kinase 12, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.62 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BUK	Structure of DDB1 bound to DS08-engaged CDK12-cyclin K 分子名称: (2~{R})-2-[[6-(naphthalen-2-ylmethylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol, CITRIC ACID, Cyclin-K, ... 著者 Kozicka, Z, Kempf, G, Petzold, G, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-01-03 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024
8BU9	Structure of DDB1 bound to roscovitine-engaged CDK12-cyclin K 分子名称: Cyclin-K, Cyclin-dependent kinase 12, DNA damage-binding protein 1, ... 著者 Kozicka, Z, Kempf, G, Focht, V, Thoma, N.H. 登録日 2022-11-30 公開日 2023-09-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.51 Å) 主引用文献 Design principles for cyclin K molecular glue degraders. Nat.Chem.Biol., 20, 2024

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