PDB: 1980 件ウェブページステータス検索Chemie searchBIRD

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6HLN	Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of enterovirus-D68 分子名称: Genome polyprotein, Golgi resident protein GCP60 著者 Klima, M, Boura, E. 登録日 2018-09-11 公開日 2019-07-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites. Plos Pathog., 15, 2019
6HLS	Yeast apo RNA polymerase I* 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Weis, F, Muller, C.W. 登録日 2018-09-11 公開日 2019-04-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
6HKO	Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Tafur, L, Sadian, Y, Weis, F, Muller, C.W. 登録日 2018-09-07 公開日 2019-04-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
6M99	In situ structure of transcriptional enzyme complex and asymmetric inner capsid protein of aquareovirus at primed state 分子名称: PHOSPHATE ION, Putative core protein NTPase/VP5, VP2, ... 著者 Ding, K, Zhou, Z.H. 登録日 2018-08-23 公開日 2018-09-05 最終更新日 2019-11-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In SituStructures of the Polymerase Complex and RNA Genome Show How Aquareovirus Transcription Machineries Respond to Uncoating. J. Virol., 92, 2018
5QJ1	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide 分子名称: 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, RNA-dependent RNA polymerase, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
5QJ0	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide 分子名称: 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, NONAETHYLENE GLYCOL, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
6EB9	Crystal Structure of the Nipah Virus Phosphoprotein Multimerization Domain Delta 542-544 分子名称: Phosphoprotein 著者 Bruhn, J.F, Saphire, E.O. 登録日 2018-08-06 公開日 2019-03-13 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function. Structure, 27, 2019
6EB8	Crystal Structure of the Nipah Virus Phosphoprotein Multimerization Domain G519N 分子名称: Phosphoprotein 著者 Bruhn, J.F, Saphire, E.O. 登録日 2018-08-06 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function. Structure, 27, 2019
6H9R	Dengue-RdRp3-inhibitor complex soaking 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-08-05 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6AE6	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 2) 分子名称: ACETATE ION, RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.856 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE4	Crystals structure of Classical swine fever virus NS5B (residues 1-694, Y471A mutant) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE7	Crystals structure of Classical swine fever virus NS5B (residues 1-672, E472A mutant) 分子名称: ACETATE ION, RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6AE5	Crystals structure of Classical swine fever virus NS5B (residues 1-672, Y471A mutant, form 1) 分子名称: RdRp catalytic 著者 Liu, W, Gong, P. 登録日 2018-08-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.754 Å) 主引用文献 A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6H80	Dengue-RdRp3-inhibitor complex co-crystallisation 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-07-31 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6H68	Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) with fully-ordered A49 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Sanz-Murillo, M, Xu, J, Gil-Carton, D, Wang, D, Fernandez-Tornero, C. 登録日 2018-07-26 公開日 2018-08-29 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6H67	Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Sanz-Murillo, M, Xu, J, Gil-Carton, D, Wang, D, Fernandez-Tornero, C. 登録日 2018-07-26 公開日 2018-08-29 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of RNA polymerase I stalling at UV light-induced DNA damage. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6H5Q	Cryo-EM structure of in vitro assembled Measles virus N into nucleocapsid-like particles (NCLPs) bound to polyA RNA hexamers. 分子名称: Nucleocapsid, RNA (5'-R(*AP*AP*AP*AP*AP*A)-3') 著者 Desfosses, A, Milles, S, Ringkjobing Jensen, M, Guseva, S, Colletier, J, Maurin, D, Schoehn, G, Gutsche, I, Ruigrok, R, Blackledge, M. 登録日 2018-07-25 公開日 2019-03-13 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication. Proc.Natl.Acad.Sci.USA, 116, 2019
6H5S	Cryo-EM map of in vitro assembled Measles virus N into nucleocapsid-like particles (NCLPs) bound to viral genomic 5-prime RNA hexamers. 分子名称: Nucleocapsid, RNA (5'-R(*AP*CP*CP*AP*GP*A)-3') 著者 Desfosses, A, Milles, S, Ringkjobing Jensen, M, Guseva, S, Colletier, J.P, Maurin, D, Schoehn, G, Gutsche, I, Ruigrok, R, Blackledge, M. 登録日 2018-07-25 公開日 2019-06-12 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication. Proc.Natl.Acad.Sci.USA, 116, 2019
6E6V	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Credille, C.V, Cohen, S.M. 登録日 2018-07-25 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019
6E6W	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(1H-tetrazol-5-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: 3-hydroxy-6-[2-methyl-4-(1H-tetrazol-5-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Dick, B.L, Morrison, C.N, Credille, C.V, Cohen, S.M. 登録日 2018-07-25 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019
6E6X	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 1-(4-(1H-tetrazol-5-yl)phenyl)-5-hydroxy-2-methylpyridin-4(1H)-one 分子名称: 1,2-ETHANEDIOL, 5-hydroxy-2-methyl-1-[4-(1H-tetrazol-5-yl)phenyl]pyridin-4(1H)-one, MANGANESE (II) ION, ... 著者 Dick, B.L, Morrison, C.N, Credille, C.V, Cohen, S.M. 登録日 2018-07-25 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019
6H58	Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... 著者 Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, D.N. 登録日 2018-07-24 公開日 2018-09-05 最終更新日 2018-10-24 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol, 3, 2018
6H4N	Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... 著者 Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, N.D. 登録日 2018-07-22 公開日 2018-09-05 最終更新日 2018-10-24 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol, 3, 2018
6E4C	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-(2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 3-hydroxy-6-[2-methyl-4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]-4-oxo-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, ... 著者 Morrison, C.N, Dick, B.L, Credille, C.V, Cohen, S.M. 登録日 2018-07-17 公開日 2019-07-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019
6E3M	The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 6-(3-carboxyphenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, ... 著者 Morrison, C.N, Dick, B.L, Credille, C.V, Cohen, S.M. 登録日 2018-07-14 公開日 2019-07-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62, 2019

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