6E6V

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Summary for 6E6V

Entry DOI	10.2210/pdb6e6v/pdb
Related	6E3M 6E3N 6E3O 6E3P 6E4C 6E4W 6E4X
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 3-hydroxy-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	pa endonuclease, inhibitor, influenza, h1n1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Influenza A virus
Total number of polymer chains	1
Total formula weight	22871.81
Authors	Dick, B.L.,Morrison, C.N.,Credille, C.V.,Cohen, S.M. (deposition date: 2018-07-25, release date: 2019-07-31, Last modification date: 2023-10-11)
Primary citation	Credille, C.V.,Morrison, C.N.,Stokes, R.W.,Dick, B.L.,Feng, Y.,Sun, J.,Chen, Y.,Cohen, S.M. SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease. J.Med.Chem., 62:9438-9449, 2019 Cited by PubMed: 31536340 DOI: 10.1021/acs.jmedchem.9b00747 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation