Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD)

Summary for 6H67

EMDB information0146
DescriptorDNA-directed RNA polymerase I subunit RPA190, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerases I and III subunit RPAC1, ... (19 entities in total)
Functional Keywordsrna polymerase i, uv-damage, stalling, cyclobutane pyrimidine dimers (cpd), transcription
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Total number of polymer chains17
Total molecular weight625814.71
Sanz-Murillo, M.,Xu, J.,Gil-Carton, D.,Wang, D.,Fernandez-Tornero, C. (deposition date: 2018-07-26, release date: 2018-08-29, Last modification date: 2018-09-12)
Primary citation
Sanz-Murillo, M.,Xu, J.,Belogurov, G.A.,Calvo, O.,Gil-Carton, D.,Moreno-Morcillo, M.,Wang, D.,Fernandez-Tornero, C.
Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.
Proc. Natl. Acad. Sci. U.S.A., 115:8972-8977, 2018
PubMed: 30127008 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1802626115
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone50.0%0.1%0.67MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures