4OG5
| Human menin with bound inhibitor MIV-5 | 分子名称: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | 登録日 | 2014-01-15 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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4ONN
| Crystal structure of human Mms2/Ubc13 - BAY 11-7082 | 分子名称: | 3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile, GLYCEROL, Ubiquitin-conjugating enzyme E2 N, ... | 著者 | Hodge, C.D, Edwards, R.A, Glover, J.N.M. | 登録日 | 2014-01-28 | 公開日 | 2015-05-06 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. Acs Chem.Biol., 10, 2015
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6GJT
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1L0L
| structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone | 分子名称: | Cytochrome B, Cytochrome c1, heme protein, ... | 著者 | Gao, X, Wen, X, Yu, C.A, Esser, L, Tsao, S, Quinn, B, Zhang, L, Yu, L, Xia, D. | 登録日 | 2002-02-11 | 公開日 | 2003-04-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Famoxadone: The Role of Aromatic-Aromatic Interaction in Inhibition Biochemistry, 41, 2003
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1FUQ
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4OG4
| Human menin with bound inhibitor MIV-3S | 分子名称: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | 登録日 | 2014-01-15 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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3EZK
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3F63
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1J96
| Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone | 分子名称: | 3alpha-hydroxysteroid dehydrogenase type 3, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Nahoum, V, Labrie, F, Lin, S.-X. | 登録日 | 2001-05-23 | 公開日 | 2002-05-23 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. J.Biol.Chem., 276, 2001
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1IEL
| Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Ceftazidime | 分子名称: | ACYLATED CEFTAZIDIME, PHOSPHATE ION, beta-lactamase | 著者 | Powers, R.A, Caselli, E, Focia, P.J, Prati, F, Shoichet, B.K. | 登録日 | 2001-04-10 | 公開日 | 2001-08-15 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry, 40, 2001
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2O48
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1QMQ
| Optical detection of cytochrome P450 by sensitizer-linked substrates | 分子名称: | ACETATE ION, CYTOCHROME P450, DELTA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C9-ADAMANTANE RUTHENIUM (II), ... | 著者 | Crane, B.R, Dmochowski, I.J, Gray, H.B. | 登録日 | 1999-10-05 | 公開日 | 2000-10-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Optical Detection of Cytochrome P450 by Sensitizer-Linked Substrates Proc.Natl.Acad.Sci.USA, 96, 1999
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1HIZ
| Xylanase T6 (Xt6) from Bacillus Stearothermophilus | 分子名称: | ENDO-1,4-BETA-XYLANASE, SULFATE ION, alpha-D-galactopyranose, ... | 著者 | Sainz, G, Tepplitsky, A, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | 登録日 | 2001-01-05 | 公開日 | 2002-01-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure Determination of the Extracellular Xylanase from Geobacillus Stearothermophilus by Selenomethionyl MAD Phasing Acta Crystallogr.,Sect.D, 60, 2004
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1RWL
| Extracellular domain of Mycobacterium tuberculosis PknD | 分子名称: | CADMIUM ION, Serine/threonine-protein kinase pknD | 著者 | Good, M.C, Greenstein, A.E, Young, T.A, Ng, H.L, Alber, T, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2003-12-16 | 公開日 | 2004-04-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Sensor Domain of the Mycobacterium tuberculosis Receptor Ser/Thr Protein Kinase, PknD, forms a Highly Symmetric beta Propeller. J.Mol.Biol., 339, 2004
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2PIY
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2PIZ
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2V9W
| Complex structure of Sulfolobus solfataricus DPO4 and DNA duplex containing a hydrophobic thymine isostere 2,4-difluorotoluene nucleotide in the template strand | 分子名称: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *CP*TP*G)-3', 5'-D(*TP*TP*CP*AP*GP*DFTP*AP*GP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Pallan, P.S, Egli, M. | 登録日 | 2007-08-27 | 公開日 | 2007-10-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene. J.Biol.Chem., 282, 2007
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3G7J
| Crystal Structure of a Genetically Modified Delta Class GST (adGSTD4-4) from Anopheles dirus, Y119E, in Complex with S-Hexyl Glutathione | 分子名称: | Glutathione transferase GST1-4, S-HEXYLGLUTATHIONE | 著者 | Wongsantichon, J, Robinson, R.C, Ketterman, A.J. | 登録日 | 2009-02-10 | 公開日 | 2010-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural contributions of delta class glutathione transferase active-site residues to catalysis Biochem.J., 428, 2010
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1PBE
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3IXX
| The pseudo-atomic structure of West Nile immature virus in complex with Fab fragments of the anti-fusion loop antibody E53 | 分子名称: | E53 Fab Fragment (chain H), E53 Fab Fragment (chain L), Envelope protein E, ... | 著者 | Cherrier, M.V, Kaufmann, B, Nybakken, G.E, Lok, S.M, Warren, J.T, Nelson, C.A, Kostyuchenko, V.A, Holdaway, H.A, Chipman, P.R, Kuhn, R.J, Diamond, M.S, Rossmann, M.G, Fremont, D.H. | 登録日 | 2009-02-26 | 公開日 | 2009-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody Embo J., 28, 2009
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3IYA
| Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH | 分子名称: | Envelope protein, prM protein | 著者 | Yu, I, Holdaway, H.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J. | 登録日 | 2009-06-01 | 公開日 | 2010-04-14 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (22 Å) | 主引用文献 | Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. J.Virol., 83, 2009
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2VA3
| Complex structure of Sulfolobus solfataricus DPO4 and DNA duplex containing a hydrophobic thymine isostere 2,4-difluorotoluene nucleotide in the template strand | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *CP*TP*A)-3', 5'-D(*TP*TP*CP*AP*DFTP*TP*AP*GP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... | 著者 | Irimia, A, Pallan, P.S, Egli, M. | 登録日 | 2007-08-28 | 公開日 | 2007-10-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structure and Activity of Y-Class DNA Polymerase Dpo4 from Sulfolobus Solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene. J.Biol.Chem., 282, 2007
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3J0B
| cryo-EM reconstruction of West Nile virus | 分子名称: | envelope glycoprotein E | 著者 | Zhang, W, Kaufmann, B, Chipman, P.R, Kuhn, R.J, Rossmann, M.G. | 登録日 | 2011-06-15 | 公開日 | 2012-12-19 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (10.3 Å) | 主引用文献 | Membrane curvature in flaviviruses. J.Struct.Biol., 183, 2013
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1T7K
| Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea | 分子名称: | 3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE, Pol polyprotein [Contains: Protease (Retropepsin)] | 著者 | Huang, P.P, Randolph, J.T, Klein, L.L, Vasavanonda, S, Dekhtyar, T, Stoll, V.S, Kempf, D.J. | 登録日 | 2004-05-10 | 公開日 | 2004-10-05 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Synthesis and Antiviral Activity of P1' Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors Bioorg.Med.Chem.Lett., 14, 2004
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3J0O
| Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2 | 分子名称: | 40S ribosomal RNA fragment, 60S ribosomal RNA fragment, Ribosomal protein L10a, ... | 著者 | Budkevich, T, Giesebrecht, J, Altman, R, Munro, J, Mielke, T, Nierhaus, K, Blanchard, S, Spahn, C.M. | 登録日 | 2011-10-05 | 公開日 | 2011-11-16 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Structure and dynamics of the Mammalian ribosomal pretranslocation complex. Mol.Cell, 44, 2011
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