5DIT
 
 | | The Fk1 domain of FKBP51 in complex with the new synthetic ligand (1R)-3-(3,4-dimethoxyphenyl)-1-f3-[2-(morpholin-4-yl)ethoxy]phenylgpropyl(2S)-1-[(2S,3R)-2-cyclohexyl-3-hydroxybutanoyl]piperidine-2-carboxylate | | 分子名称: | (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S,3R)-2-cyclohexyl-3-hydroxybutanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Feng, X, Sippel, C, Bracher, A, Hausch, F. | | 登録日 | 2015-09-01 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands.
J.Med.Chem., 58, 2015
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7JMG
 | | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 22 - State 2 (S2) | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | | 登録日 | 2020-07-31 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots.
Nat Commun, 11, 2020
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7JMF
 | | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 42 - State 6 (S6) | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | | 登録日 | 2020-07-31 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots.
Nat Commun, 11, 2020
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7JMI
 | | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 29 - State 3 (S3) | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | | 登録日 | 2020-07-31 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots.
Nat Commun, 11, 2020
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7JMJ
 | | Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots - Frame 37 - State 5 (S5) | | 分子名称: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION, ... | | 著者 | Dashti, A, des Georges, A, Frank, J, Ourmazd, A. | | 登録日 | 2020-07-31 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Retrieving functional pathways of biomolecules from single-particle snapshots.
Nat Commun, 11, 2020
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5BXJ
 | | Complex of the Fk1 domain mutant A19T of FKBP51 with 4-Nitrophenol | | 分子名称: | P-NITROPHENOL, Peptidyl-prolyl cis-trans isomerase FKBP5 | | 著者 | Wu, D, Tao, X, Chen, Z, Han, J, Jia, W, Li, X, Wang, Z, He, Y.X. | | 登録日 | 2015-06-09 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells
J. Hazard. Mater., 307, 2016
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1U79
 | | Crystal structure of AtFKBP13 | | 分子名称: | FKBP-type peptidyl-prolyl cis-trans isomerase 3 | | 著者 | Gopalan, G, Swaminathan, K. | | 登録日 | 2004-08-03 | | 公開日 | 2004-09-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen
Proc.Natl.Acad.Sci.Usa, 101, 2004
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4IPX
 | | Analyzing the visible conformational substates of the FK506 binding protein FKBP12 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A | | 著者 | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | | 登録日 | 2013-01-10 | | 公開日 | 2013-06-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Analysing the visible conformational substates of the FK506-binding protein FKBP12.
Biochem.J., 453, 2013
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4IQ2
 | | P21 crystal form of FKBP12.6 | | 分子名称: | MALONIC ACID, Peptidyl-prolyl cis-trans isomerase FKBP1B | | 著者 | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | | 登録日 | 2013-01-10 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
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4IQC
 | | P3121 crystal form of FKBP12.6 | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B | | 著者 | Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G. | | 登録日 | 2013-01-11 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | | 主引用文献 | Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
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1FKJ
 | | ATOMIC STRUCTURE OF FKBP12-FK506, AN IMMUNOPHILIN IMMUNOSUPPRESSANT COMPLEX | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN | | 著者 | Wilson, K.P, Sintchak, M.D, Thomson, J.A, Navia, M.A. | | 登録日 | 1995-08-18 | | 公開日 | 1995-12-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.
Acta Crystallogr.,Sect.D, 51, 1995
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1FKI
 | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | 分子名称: | (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE, FK506 BINDING PROTEIN | | 著者 | Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J. | | 登録日 | 1993-08-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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1FKF
 | | ATOMIC STRUCTURE OF FKBP-FK506, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN | | 著者 | Vanduyne, G.D, Standaert, R.F, Karplus, P.A, Schreiber, S.L, Clardy, J. | | 登録日 | 1991-05-07 | | 公開日 | 1991-07-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.
Science, 252, 1991
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1FKT
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | 分子名称: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | 著者 | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | 登録日 | 1992-03-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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1FKB
 | | ATOMIC STRUCTURE OF THE RAPAMYCIN HUMAN IMMUNOPHILIN FKBP-12 COMPLEX | | 分子名称: | FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | 著者 | Van Duyne, G.D, Standaert, R.F, Schreiber, S.L, Clardy, J.C. | | 登録日 | 1992-07-02 | | 公開日 | 1993-10-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex
J.Am.Chem.Soc., 113, 1991
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1FKR
 | | SOLUTION STRUCTURE OF FKBP, A ROTAMASE ENZYME AND RECEPTOR FOR FK506 AND RAPAMYCIN | | 分子名称: | FK506 AND RAPAMYCIN-BINDING PROTEIN | | 著者 | Michnick, S.W, Rosen, M.K, Wandless, T.J, Karplus, M, Schreiber, S.L. | | 登録日 | 1992-03-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.
Science, 252, 1991
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1FKD
 | | FK-506 BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818 | | 分子名称: | 18-HYDROXYASCOMYCIN, FK506 BINDING PROTEIN | | 著者 | Becker, J.W, Rotonda, J, Mckeever, B.M. | | 登録日 | 1992-12-02 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
J.Biol.Chem., 268, 1993
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2DG9
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2DG4
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2D9F
 | | Solution structure of RUH-047, an FKBP domain from human cDNA | | 分子名称: | FK506-binding protein 8 variant | | 著者 | Ruhul Momen, A.Z.M, Hirota, H, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-12-09 | | 公開日 | 2006-06-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of RUH-047, an FKBP domain from human cDNA
To be Published
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2DG3
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2FKE
 | | FK-506-BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818 | | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN | | 著者 | Becker, J.W, Mckeever, B.M, Rotonda, J. | | 登録日 | 1993-01-27 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.
J.Biol.Chem., 268, 1993
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2F2D
 | | Solution structure of the FK506-binding domain of human FKBP38 | | 分子名称: | 38 kDa FK-506 binding protein homolog, FKBP38 | | 著者 | Maestre-Martinez, M, Edlich, F, Jarczowski, F, Weiwad, M, Fischer, G, Luecke, C. | | 登録日 | 2005-11-16 | | 公開日 | 2006-05-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the FK506-Binding Domain of Human FKBP38
J.BIOMOL.NMR, 34, 2006
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2F4E
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1FKG
 | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | 分子名称: | 1,3-DIPHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE, FK506 BINDING PROTEIN | | 著者 | Holt, D.A, Luengo, J.I, Yamashita, D.S, Oh, H.-J, Konialian, A.L, Yen, H.-K, Rozamus, L.W, Brandt, M, Bossard, M.J, Levy, M.A, Eggleston, D.S, Stout, T.J, Liang, J, Schultz, L.W, Clardy, J. | | 登録日 | 1993-08-05 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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