PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX0	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074388) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWX	Fragment-linked stabilizer for 14-3-3 and ERa (1075298) 分子名称: 14-3-3 protein sigma, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ERalpha peptide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) 分子名称: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWH	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BWE	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Visser, E.J, Pennings, M.A.M, Ottmann, C. 登録日 2022-12-06 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BWJ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074386) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-2-[4-(trifluoromethyl)phenoxy]propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-06 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BTQ	Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, MAGNESIUM ION, ... 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-11-29 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
8BM5	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7 分子名称: 14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-11-10 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8HEW	Potato 14-3-3 St14f 分子名称: 14-3-3 protein, StFDL1 peptide 著者 Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. 登録日 2022-11-08 公開日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J., 112, 2022
8BJG	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8 分子名称: 14-3-3 protein sigma, 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-11-04 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BJN	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6 分子名称: 14-3-3 protein sigma, 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-11-04 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BI7	Binary structure of 14-3-3s and PKR phosphopeptide 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide 著者 Somsen, B.A, Ottmann, C. 登録日 2022-11-01 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8BFC	Binary structure of 14-3-3s and RND3 phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-10-24 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8EQ8	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y130 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8EQH	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
8B5P	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 10 分子名称: 14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-09-23 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B4Q	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5 分子名称: 14-3-3 protein sigma, 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-09-20 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B39	Small molecular stabilizer for ERalpha and 14-3-3 (1080299) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[(2~{S},6~{R})-4-[(4-chlorophenyl)amino]-2,6-dimethyl-oxan-4-yl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-09-16 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8B2K	Ternary structure of 14-3-3s, RND3 phosphopeptide and dual-reactive compound 10 分子名称: 14-3-3 protein sigma, 3-bromanyl-5-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-09-14 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8B2I	Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 4 分子名称: 14-3-3 protein sigma, 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-09-14 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023
8AZE	Small molecule stabilizer for ERalpha and 14-3-3 (1075306) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-[(4-chlorophenyl)amino]cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, ERalpha peptide, ... 著者 Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M. 登録日 2022-09-06 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8AXU	Small molecule stabilizer for ERalpha and 14-3-3 (1075297) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[1-(4-chloranylphenoxy)cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... 著者 Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M. 登録日 2022-09-01 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8AXE	Small molecule stabilizer for ERalpha and 14-3-3 (1074210) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[2-[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]ethyl]ethanamide, Estrogen receptor, ... 著者 Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M. 登録日 2022-08-31 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
8AWG	small molecule stabilizer for ERalpha and 14-3-3 (1074202) 分子名称: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]piperidin-4-yl]methyl]ethanamide, Estrogen receptor, ... 著者 Konstantinidou, M, Visser, E.J, Vandenboorn, E.M.F, Sheng, C, Jaishankar, P, Overmans, M.J.A.M, Dutta, S, Neitz, J, Renslo, A, Ottmann, C, Brunsveld, L, Arkin, M. 登録日 2022-08-29 公開日 2023-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023

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