7NDC
| EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-159 Fab light chain, ... | 著者 | Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D. | 登録日 | 2021-01-30 | 公開日 | 2021-03-03 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 184, 2021
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7NDD
| EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-159 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-159 Fab heavy chain, ... | 著者 | Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D. | 登録日 | 2021-01-30 | 公開日 | 2021-03-03 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 184, 2021
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7OWJ
| Odinarchaeota Adenylate kinase (OdinAK) in complex with GTP | 分子名称: | Adenylate kinase, GUANOSINE-5'-TRIPHOSPHATE | 著者 | Aberg-Zingmark, E, Grundstrom, C, Verma, A, Wolf-Watz, M, Sauer, U.H, Sauer-Eriksson, A.E. | 登録日 | 2021-06-18 | 公開日 | 2022-09-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases. Sci Adv, 8, 2022
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4UEX
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4UHC
| Structural studies of a thermophilic esterase from Thermogutta terrifontis (Native) | 分子名称: | CHLORIDE ION, ESTERASE | 著者 | Sayer, C, Isupov, M.N, Bonch-Osmolovskaya, E, Littlechild, J.A. | 登録日 | 2015-03-24 | 公開日 | 2015-06-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Structural Studies of a Thermophilic Esterase from a New Planctomycetes Species, Thermogutta Terrifontis. FEBS J., 282, 2015
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4UMW
| CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN E2.PI STATE | 分子名称: | MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ZINC-TRANSPORTING ATPASE | 著者 | Wang, K.T, Sitsel, O, Meloni, G, Autzen, H.E, Andersson, M, Klymchuk, T, Nielsen, A.M, Rees, D.C, Nissen, P, Gourdon, P. | 登録日 | 2014-05-21 | 公開日 | 2014-08-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | 主引用文献 | Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases. Nature, 514, 2014
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4UID
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4UIC
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4UCR
| Fragment bound to H.influenza NAD dependent DNA ligase | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxy-2-methylquinoline-6-carboxamide, DNA LIGASE | 著者 | Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. | 登録日 | 2014-12-04 | 公開日 | 2015-10-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
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7NOS
| Crystal structure of Mycobacterium tuberculosis ArgF in complex with 4-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazole. | 分子名称: | 4-bromanyl-6-(trifluoromethyl)-1~{H}-benzimidazole, Ornithine carbamoyltransferase, PHOSPHATE ION | 著者 | Mendes, V, Gupta, P, Burgess, A, Sebastian-Perez, V, Cattermole, E, Meghir, C, Blundell, T.L. | 登録日 | 2021-02-25 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis Comput Struct Biotechnol J, 19, 2021
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4W8S
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8FB4
| Structure of an alternating AT 16-mer bound by diamidine DB1476: 5'-GCTGGATATATCCAGC-3 | 分子名称: | 4,4'-(1H-benzimidazole-2,6-diyl)di(benzene-1-carboximidamide), CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*GP*AP*TP*AP*TP*AP*TP*CP*CP*AP*GP*C)-3') | 著者 | Terrell, J.R, Ogbonna, E.N, Wilson, W.D. | 登録日 | 2022-11-29 | 公開日 | 2023-02-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. Acs Bio Med Chem Au, 3, 2023
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7NOV
| Crystal structure of Mycobacterium tuberculosis ArgF in complex with (4-methyl-3-nitrophenyl)boronic acid. | 分子名称: | (4-methyl-3-nitro-phenyl)-oxidanyl-oxidanylidene-boron, Ornithine carbamoyltransferase, PHOSPHATE ION | 著者 | Mendes, V, Gupta, P, Burgess, A, Sebastian-Perez, V, Cattermole, E, Meghir, C, Blundell, T.L. | 登録日 | 2021-02-26 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis Comput Struct Biotechnol J, 19, 2021
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4X64
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. | 登録日 | 2014-12-06 | 公開日 | 2015-11-18 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat.Struct.Mol.Biol., 23, 2016
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4V3N
| Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link | 分子名称: | PLEUROTOLYSIN A, PLEUROTOLYSIN B | 著者 | Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R. | 登録日 | 2014-10-20 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (14 Å) | 主引用文献 | Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin. Plos Biol., 13, 2015
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4UUL
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4V3A
| Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link | 分子名称: | PLEUROTOLYSIN A, PLEUROTOLYSIN B | 著者 | Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R. | 登録日 | 2014-10-17 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin. Plos Biol., 13, 2015
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4V3M
| Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link | 分子名称: | PLEUROTOLYSIN A, PLEUROTOLYSIN B | 著者 | Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R. | 登録日 | 2014-10-20 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin. Plos Biol., 13, 2015
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7Q1B
| Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat | 分子名称: | 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, GLYCEROL, Histone deacetylase DAC2, ... | 著者 | Marek, M, Ramos-Morales, E, Romier, C. | 登録日 | 2021-10-18 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37, 2021
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4X65
| Crystal Structure of 30S ribosomal subunit from Thermus thermophilus | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Demirci, H, Chen, J, Choi, J, Soltis, M, Puglisi, J.D. | 登録日 | 2014-12-06 | 公開日 | 2015-11-18 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (3.345 Å) | 主引用文献 | N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics. Nat.Struct.Mol.Biol., 23, 2016
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8FO6
| Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. | 分子名称: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | 登録日 | 2022-12-29 | 公開日 | 2023-05-03 | 実験手法 | X-RAY DIFFRACTION (2.553 Å) | 主引用文献 | ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
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4V3J
| Structural and functional characterization of a novel monotreme- specific protein from the milk of the platypus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MONOTREME LACTATING PROTEIN | 著者 | Kumar, A, Newman, J, Polekina, G, Adams, T.E, Sharp, J.A, Peat, T.S, Nicholas, K.R. | 登録日 | 2014-10-20 | 公開日 | 2016-01-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus. Acta Crystallogr F Struct Biol Commun, 74, 2018
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7Q0D
| Human carbonic anhydrase I in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Carbonic anhydrase 1, ... | 著者 | Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-10-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7PUU
| Crystal structure of carbonic anhydrase XII with methyl 4-chloro-2-cyclohexylsulfanyl-5-sulfamoylbenzoate | 分子名称: | 1,2-ETHANEDIOL, Carbonic anhydrase 12, ZINC ION, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-09-30 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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7Q0E
| Human Carbonic Anhydrase II in complex with Methyl 2-(benzenesulfonyl)-4-chloro-5-sulfamoylbenzoate | 分子名称: | BICINE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... | 著者 | Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2021-10-14 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX. Int J Mol Sci, 23, 2021
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