PDB: 46984 件ウェブページステータス検索Chemie searchBIRD

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5IOK	Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr 分子名称: (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14 著者 Andrews, F.H, Kuateladze, T.G. 登録日 2016-03-08 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 The Taf14 YEATS domain is a reader of histone crotonylation. Nat.Chem.Biol., 12, 2016
5DYP	Crystal structure of Asp251Gly/Gln307His mutant of cytochrome P450 BM3 分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE 著者 Di Nardo, G, Dell'Angelo, V, Gilardi, G. 登録日 2015-09-25 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. Arch.Biochem.Biophys., 602, 2016
5J8K	Architecture of supercomplex I-III2 分子名称: COMPLEX I 13KDA/NDUFS6, COMPLEX I 15KDA/NDUFS5, COMPLEX I 18KDA/NDUFS6, ... 著者 Letts, J.A, Fiedorczuk, K, Sazanov, L.A. 登録日 2016-04-08 公開日 2016-09-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 The architecture of respiratory supercomplexes. Nature, 537, 2016
5ES3	Co-crystal structure of LDH liganded with oxamate 分子名称: L-lactate dehydrogenase A chain, OXAMIC ACID 著者 Nowicki, M.W, Wear, M.A, McNae, I.W, Blackburn, E.A. 登録日 2015-11-16 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using AKTAxpressTM. Plos One, 10, 2015
5FIL	Bovine mitochondrial ATP synthase state 3b 分子名称: ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL, ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, ... 著者 Zhou, A, Rohou, A, Schep, D.G, Bason, J.V, Montgomery, M.G, Walker, J.E, Grigorieff, N, Rubinstein, J.L. 登録日 2015-09-28 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.1 Å) 主引用文献 Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM. Elife, 4, 2015
5FPV	Crystal structure of human JMJD2A in complex with compound KDOAM20A 分子名称: 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, ... 著者 Srikannathasan, V, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. 登録日 2015-12-03 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
5CSL	Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Acetyl-CoA carboxylase, COENZYME A 著者 Wei, J, Tong, L. 登録日 2015-07-23 公開日 2015-10-28 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 2015
5LXP	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H5 分子名称: Poly [ADP-ribose] polymerase 14, ~{N}'-(3-aminocarbonylphenyl)-~{N}-[[1-[(2~{R})-2-phenylpropyl]-1,2,3-triazol-4-yl]methyl]pentanediamide 著者 Karlberg, T, Thorsell, A.G, Schuler, H. 登録日 2016-09-22 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew. Chem. Int. Ed. Engl., 56, 2017
5LYH	Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10 分子名称: 3-[2-[4-[2-[[4-[(3-aminocarbonylphenyl)amino]-4-oxidanylidene-butanoyl]amino]ethyl]-1,2,3-triazol-1-yl]ethylsulfamoyl]benzoic acid, Poly [ADP-ribose] polymerase 14 著者 Karlberg, T, Thorsell, A.G, Schuler, H. 登録日 2016-09-28 公開日 2016-12-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew. Chem. Int. Ed. Engl., 56, 2017
7JMN	Tail module of Mediator complex 分子名称: MED15, Mediator of RNA polymerase II transcription subunit 14, Mediator of RNA polymerase II transcription subunit 16, ... 著者 Zhang, H.Q, Chen, D.C. 登録日 2020-08-02 公開日 2021-03-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Mediator structure and conformation change. Mol.Cell, 81, 2021
5ETI	Structure of dead kinase MAPK14 分子名称: Mitogen-activated protein kinase 14 著者 Pellegrini, E, Bowler, M.W. 登録日 2015-11-17 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381, 2023
5ETF	Structure of dead kinase MAPK14 with bound the KIM domain of MKK6 分子名称: Dual specificity mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase 14 著者 Pellegrini, E, Palencia, A, Braun, L, Kapp, U, Bougdour, A, Belrhali, H, Bowler, M.W, Hakimi, M. 登録日 2015-11-17 公開日 2016-10-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist. Structure, 25, 2017
5ETC	Structure of inactive MAPK14 with ordered Activation Loop 分子名称: Mitogen-activated protein kinase 14, SULFATE ION 著者 Kapp, U, Pellegrini, E, Bowler, M.W. 登録日 2015-11-17 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.422 Å) 主引用文献 Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381, 2023
1FQT	CRYSTAL STRUCTURE OF THE RIESKE-TYPE FERREDOXIN ASSOCIATED WITH BIPHENYL DIOXYGENASE 分子名称: FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, RIESKE-TYPE FERREDOXIN OF BIPHENYL DIOXYGENASE 著者 Colbert, C.L, Couture, M.M.-J, Eltis, L.D, Bolin, J.T. 登録日 2000-09-06 公開日 2001-01-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A cluster exposed: structure of the Rieske ferredoxin from biphenyl dioxygenase and the redox properties of Rieske Fe-S proteins. Structure Fold.Des., 8, 2000
7KEZ	Crystal structure of bH1 Fab variant (CDR H3 loop design 16_0325) in complex with VEGF 分子名称: CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, anti-VEGF-A Fab bH1 heavy chain, ... 著者 Shi, R, Manenda, M.S, Picard, M.-E. 登録日 2020-10-13 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF to be published
7KF0	Crystal structure of bH1 Fab variant (CDR H3 loop design 13_0346) in complex with VEGF 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Isoform L-VEGF206 of Vascular endothelial growth factor A, ... 著者 Shi, R, Picard, M.-E. 登録日 2020-10-13 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Crystal structure of bH1 Fab CDR H3 loop variants in apo form and in complex with VEGF to be published
5JLH	Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ... 著者 von der Ecken, J, Heissler, S.M, Pathan-Chhatbar, S, Manstein, D.J, Raunser, S. 登録日 2016-04-27 公開日 2016-06-15 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature, 534, 2016
5TCU	Methicillin sensitive Staphylococcus aureus 70S ribosome 分子名称: 16S RRNA, 23S RRNA, 30S ribosomal protein S10, ... 著者 Eyal, Z, Ahmed, T, Belousoff, N, Mishra, S, Matzov, D, Bashan, A, Zimmerman, E, Lithgow, T, Bhushan, S, Yonath, A. 登録日 2016-09-15 公開日 2017-05-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome. MBio, 8, 2017
1F20	CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION. 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, GLYCEROL, ... 著者 Zhang, J, Martasek, P, Masters, B.S, Kim, J.P. 登録日 2000-05-22 公開日 2001-10-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase. J.Biol.Chem., 276, 2001
1GGC	MAJOR ANTIGEN-INDUCED DOMAIN REARRANGEMENTS IN AN ANTIBODY 分子名称: IGG2A-KAPPA 50.1 FAB (HEAVY CHAIN), IGG2A-KAPPA 50.1 FAB (LIGHT CHAIN) 著者 Takimoto-Kamimura, M, Wilson, I.A. 登録日 1993-07-19 公開日 1993-10-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Major antigen-induced domain rearrangements in an antibody. Structure, 1, 1993
3NNW	Crystal structure of P38 alpha in complex with DP802 分子名称: 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide, Mitogen-activated protein kinase 14 著者 Abendroth, J. 登録日 2010-06-24 公開日 2010-09-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010
3NNX	Crystal structure of phosphorylated P38 alpha in complex with DP802 分子名称: 2-[3-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide, Mitogen-activated protein kinase 14 著者 Abendroth, J. 登録日 2010-06-24 公開日 2010-09-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region Bioorg.Med.Chem.Lett., 20, 2010
5Y5Y	V/A-type ATPase/synthase from Thermus thermophilus, peripheral domain, rotational state 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, V-type ATP synthase alpha chain, V-type ATP synthase beta chain, ... 著者 Nakanishi, A, Kishikawa, J, Tamakoshi, M, Mitsuoka, K, Yokoyama, K. 登録日 2017-08-10 公開日 2018-01-24 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Cryo EM structure of intact rotary H+-ATPase/synthase from Thermus thermophilus Nat Commun, 9, 2018
6SO1	Fragment N13569a in complex with MAP kinase p38-alpha 分子名称: 1-(1,3-benzodioxol-5-yl)-~{N}-[[(2~{R})-oxolan-2-yl]methyl]methanamine, CHLORIDE ION, MAGNESIUM ION, ... 著者 Nichols, C.E, De Nicola, G.F. 登録日 2019-08-28 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
3OD6	Crystal structure of p38alpha Y323T active mutant 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Livnah, O, Tzarum, N. 登録日 2010-08-11 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.682 Å) 主引用文献 Active mutants of the TCR-mediated p38alpha alternative activation site show changes in the phosphorylation lip and DEF site formation. J.Mol.Biol., 405, 2011

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