8OTN
 
 | | structure of InhA from mycobacterium tuberculosis in complex with inhibitor 7-((1-(3-Hydroxy-4-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methyl-2H-chromen-2-one | | 分子名称: | 4-methyl-7-[[1-[(3-oxidanyl-4-phenoxy-phenyl)methyl]-1,2,3-triazol-4-yl]methoxy]chromen-2-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Chebaiki, M, Maveyraud, L, Tamhaev, R, Lherbet, C, Mourey, L. | | 登録日 | 2023-04-21 | | 公開日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.962 Å) | | 主引用文献 | Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur.J.Med.Chem., 259, 2023
|
|
6FV3
 | | Crystal structure of N-acetyl-D-glucosamine-6-phosphate deacetylase from Mycobacterium smegmatis. | | 分子名称: | N-acetylglucosamine-6-phosphate deacetylase, ZINC ION | | 著者 | Ahangar, M.S, Furze, C.M, Guy, C.S, Cooper, C, Maskew, K.S, Graham, B, Cameron, A.D, Fullam, E. | | 登録日 | 2018-02-28 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
J. Biol. Chem., 293, 2018
|
|
7R50
 | |
8CGA
 | | Structure of Mycobacterium tuberculosis dUTPase delta 133A-137S mutant | | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | | 著者 | Toth, Z.S, Benedek, A, Leveles, I, Vertessy, B.G. | | 登録日 | 2023-02-03 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The homodimerization domain of the Stl repressor is crucial for efficient inhibition of mycobacterial dUTPase.
Sci Rep, 14, 2024
|
|
6H2T
 | | GlnH bound to Glu, Mycobacterium tuberculosis | | 分子名称: | GLUTAMIC ACID, Probable glutamine-binding lipoprotein GlnH (GLNBP) | | 著者 | O'Hare, H.M, Wallis, R, Lin, L.Y, Newland-Smith, Z. | | 登録日 | 2018-07-16 | | 公開日 | 2018-07-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | An Aspartate-Specific Solute-Binding Protein Regulates Protein Kinase G Activity To Control Glutamate Metabolism in Mycobacteria.
MBio, 9, 2018
|
|
8ODQ
 | | SufS-SufU complex from Mycobacterium tuberculosis | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Cysteine desulfurase, NITRATE ION, ... | | 著者 | Elchennawi, I, Carpentier, P, Caux, C, Ponge, M, Ollagnier de Choudens, S. | | 登録日 | 2023-03-09 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-06-07 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural and Biochemical Characterization of Mycobacterium tuberculosis Zinc SufU-SufS Complex.
Biomolecules, 13, 2023
|
|
6G7D
 | |
6G80
 | |
6NNC
 | | Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pemetrexed | | 分子名称: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, COBALT (II) ION, Dihydrofolate reductase, ... | | 著者 | Ribeiro, J.A, Chavez-Pacheco, S.M, Dias, M.V.B. | | 登録日 | 2019-01-14 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
6NNH
 | | Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil | | 分子名称: | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, COBALT (II) ION, Dihydrofolate reductase, ... | | 著者 | Giudice, J.H.P, Ribeiro, J.A, Dias, M.V.B. | | 登録日 | 2019-01-15 | | 公開日 | 2019-07-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.523 Å) | | 主引用文献 | Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
7RB1
 | | Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid | | 分子名称: | (3E)-3-(hydroxyimino)propanoic acid, GLYCEROL, GLYOXYLIC ACID, ... | | 著者 | Krieger, I.V, Mellott, D, Meek, T, Sacchettini, J.C. | | 登録日 | 2021-07-05 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2 R ,3 S )-2-Hydroxy-3-(nitromethyl)succinic acid.
J.Am.Chem.Soc., 143, 2021
|
|
6H2C
 | | Structure of BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct derived from clavulanic acid. | | 分子名称: | (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, ACETATE ION, Beta-lactamase, ... | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2018-07-13 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | New Conformations of Acylation Adducts of Inhibitors of beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 58, 2019
|
|
6H2I
 | |
6NNI
 | | Structure of closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pyrimethamine | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, COBALT (II) ION, ... | | 著者 | Ribeiro, J.A, Chavez-Pacheco, S.M, Dias, M.V.B. | | 登録日 | 2019-01-15 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.561 Å) | | 主引用文献 | Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
6NND
 | | Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and dihydrofolate | | 分子名称: | COBALT (II) ION, DIHYDROFOLIC ACID, Dihydrofolate reductase, ... | | 著者 | Ribeiro, J.A, Chavez-Pacheco, S.M, Dias, M.V.B. | | 登録日 | 2019-01-14 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.
Acta Crystallogr D Struct Biol, 75, 2019
|
|
6H2K
 | | Structure of BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam. | | 分子名称: | ACETATE ION, Beta-lactamase, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2018-07-13 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | New Conformations of Acylation Adducts of Inhibitors of beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 58, 2019
|
|
6H2H
 | | Structure of BlaC from Mycobacterium tuberculosis covalently bound to avibactam. | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, POLYETHYLENE GLYCOL (N=34) | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2018-07-13 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | New Conformations of Acylation Adducts of Inhibitors of beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 58, 2019
|
|
6H2G
 | |
6H28
 | | Structure of S70A BlaC from Mycobacterium tuberculosis obtained from crystals produced in the absence of DTT | | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2018-07-13 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | New Conformations of Acylation Adducts of Inhibitors of beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 58, 2019
|
|
6H2A
 | | Structure of S70A BlaC from Mycobacterium tuberculosis obtained from crystals produced in the presence of DTT | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Beta-lactamase, GLYCEROL, ... | | 著者 | Tassoni, R, Pannu, N.S, Ubbink, M. | | 登録日 | 2018-07-13 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | New Conformations of Acylation Adducts of Inhibitors of beta-Lactamase from Mycobacterium tuberculosis.
Biochemistry, 58, 2019
|
|
6HOE
 | |
6HNX
 | |
6HO1
 | |
6HO5
 | |
7PU7
 | | DNA polymerase from M. tuberculosis | | 分子名称: | DNA polymerase III subunit alpha, Template, ZINC ION, ... | | 著者 | Borsellini, A, Lamers, M.H. | | 登録日 | 2021-09-28 | | 公開日 | 2022-02-23 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis.
Acs Infect Dis., 8, 2022
|
|
