6NNH

Structure of Closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and cycloguanil

Summary for 6NNH

Entry DOI	10.2210/pdb6nnh/pdb
Descriptor	Dihydrofolate reductase, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	antifolate, biosynthetic protein
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	38006.53
Authors	Giudice, J.H.P.,Ribeiro, J.A.,Dias, M.V.B. (deposition date: 2019-01-15, release date: 2019-07-17, Last modification date: 2023-10-11)
Primary citation	Ribeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. Acta Crystallogr D Struct Biol, 75:682-693, 2019 Cited by PubMed: 31282477 DOI: 10.1107/S205979831900901X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.523 Å)

Structure validation