PDB: 82203 件ウェブページステータス検索Chemie searchBIRD

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5AQJ	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9H-purine-6,8-diamine, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AQF	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
4LFM	Crystal Structure of D-galactose-6-phosphate isomerase in complex with D-psicose 分子名称: D-psicose, Galactose-6-phosphate isomerase subunit A, Galactose-6-phosphate isomerase subunit B 著者 Jung, W.S, Pan, C.H. 登録日 2013-06-27 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. Plos One, 8, 2013
5AQK	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, DIMETHYL SULFOXIDE, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AQQ	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 7-methylquinazolin-4-amine, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AQR	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-methoxyquinazolin-4-amine, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... 著者 Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. 登録日 2015-09-22 公開日 2016-10-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
4LFK	Crystal Structure of D-galactose-6-phosphate isomerase in a substrate-free form 分子名称: Galactose-6-phosphate isomerase subunit A, Galactose-6-phosphate isomerase subunit B 著者 Jung, W.S, Pan, C.H. 登録日 2013-06-27 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. Plos One, 8, 2013
4LFL	Crystal Structure of D-galactose-6-phosphate isomerase in complex with D-tagatose-6-phosphate 分子名称: 6-O-phosphono-D-tagatose, Galactose-6-phosphate isomerase subunit A, Galactose-6-phosphate isomerase subunit B 著者 Jung, W.S, Pan, C.H. 登録日 2013-06-27 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. Plos One, 8, 2013
4LN5	Crystal structure of a trap periplasmic solute binding protein from burkholderia ambifaria (Bamb_6123), TARGET EFI-510059, with bound glycerol and chloride ion 分子名称: CHLORIDE ION, GLYCEROL, TRAP dicarboxylate transporter, ... 著者 Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2013-07-11 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry, 54, 2015
4LFN	Crystal Structure of D-galactose-6-phosphate isomerase in complex with D-ribulose 分子名称: D-ribulose, Galactose-6-phosphate isomerase subunit A, Galactose-6-phosphate isomerase subunit B 著者 Jung, W.S, Pan, C.H. 登録日 2013-06-27 公開日 2013-11-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure and substrate specificity of D-galactose-6-phosphate isomerase complexed with substrates. Plos One, 8, 2013
3RSV	Structure of Bace-1 (Beta-Secretase) in complex with (R)-3-(2-amino-6-o-tolylquinolin-3-yl)-N-((R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-methylpropanamide 分子名称: (2R)-3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-[(4R)-2,2-dimethyltetrahydro-2H-pyran-4-yl]-2-methylpropanamide, Beta-secretase 1, GLYCEROL, ... 著者 Sickmier, E.A. 登録日 2011-05-02 公開日 2011-08-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
4OST	Crystal structure of the S505C mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
3RTM	Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide 分子名称: 3-(2-aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide, Beta-secretase 1, GLYCEROL, ... 著者 Sickmier, E.A. 登録日 2011-05-03 公開日 2011-08-31 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
4OSK	Crystal structure of TAL effector reveals the recognition between asparagine and guanine 分子名称: DNA (5'-D(*AP*GP*TP*CP*TP*AP*GP*TP*AP*GP*TP*TP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*AP*AP*CP*TP*AP*CP*TP*AP*GP*AP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.398 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
4OT0	Crystal structure of the S505T mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.491 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
3QKQ	Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2011-02-01 公開日 2012-08-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B. Arch.Biochem.Biophys., 525, 2012
3RTN	Structure of Bace-1 (Beta-Secretase) in Complex with 3-(2-Amino-6-o-tolylquinolin-3-yl)-N-cyclohexylpropanamide 分子名称: 3-[2-amino-6-(2-methylphenyl)quinolin-3-yl]-N-cyclohexylpropanamide, Beta-secretase 1, GLYCEROL, ... 著者 Sickmier, E.A. 登録日 2011-05-03 公開日 2011-08-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54, 2011
3R8X	Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, METHIONINE, ... 著者 Maltseva, N, Kim, Y, Hasseman, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2011-03-24 公開日 2011-04-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.256 Å) 主引用文献 Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine To be Published
4OSL	Crystal structure of TAL effector reveals the recognition between histidine and guanine 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*CP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*GP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3, ... 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.447 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
4OT3	Crystal structure of the S505L mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.944 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
4OSV	Crystal structure of the S505M mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
4OSM	Crystal structure of the S505H mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.454 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
3U41	Crystal structure of Escherichia coli DmsD in space group P212121 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Stevens, C.M, Paetzel, M. 登録日 2011-10-06 公開日 2013-02-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献
4OSI	Crystal structure of the TAL effector dHax3 with NI RVD at 2.8 angstrom resolution 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.849 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014
4OSZ	Crystal structure of the S505P mutant of TAL effector dHax3 分子名称: DNA (5'-D(*AP*GP*AP*GP*AP*GP*AP*TP*AP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*TP*AP*TP*CP*TP*CP*TP*CP*T)-3'), Hax3 著者 Deng, D, Wu, J.P, Yan, C.Y, Pan, X.J, Yan, N. 登録日 2014-02-13 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.614 Å) 主引用文献 Revisiting the TALE repeat Protein Cell, 5, 2014

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