PDB: 10604 件ウェブページステータス検索Chemie searchBIRD

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6S41	CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455 分子名称: 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 著者 Focken, T, Maskos, K, Griessner, A, Krapp, S. 登録日 2019-06-26 公開日 2019-10-02 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J.Med.Chem., 62, 2019
7A6V	Human Carbonic Anhydrase II in complex with 4-(3-(3-phenoxypropyl)thioureido)benzenesulfonamide 分子名称: 4-(3-(3-phenoxypropyl)thioureido)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Angeli, A, Ferraroni, M. 登録日 2020-08-26 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. Chemistry, 28, 2022
6RHJ	Crystal structure of human carbonic anhydrase isozyme II with 4-(4-benzyl-1,4-diazepane-1-carbonyl)benzenesulfonamide 分子名称: 4-[[4-(phenylmethyl)-1,4-diazepan-1-yl]carbonyl]benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Ferraroni, M, Angeli, A, Supuran, C.T. 登録日 2019-04-21 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. Bioorg.Chem., 91, 2019
6RG4	Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzyl-4-methylpiperazin-1-yl)benzenesulfonamide 分子名称: 4-[(3~{S})-4-methyl-3-(phenylmethyl)piperazin-1-yl]carbonylbenzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Ferraroni, M, Angeli, A, Supuran, C. 登録日 2019-04-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. Bioorg.Chem., 91, 2019
7P76	Re-engineered 2-deoxy-D-ribose-5-phosphate aldolase catalysing asymmetric Michael addition reactions, Schiff base complex with cinnamaldehyde 分子名称: (2E)-3-phenylprop-2-enal, Deoxyribose-phosphate aldolase, GLYCEROL 著者 Thunnissen, A.M.W.H, Rozeboom, H.J, Kunzendorf, A, Poelarends, G.J. 登録日 2021-07-19 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution. Acs Catalysis, 11, 2021
7P75	Re-engineered 2-deoxy-D-ribose-5-phosphate aldolase catalysing asymmetric Michael addition reactions in substrate-free state 分子名称: Deoxyribose-phosphate aldolase 著者 Thunnissen, A.M.W.H, Rozeboom, H.J, Kunzendorf, A, Poelarends, G.J. 登録日 2021-07-19 公開日 2021-10-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution. Acs Catalysis, 11, 2021
6WC6	Crystal structure of a truncated LSD1:CoREST in the presence of an LSD1-NT peptide 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LSD1-NT peptide, Lysine-specific histone demethylase 1A, ... 著者 Reiter, N.J, Zeng, D, Senanayaka, D. 登録日 2020-03-29 公開日 2021-06-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Identification of structure and nucleosome binding within the N-terminus of lysine specific demethylase 1 To Be Published
5KKU	Crystal structure of an N-terminal dehydratase from difficidin assembly line 分子名称: Polyketide synthase type I 著者 Keatinge-Clay, A.T, Zeng, J. 登録日 2016-06-22 公開日 2016-12-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 A Dehydratase Provides Insights into Split Bimodules and Polypeptide Docking in trans-AT Polyketide Synthases To Be Published
8BJX	Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide 分子名称: 1-[(3~{R})-1-(6-nitropyridin-2-yl)pyrrolidin-3-yl]-3-(4-sulfamoylphenyl)thiourea, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Angeli, A, Ferraroni, M. 登録日 2022-11-08 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.283 Å) 主引用文献 Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide To Be Published
8CDZ	human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide 分子名称: 1-butyl-3-(4-sulfamoylphenyl)urea, Carbonic anhydrase 1, DIMETHYL SULFOXIDE, ... 著者 Angeli, A, Ferraroni, M. 登録日 2023-02-01 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide To Be Published
3PCW	Endothiapepsin in complex with a fragment 分子名称: 4-(trifluoromethyl)benzenecarboximidamide, DIMETHYL SULFOXIDE, Endothiapepsin, ... 著者 Koester, H, Heine, A, Klebe, G. 登録日 2010-10-22 公開日 2011-10-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes. J.Med.Chem., 54, 2011
4OVW	ENDOGLUCANASE I COMPLEXED WITH EPOXYBUTYL CELLOBIOSE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(beta-D-glucopyranosyloxy)-2,2-dihydroxybutyl propanoate, ENDOGLUCANASE I 著者 Davies, G.J, Schulein, M. 登録日 1997-10-06 公開日 1998-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the endoglucanase I from Fusarium oxysporum: native, cellobiose, and 3,4-epoxybutyl beta-D-cellobioside-inhibited forms, at 2.3 A resolution. Biochemistry, 36, 1997
1MYP	X-RAY CRYSTAL STRUCTURE OF CANINE MYELOPEROXIDASE AT 3 ANGSTROMS RESOLUTION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, MYELOPEROXIDASE, ... 著者 Fenna, R.E, Zeng, J. 登録日 1992-04-15 公開日 1994-01-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 X-ray crystal structure of canine myeloperoxidase at 3 A resolution. J.Mol.Biol., 226, 1992
4J7V	Crystal structure of cross-linked hen egg white lysozyme soaked with 5mM [Ru(benzene)Cl2]2 分子名称: Benzeneruthenium(II) chloride, CHLORIDE ION, Lysozyme C, ... 著者 Tabe, H, Abe, S, Hikage, T, Kitagawa, S, Ueno, T. 登録日 2013-02-14 公開日 2014-02-19 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Solid Artificial Metalloenzymes: Post-Engineering of Porous Protein Crystals by Organometallic Complexes To be Published
1QJH	Protein Aggregation and Alzheimer's Disease: Crystallographic Analysis of the Phenomenon. Engineered version of the ribosomal protein S6 used as a stable scaffold to study oligomerization. 分子名称: 30S ribosomal protein S6, MAGNESIUM ION 著者 Kristensen, O, Otzen, D.E, Oliveberg, M. 登録日 1999-06-24 公開日 2000-06-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: a structural clue to amyloid assembly. Proc. Natl. Acad. Sci. U.S.A., 97, 2000
5FAI	EMG1 N1-Specific Pseudouridine Methyltransferase 分子名称: CITRIC ACID, Ribosomal RNA small subunit methyltransferase NEP1, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 DONG, A, ZENG, H, LI, Y, TEMPEL, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) 登録日 2015-12-11 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 EMG1 N1-Specific Pseudouridine Methyltransferase to be published
2ISA	Crystal Structure of Vibrio salmonicida catalase 分子名称: CHLORIDE ION, Catalase, GLYCEROL, ... 著者 Riise, E.K, Lorentzen, M.S, Helland, R, Smalas, A.O, Leiros, H.K.S, Willassen, N.P. 登録日 2006-10-17 公開日 2007-01-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 The first structure of a cold-active catalase from Vibrio salmonicida at 1.96A reveals structural aspects of cold adaptation ACTA CRYSTALLOGR.,SECT.D, 63, 2007
2L8J	GABARAPL-1 NBR1-LIR complex structure 分子名称: Gamma-aminobutyric acid receptor-associated protein-like 1, NBR1-LIR peptide 著者 Rogov, V.V, Rozenknop, A, Rogova, N.Y, Loehr, F, Guentert, P, Dikic, I, Doetsch, V. 登録日 2011-01-17 公開日 2011-05-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1. J.Mol.Biol., 410, 2011
5KYC	Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound) 分子名称: GLYCEROL, MALONIC ACID, Polyubiquitin-B, ... 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.426 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
5KYF	Crystal structure of USP7 catalytic domain [L299A] mutant in complex with ubiquitin 分子名称: GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
4NBM	Crystal structure of UVB photoreceptor UVR8 and light-induced structural changes at 180K 分子名称: MAGNESIUM ION, Ultraviolet-B receptor UVR8 著者 Yang, X, Zeng, X, Zhao, K.-H, Ren, Z. 登録日 2013-10-23 公開日 2016-10-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Dynamic Crystallography Reveals Early Signalling Events in Ultraviolet Photoreceptor UVR8. Nat Plants, 1, 2015
5L3A	Fragment-based discovery of 6-arylindazole JAK inhibitors 分子名称: Tyrosine-protein kinase JAK2, ~{N}-(1~{H}-indazol-4-yl)methanesulfonamide 著者 Soerensen, M.D, Dack, K.N, Greve, D.R, Ritzen, A. 登録日 2016-04-06 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Fragment-Based Discovery of 6-Arylindazole JAK Inhibitors. Acs Med.Chem.Lett., 7, 2016
5KKP	Crystal Structure of Human Pseudouridylate Synthase 7 分子名称: 1,2-ETHANEDIOL, Pseudouridylate synthase 7, UNKNOWN ATOM OR ION 著者 DONG, A, ZENG, H, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) 登録日 2016-06-22 公開日 2016-08-17 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystal Structure of Human Pseudouridylate Synthase 7 to be published
5KYE	Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
5KYB	Crystal structure of the apo-form of USP7 catalytic domain [V302K] mutant 分子名称: GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018

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