6ZI5
 
 | | Ultrafast Structural Response to Charge Redistribution Within a Photosynthetic Reaction Centre - 300 ps (a) structure | | 分子名称: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | | 著者 | Baath, P, Dods, R, Braenden, G, Neutze, R. | | 登録日 | 2020-06-24 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ultrafast structural changes within a photosynthetic reaction centre.
Nature, 589, 2021
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6QQK
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6ZIA
 | | Ultrafast Structural Response to Charge Redistribution Within a Photosynthetic Reaction Centre - 8 us structure | | 分子名称: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | | 著者 | Baath, P, Dods, R, Braenden, G, Neutze, R. | | 登録日 | 2020-06-25 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ultrafast structural changes within a photosynthetic reaction centre.
Nature, 589, 2021
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3UVE
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6D8J
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3HYC
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6QQI
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6A4G
 | | Mandelate oxidase mutant-Y128F with the monooxide FMN adduct | | 分子名称: | 1-deoxy-1-[(4aS)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | 著者 | Li, T.L, Lin, K.H. | | 登録日 | 2018-06-19 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6QNC
 | | Liquid Application Method for time-resolved Analyses (LAMA) by serial synchrotron crystallography, Xylose Isomerase 0.1 s timepoint | | 分子名称: | COBALT (II) ION, MAGNESIUM ION, Xylose isomerase, ... | | 著者 | Mehrabi, P, Schulz, E.C, Miller, R.J.D. | | 登録日 | 2019-02-10 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Nat.Methods, 16, 2019
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4UIO
 | | Structure of the Salmonella typhi Type I Dehydroquinase covalently inhibited by a 3-dehydroquinic acid derivative | | 分子名称: | (1~{R},3~{R},4~{S},5~{R})-3-methyl-1,3,4,5-tetrakis(oxidanyl)cyclohexane-1-carboxylic acid, 3-DEHYDROQUINATE DEHYDRATASE, CHLORIDE ION, ... | | 著者 | Otero, J.M, Llamas-Saiz, A.L, Tizon, L, Lence, E, Thompson, P, Hawkins, A.R, Gonzalez-Bello, C, van Raaij, M.J. | | 登録日 | 2015-03-30 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.
J.Am.Chem.Soc., 137, 2015
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6QNH
 | | Liquid Application Method for time-resolved Analyses (LAMA) by serial synchrotron crystallography, Xylose Isomerase 0ms timepoint | | 分子名称: | COBALT (II) ION, MAGNESIUM ION, Xylose isomerase | | 著者 | Mehrabi, P, Schulz, E.C, Miller, R.J.D. | | 登録日 | 2019-02-11 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Liquid application method for time-resolved analyses by serial synchrotron crystallography.
Nat.Methods, 16, 2019
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6AHE
 | | Crystal structure of enoyl-ACP reductase from Acinetobacter baumannii in complex with NAD and AFN-1252 | | 分子名称: | Enoyl-[acyl-carrier-protein] reductase [NADH], N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Rani, S.T, Nataraj, V, Laxminarasimhan, A, Thomas, A, Krishnamurthy, N. | | 登録日 | 2018-08-17 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Ternary complex formation of AFN-1252 with Acinetobacter baumannii FabI and NADH: Crystallographic and biochemical studies.
Chem.Biol.Drug Des., 96, 2020
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8SR7
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | | 分子名称: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (1.97 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Nat.Struct.Mol.Biol., 2024
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6A1R
 | | Mandelate oxidase mutant-Y128F with the N5-phenylacetyl-FMN adduct | | 分子名称: | 1-deoxy-1-[7,8-dimethyl-2,4-dioxo-5-(phenylacetyl)-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase, MAGNESIUM ION | | 著者 | Li, T.L, Lin, K.H. | | 登録日 | 2018-06-08 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | | 主引用文献 | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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8CR2
 | | Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer | | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1, ZINC ION | | 著者 | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | | 登録日 | 2023-03-07 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8CR1
 | | Homo sapiens Get1/Get2 heterotetramer in complex with a Get3 dimer | | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1,GET2-GET1, ZINC ION | | 著者 | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | | 登録日 | 2023-03-07 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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6A3D
 | | The crystal structure of Mandelate oxidase Y128F with 4-Br-2-hydroxy-methylphenylacetate | | 分子名称: | 1-deoxy-1-[(4aS)-4a-[(methoxycarbonyl)peroxy]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | 著者 | Li, T.L, Lin, K.H. | | 登録日 | 2018-06-15 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.923 Å) | | 主引用文献 | Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.
Protein Sci., 29, 2020
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6A3T
 | | The crystal structure of Mandelate oxidase R163L with 2-hydroxy-phenylacetamide | | 分子名称: | 1-{5-[(1S)-2-amino-1-hydroxy-2-oxo-1-phenylethyl]-7,8-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrobenzo[g]pteridine-5,10-diium-10-yl}-1-deoxy-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | 著者 | Li, T.L, Lin, K.H. | | 登録日 | 2018-06-16 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.511 Å) | | 主引用文献 | The flavin mononucleotide cofactor in alpha-hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate-oxidation level.
Acta Crystallogr D Struct Biol, 75, 2019
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6AI7
 | | Mandelate oxidase mutant-Y128F with the C4a-OH-FMN adduct | | 分子名称: | 1-deoxy-1-[(4aS)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, 4-hydroxymandelate oxidase | | 著者 | Li, T.L, Lin, K.H. | | 登録日 | 2018-08-21 | | 公開日 | 2019-08-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | The crystal structure of Mandelate oxidase mutant-Y128F with the C4a-OH-FMN adduct
To Be Published
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5W92
 | | Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049 | | 分子名称: | 1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one, 2-[(2S)-1-(3,5-dichloropyridine-4-carbonyl)pyrrolidin-2-yl]-5-hydroxy-6-oxo-N-[2-(phenylsulfonyl)ethyl]-1,6-dihydropyrimidine-4-carboxamide, MANGANESE (II) ION, ... | | 著者 | Kumar, G, White, S. | | 登録日 | 2017-06-22 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.
Sci Rep, 7, 2017
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5W2W
 | | INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 8-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID | | 分子名称: | (2R,3R,4R,5R,6R)-5-acetamido-6-[(1R)-1,3-bis(oxidanyl)propyl]-2,3-bis(fluoranyl)-4-oxidanyl-oxane-2-carboxylic acid, (2~{R},3~{R},4~{R},5~{R})-3-acetamido-2-[(1~{R})-1,3-bis(oxidanyl)propyl]-5-fluoranyl-4-oxidanyl-2,3,4,5-tetrahydropyran-1-ium-6-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Streltsov, V.A, Mckimm-Breschkin, J, Barrett, S, Pilling, P, Hader, S, Watt, A.G. | | 登録日 | 2017-06-07 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
J. Med. Chem., 61, 2018
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8IQ9
 | | Crystal structure of trimeric K2-2 TSP in complex with tetrasaccharide and octasaccharide | | 分子名称: | 1,2-ETHANEDIOL, ACETYL GROUP, K2-2 TSP, ... | | 著者 | Ye, T.J, Ko, T.P, Huang, K.F, Wu, S.H. | | 登録日 | 2023-03-16 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation.
Mbio, 15, 2024
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7BGQ
 | | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1019 | | 分子名称: | 14-3-3 protein sigma, 2-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... | | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | | 登録日 | 2021-01-08 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
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7BGR
 | | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1016 | | 分子名称: | 14-3-3 protein sigma, 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... | | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | | 登録日 | 2021-01-08 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
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7BDP
 | | 14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1017 | | 分子名称: | 14-3-3 protein sigma, 2-chloranyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... | | 著者 | Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. | | 登録日 | 2020-12-22 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
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