PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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6Q4H	CDK2 in complex with FragLite36 分子名称: 2-[3-[(2-azanyl-9~{H}-purin-6-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6JEZ	Covalent labeling of rVDR-LBD by turn-on fluorescent probe mediated by conjugate addition and cyclization 分子名称: (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2- methylenecyclohexane-1,3-diol, 7-(diethylamino)chromen-2-one, Mediator of RNA polymerase II transcription subunit 1, ... 著者 Kojima, H, Yamamoto, K, Itoh, T. 登録日 2019-02-07 公開日 2020-02-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins. Cell Chem Biol, 27, 2020
6Q4E	CDK2 in complex with FragLite33 分子名称: 6-iodanyl-7~{H}-purin-2-amine, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4K	CDK2 in complex with FragLite38 分子名称: (~{E})-3-[3-[(4-chlorophenyl)carbamoyl]phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
1C0O	SOLUTION STRUCTURE OF THE P5 HAIRPIN FROM A GROUP I INTRON COMPLEXED WITH COBALT (III) HEXAMMINE, NMR, 19 CONVERGED STRUCTURES 分子名称: COBALT HEXAMMINE(III), RNA (5'-R(*GP*GP*GP*UP*CP*UP*UP*CP*GP*GP*GP*UP*CP*C)-3') 著者 Colmenarejo, G, Tinoco Jr, I. 登録日 1999-03-16 公開日 1999-08-31 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Structure and thermodynamics of metal binding in the P5 helix of a group I intron ribozyme. J.Mol.Biol., 290, 1999
6K5O	Development of Novel Lithocholic Acid Derivatives as Vitamin D Receptor Agonists 分子名称: (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-3-methylsulfonyloxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Masuno, H, Kagechika, H, Ito, N. 登録日 2019-05-29 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Development of novel lithocholic acid derivatives as vitamin D receptor agonists. Bioorg.Med.Chem., 27, 2019
1C9B	CRYSTAL STRUCTURE OF A HUMAN TBP CORE DOMAIN-HUMAN TFIIB CORE DOMAIN COMPLEX BOUND TO AN EXTENDED, MODIFIED ADENOVIRAL MAJOR LATE PROMOTER (ADMLP) 分子名称: ADMLP TATA-BOX DNA CONTAINING IIB RECOGNITION ELEMENT, GENERAL TRANSCRIPTION FACTOR IIB, TATA BOX BINDING PROTEIN 著者 Tsai, F.T.F, Sigler, P.B. 登録日 1999-08-01 公開日 2000-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis of preinitiation complex assembly on human pol II promoters. EMBO J., 19, 2000
6ALY	Solution structure of yeast Med15 ABD2 residues 277-368 分子名称: Mediator of RNA polymerase II transcription subunit 15 著者 Tuttle, L.M, Pacheco, D, Warfield, L, Hahn, S, Klevit, R.E. 登録日 2017-08-08 公開日 2018-03-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex. Cell Rep, 22, 2018
6GXZ	Crystal structure of the human RPAP3(TPR2)-PIH1D1(CS) complex 分子名称: CALCIUM ION, PIH1 domain-containing protein 1, RNA polymerase II-associated protein 3 著者 Henri, J, Quinternet, M, Manival, X, Chagot, M.-E, Charpentier, B, Meyer, P. 登録日 2018-06-27 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.965 Å) 主引用文献 Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
4XR8	Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution 分子名称: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, ... 著者 Martinez-Zapien, D, Ruiz, F.X, Mitschler, A, Podjarny, A, Trave, G, Zanier, K. 登録日 2015-01-20 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature, 529, 2016
3NGI	RB69 DNA Polymerase (Y567A) Ternary Complex with dTTP Opposite dG 分子名称: CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), DNA (5'-D(*TP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ... 著者 Wang, M, Wang, J, Konigsberg, W.H. 登録日 2010-06-11 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.886 Å) 主引用文献 Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures. J.Mol.Biol., 406, 2011
6Q3F	CDK2 in complex with FragLite2 分子名称: 4-bromanylpyridin-2-amine, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-04 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4D	CDK2 in complex with FragLite31 分子名称: 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4C	CDK2 in complex with FragLite16 分子名称: 4-bromanyl-1,8-naphthyridine, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4F	CDK2 in complex with FragLite32 分子名称: Cyclin-dependent kinase 2, PYRIDINE-2,6-DIAMINE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.21 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4A	CDK2 in complex with FragLite14 分子名称: 5-iodanylpyrimidine, CYCLIN-DEPENDENT KINASE 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
6Q4I	CDK2 in complex with FragLite35 分子名称: 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
3CFO	Triple Mutant APO structure 分子名称: DNA polymerase, GUANOSINE, SULFATE ION 著者 Wang, J, Klimenko, D, Wang, M, Steitz, T.A, Konigsberg, W.H. 登録日 2008-03-04 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant To be Published
6R0L	Histone fold domain of OsGhd8/NF-YC7 in I2 分子名称: GLYCEROL, OsGhd8, OsNF-YC7 著者 Chaves-Sanjuan, A, Gobbini, A, Nardini, M. 登録日 2019-03-13 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants. Plant J., 105, 2021
6FDP	NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP90 peptide DTSRMEEVD 分子名称: Heat shock protein HSP 90-alpha, RNA polymerase II-associated protein 3 著者 Quinternet, M, Chagot, M.E, Manival, X. 登録日 2017-12-26 公開日 2018-08-01 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
1KEJ	Crystal Structure of Murine Terminal Deoxynucleotidyl Transferase complexed with ddATP 分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, COBALT (II) ION, SODIUM ION, ... 著者 Delarue, M, Boule, J.B, Lescar, J, Expert-Bezancon, N, Jourdan, N, Sukumar, N, Rougeon, F, Papanicolaou, C. 登録日 2001-11-16 公開日 2002-05-16 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase. EMBO J., 21, 2002
6FDT	NMR structure of the second TPR domain of the human RPAP3 protein in complex with HSP70 peptide SGPTIEEVD 分子名称: Heat shock 70 kDa protein 1B, RNA polymerase II-associated protein 3 著者 Quinternet, M, Chagot, M.E, Manival, X. 登録日 2017-12-26 公開日 2018-08-01 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure, 26, 2018
4A8J	Crystal Structure of the Elongator subcomplex Elp456 分子名称: ELONGATOR COMPLEX PROTEIN 4, ELONGATOR COMPLEX PROTEIN 5, ELONGATOR COMPLEX PROTEIN 6 著者 Glatt, S, Mueller, C.W. 登録日 2011-11-21 公開日 2012-02-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Elongator Subcomplex Elp456 is a Hexameric Reca-Like ATPase. Nat.Struct.Mol.Biol., 19, 2012
3I8W	Crystal structure of a metallacarborane inhibitor bound to HIV protease 分子名称: CHLORIDE ION, COBALT BIS(1,2-DICARBOLLIDE), GLYCEROL, ... 著者 Rezacova, P. 登録日 2009-07-10 公開日 2009-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes J.Med.Chem., 52, 2009
2VB0	Crystal structure of coxsackievirus B3 proteinase 3C 分子名称: CHLORIDE ION, POLYPROTEIN 3BCD 著者 Anand, K, Mesters, J.R, Goerlach, R, Zell, R, Hilgenfeld, R. 登録日 2007-09-05 公開日 2008-10-28 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Coxsackie Virus B3 Proteinase 3C To be Published

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