PDB: 61223 件ウェブページステータス検索Chemie searchBIRD

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6IIT	Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me2-containing histone peptide 分子名称: 16-bp TA-rich DNA, H3K36me2-containing histone peptide, Hepatoma-derived growth factor-related protein 3 著者 Wang, Z, Tian, W. 登録日 2018-10-07 公開日 2019-04-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and a H3K36me2-containing histone peptide Nucleic Acids Res., 2019
4USU	Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate 分子名称: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... 著者 Kleinboelting, S, Steegborn, C. 登録日 2014-07-13 公開日 2014-07-30 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
5ZM7	Crystal structure of ORP1-ORD in complex with cholesterol at 3.4 A resolution 分子名称: CHOLESTEROL, Oxysterol-binding protein-related protein 1 著者 Dong, J, Wang, J, Wu, J.W. 登録日 2018-04-01 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.401 Å) 主引用文献 Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun, 10, 2019
6PUF	Structure of human MAIT A-F7 TCR in complex with human MR1-5'D-5-OP-RU 分子名称: 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6PUM	Structure of human MAIT A-F7 TCR in complex with human MR1-2'D-5-OP-RU 分子名称: 1,2-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6PUK	Structure of human MAIT A-F7 TCR in complex with human MR1-JYM72 分子名称: 1,2-dideoxy-1-{2,6-dioxo-5-[(1E)-3-oxobut-1-en-1-yl]-1,2,3,6-tetrahydropyrimidin-4-yl}-D-ribo-hexitol, ACETATE ION, Beta-2-microglobulin, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6PUL	Structure of human MAIT A-F7 TCR in complex with human MR1 3'D-5-OP-RU 分子名称: 1,3-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol, ACETATE ION, Beta-2-microglobulin, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6AAG	Crystal structure of budding yeast Atg8 complexed with the helical AIM of Hfl1. 分子名称: Transmembrane protein 184 homolog YKR051W,Autophagy-related protein 8 著者 Yamasaki, A, Noda, N.N. 登録日 2018-07-18 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.445 Å) 主引用文献 Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein Elife, 7, 2018
6PUE	Structure of human MAIT A-F7 TCR in complex with human MR1-4'D-5-OP-RU 分子名称: 1,4-dideoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-erythro-pentitol, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6PVC	Structure of human MAIT A-F7 TCR in complex with human MR1-DB28 分子名称: ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Rossjohn, J. 登録日 2019-07-20 公開日 2020-04-01 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Ligand-dependent downregulation of MR1 cell surface expression. Proc.Natl.Acad.Sci.USA, 117, 2020
6PVD	Structure of human MAIT A-F7 TCR in complex with human MR1-NV18.1 分子名称: ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Rossjohn, J. 登録日 2019-07-20 公開日 2020-04-01 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Ligand-dependent downregulation of MR1 cell surface expression. Proc.Natl.Acad.Sci.USA, 117, 2020
6Q7A	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 4 AT 2.2A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: 1-[2,6-bis(chloranyl)phenyl]-2-(furan-2-yl)-5-methyl-4-(phenylmethyl)imidazole, Nuclear receptor ROR-gamma 著者 Kallen, J. 登録日 2018-12-13 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
6Q6O	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: CHOLIC ACID, Nuclear receptor ROR-gamma, propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate 著者 Kallen, J. 登録日 2018-12-11 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
6TLM	ROR(gamma)t ligand binding domain in complex with allosteric ligand compound 13 (Glenmark) 分子名称: 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid, Nuclear receptor ROR-gamma 著者 de Vries, R.M.J.M, Meijer, F.A, Brunsveld, L. 登録日 2019-12-03 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.321 Å) 主引用文献 Elucidation of an Allosteric Mode of Action for a Thienopyrazole ROR gamma t Inverse Agonist. Chemmedchem, 15, 2020
6PUI	Structure of human MAIT A-F7 TCR in complex with human MR1-4'OH-Butyl-5-OP-U 分子名称: 6-[(4-hydroxybutyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, GLYCEROL, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6PUH	Structure of human MAIT A-F7 TCR in complex with human MR1-Ribityl-less 分子名称: 6-methyl-5-[(1E)-3-oxobut-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, Human TCR alpha chain, ... 著者 Awad, W, Keller, A.N, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
6Q7H	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 9 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: 1-[2,4-bis(chloranyl)-3-[2-(5-chloranylfuran-2-yl)-5-methyl-4-(trifluoromethyl)imidazol-1-yl]phenyl]azetidine-3-carboxylic acid, Nuclear receptor ROR-gamma 著者 Kallen, J. 登録日 2018-12-13 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019
6H2X	MukB coiled-coil elbow from E. coli 分子名称: Chromosome partition protein MukB,Chromosome partition protein MukB 著者 Buermann, F, Lowe, J. 登録日 2018-07-16 公開日 2019-03-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A folded conformation of MukBEF and cohesin. Nat.Struct.Mol.Biol., 26, 2019
6PUG	Structure of human MAIT A-F7 TCR in complex with human MR1-2`OH-Ethyl-5-OP-U 分子名称: 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione, Beta-2-microglobulin, CHLORIDE ION, ... 著者 Awad, W, Rossjohn, J. 登録日 2019-07-18 公開日 2020-02-19 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat.Immunol., 21, 2020
9C47	TRRAP module of the human TIP60 complex 分子名称: E1A-binding protein p400, Transformation/transcription domain-associated protein 著者 Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. 登録日 2024-06-03 公開日 2024-08-14 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
9C4B	Second BAF53a of the human TIP60 complex 分子名称: Actin-like protein 6A 著者 Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. 登録日 2024-06-03 公開日 2024-08-14 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
6CVH	Identification and biological evaluation of thiazole-based inverse agonists of RORgt 分子名称: Nuclear receptor ROR-gamma, trans-3-({4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-{[(2R)-1,1,1-trifluoropropan-2-yl]carbamoyl}phenyl]-1,3-thiazole-2-carbonyl}amino)cyclobutane-1-carboxylic acid 著者 Spurlino, J, Milligan, C. 登録日 2018-03-28 公開日 2018-04-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t. Bioorg. Med. Chem. Lett., 28, 2018
6B30	Structure of RORgt in complex with a novel inverse agonist 1 分子名称: N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide, Nuclear receptor ROR-gamma 著者 Skene, R.J, Hoffman, I. 登録日 2017-09-20 公開日 2018-01-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26, 2018
6TQS	The crystal structure of the MSP domain of human MOSPD2 in complex with the conventional FFAT motif of ORP1. 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 McEwen, A.G, Poussin-Courmontagne, P, Di Mattia, T, Wendling, C, Cavarelli, J, Tomasetto, C, Alpy, F. 登録日 2019-12-17 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. Embo J., 39, 2020
6Q6M	RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 1: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors 分子名称: Nuclear receptor ROR-gamma, ethyl (2~{S})-2-[(2-chloranyl-6-methyl-phenyl)-thiophen-2-ylcarbonyl-amino]propanoate 著者 Kallen, J. 登録日 2018-12-11 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors. J.Med.Chem., 62, 2019

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