7SF3
| SARS-CoV-2 Main Protease (Mpro) in Complex with ML1006m | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-3-hydroxy-4-(methylamino)-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase, CHLORIDE ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2021-10-02 | 公開日 | 2022-10-05 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med, 16, 2024
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7SFH
| SARS-CoV-2 Main Protease (Mpro) in Complex with ML102 | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-6,6-dimethyl-3-(3-phenylpropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase, CALCIUM ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2021-10-03 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases To Be Published
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7SET
| SARS-CoV-2 Main Protease (Mpro) in Complex with ML1000 | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase, CHLORIDE ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2021-10-01 | 公開日 | 2022-10-05 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med, 16, 2024
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8R8R
| Cryo-EM structure of the human mPSF with PAPOA C-terminus peptide (PAPOAc) | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*A)-3'), ... | 著者 | Todesca, S, Sandmeir, F, Keidel, A, Conti, E. | 登録日 | 2023-11-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Molecular basis of human poly(A) polymerase recruitment by mPSF. Rna, 30, 2024
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8G1L
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2LXN
| Solution NMR structure of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii | 分子名称: | GMP synthase [glutamine-hydrolyzing] subunit A | 著者 | Ali, R, Kumar, S, Balaram, H, Sarma, S.P. | 登録日 | 2012-08-30 | 公開日 | 2013-06-12 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii Biomol.Nmr Assign., 6, 2012
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6XYP
| Multiple system atrophy Type II-1 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6XYQ
| Multiple system atrophy Type II-2 alpha-synuclein filament | 分子名称: | Alpha-synuclein | 著者 | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2020-01-30 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
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6SPG
| Pseudomonas aeruginosa 70s ribosome from a clinical isolate | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Halfon, Y, Jimenez-Fernande, A, La Ros, R, Espinos, R, Krogh Johansen, H, Matzov, D, Eyal, Z, Bashan, A, Zimmerman, E, Belousoff, M, Molin, S, Yonath, A. | 登録日 | 2019-09-01 | 公開日 | 2019-10-16 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate. Proc.Natl.Acad.Sci.USA, 116, 2019
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4GXH
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8CLR
| Integrated NMR/MD structure determination of a dynamic and thermodynamically stable CUUG RNA tetraloop | 分子名称: | RNA hairpin with CUUG tetraloop | 著者 | Oxenfarth, A, Kuemmerer, F, Bottaro, S, Schnieders, R, Pinter, G, Jonker, H.R.A, Fuertig, B, Richter, C, Blackledge, M, Lindorff-Larsen, K, Schwalbe, H. | 登録日 | 2023-02-17 | 公開日 | 2023-07-19 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a Thermodynamically Stable CUUG RNA Tetraloop. J.Am.Chem.Soc., 145, 2023
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7BOT
| Human SIRT2 in complex with myristoyl thiourea inhibitor, No.23 | 分子名称: | N-dodecylmethanethioamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | 著者 | Kudo, N, Olsen, C.A, Minoru, Y. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chem Biol, 2, 2021
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6RPP
| Crystal structure of PabCDC21-1 intein | 分子名称: | ACETATE ION, Cell division control protein, DI(HYDROXYETHYL)ETHER | 著者 | Mikula, K.M, Beyer, H.M, Iwai, H. | 登録日 | 2019-05-14 | 公開日 | 2019-08-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site. Extremophiles, 23, 2019
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6RPQ
| Crystal structure of PhoCDC21-1 intein | 分子名称: | Ubiquitin-like protein SMT3,1108aa long hypothetical cell division control protein | 著者 | Beyer, H.M, Mikula, K.M, Iwai, H. | 登録日 | 2019-05-14 | 公開日 | 2019-08-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.654 Å) | 主引用文献 | Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site. Extremophiles, 23, 2019
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7BOS
| Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13 | 分子名称: | Myristoyl thiourea inhibitor, No.13, N-dodecylmethanethioamide, ... | 著者 | Kudo, N, Olsen, C.A, Minoru, Y. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chem Biol, 2, 2021
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9G8R
| human SKI7-SKI238 complex in the open state | 分子名称: | Isoform 2 of HBS1-like protein, Superkiller complex protein 2, Superkiller complex protein 3, ... | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | 登録日 | 2024-07-23 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex Nature, 2024
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9G8Q
| 40S-bound human SKI238 complex in the open state (Gatekeeping module) | 分子名称: | Helicase SKI2W, Superkiller complex protein 3, WD repeat-containing protein 61 | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | 登録日 | 2024-07-23 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex Nature, 2024
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9G8N
| 80S-bound human Ski2-exosome complex | 分子名称: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | 登録日 | 2024-07-23 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex Nature, 2024
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9G8P
| 40S-bound human SKI2-exosome complex | 分子名称: | CrPV-IRES RNA, DIS3-like exonuclease 1, Exosome complex component CSL4, ... | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | 登録日 | 2024-07-23 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex Nature, 2024
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9G8O
| human 40S ribosome bound by a SKI238-exosome complex | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | 登録日 | 2024-07-23 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex Nature, 2024
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7U92
| SARS-CoV-2 Main Protease (Mpro) in Complex with ML1006a | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-(azetidin-1-yl)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase, CHLORIDE ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2022-03-09 | 公開日 | 2023-09-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med, 16, 2024
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7UUG
| SARS-CoV-2 Main Protease S144A (Mpro S144A) in Complex with ML1006a | 分子名称: | (1R,2S,5S)-N-{(2S,3R)-4-(azetidin-1-yl)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, CHLORIDE ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2022-04-28 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med, 16, 2024
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7UUP
| SARS-CoV-2 Main Protease S144A (Mpro S144A) in Complex with Nirmatrelvir (PF-07321332) | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, CHLORIDE ION | 著者 | Westberg, M, Fernandez, D, Lin, M.Z. | 登録日 | 2022-04-28 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Sci Transl Med, 16, 2024
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8PK0
| human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7 | 分子名称: | 16S rRNA + pre-H68-71 segment, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Kummer, E, Nguyen, T.G, Ritter, C. | 登録日 | 2023-06-23 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Nat Commun, 14, 2023
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8RB4
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