PDB: 37819 件ウェブページステータス検索Chemie searchBIRD

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2R8H	Selectivity of Nucleoside Triphosphate Incorporation Opposite 1,N2-Propanodeoxyguanosine (PdG) by the Sulfolobus solfataricus DNA Polymerase Dpo4 Polymerase 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*DGP*DGP*DGP*DGP*DGP*DAP*DAP*DGP*DGP*DAP*DTP*DTP*DC)-3'), ... 著者 Wang, Y, Saleh, S, Marnette, L.J, Egli, M, Stone, M.P. 登録日 2007-09-10 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV Biochemistry, 47, 2008
2CVW	Structures of Yeast Ribonucleotide Reductase I 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... 著者 Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. 登録日 2005-06-14 公開日 2006-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation Proc.Natl.Acad.Sci.Usa, 103, 2006
6X0M	Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin 分子名称: DNA (167-MER), Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2 著者 Halic, M, Bilokapic, S. 登録日 2020-05-16 公開日 2020-09-16 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin. Nature, 585, 2020
8BVS	Cryo-EM structure of rat SLC22A6 bound to tenofovir 分子名称: CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ... 著者 Parker, J.L, Kato, T, Newstead, S. 登録日 2022-12-05 公開日 2023-07-19 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.61 Å) 主引用文献 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
8BVR	Cryo-EM structure of rat SLC22A6 in the apo state 分子名称: PHOSPHATE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) 著者 Parker, J.L, Kato, T, Newstead, S. 登録日 2022-12-05 公開日 2023-07-19 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.52 Å) 主引用文献 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
8BVT	Cryo-EM structure of rat SLC22A6 bound to probenecid 分子名称: 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody) 著者 Parker, J.L, Kato, T, Newstead, S. 登録日 2022-12-06 公開日 2023-07-19 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.94 Å) 主引用文献 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
8BW7	Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid 分子名称: 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ... 著者 Parker, J.L, Kato, T, Newstead, S. 登録日 2022-12-06 公開日 2023-07-19 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat.Struct.Mol.Biol., 30, 2023
8BXG	Structure of the K/H exchanger KefC. 分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE MONOPHOSPHATE, Glutathione-regulated potassium-efflux system protein KefC, ... 著者 Gulati, A, Drew, D. 登録日 2022-12-08 公開日 2023-12-20 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structure and mechanism of the K + /H + exchanger KefC. Nat Commun, 15, 2024
8BY2	Structure of the K+/H+ exchanger KefC with GSH. 分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE MONOPHOSPHATE, GLUTATHIONE, ... 著者 Gulati, A, Drew, D. 登録日 2022-12-11 公開日 2023-12-27 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structure and mechanism of the K + /H + exchanger KefC. Nat Commun, 15, 2024
2YFV	The heterotrimeric complex of Kluyveromyces lactis Scm3, Cse4 and H4 分子名称: HISTONE H3-LIKE CENTROMERIC PROTEIN CSE4, HISTONE H4, IODIDE ION, ... 著者 Cho, U.S, Harrison, S.C. 登録日 2011-04-08 公開日 2011-05-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Recognition of the Centromere-Specific Histone Cse4 by the Chaperone Scm3. Proc.Natl.Acad.Sci.USA, 108, 2011
6CGM	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free) 分子名称: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGL	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4) 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7) 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3SBT	Crystal structure of a Aar2-Prp8 complex 分子名称: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8, S-1,2-PROPANEDIOL, ... 著者 Weber, G, Santos, K.F, Holton, N, Wahl, M.C. 登録日 2011-06-06 公開日 2011-07-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
1MX7	Two homologous rat cellular retinol-binding proteins differ in local structure and flexibility 分子名称: CELLULAR RETINOL-BINDING PROTEIN I, APO 著者 Lu, J, Cistola, D.P, Li, E. 登録日 2002-10-01 公開日 2003-07-29 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Two Homologous Rat Cellular Retinol-binding Proteins Differ in Local Conformational Flexibility. J.Mol.Biol., 330, 2003
7JM9	Sheep Connexin-50 at 2.5 angstroms reoslution, Lipid Class 2 分子名称: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Gap junction alpha-8 protein 著者 Flores, J.A, Haddad, B.G, Dolan, K.A, Myers, J.A, Yoshioka, C.C, Copperman, J, Zuckerman, D.M, Reichow, S.L. 登録日 2020-07-31 公開日 2020-09-09 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 angstrom. Nat Commun, 11, 2020
6DQX	Actinobacillus ureae class Id ribonucleotide reductase alpha subunit 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 McBride, M.J, Palowitch, G.M, Boal, A.K. 登録日 2018-06-11 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis. Biochemistry, 58, 2019
4JK8	Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKF	Open and closed forms of T1791P+R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKE	Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKA	Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion 分子名称: CHLORIDE ION, COBALT (II) ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
8DHU	Crystal structure of LARP-DM15 from Drosophila melanogaster bound to m7GpppC 分子名称: La-related protein 1, MAGNESIUM ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate 著者 Nguyen, E, Berman, A.J. 登録日 2022-06-28 公開日 2024-01-17 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (2.295 Å) 主引用文献 Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution. Plos One, 19, 2024
4JKG	Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
6X0L	Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin 分子名称: DNA (167-MER), Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2 著者 Halic, M, Bilokapic, S. 登録日 2020-05-16 公開日 2020-09-16 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin. Nature, 585, 2020
8TU6	CryoEM structure of PI3Kalpha 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Valverde, R, Shi, H, Holliday, M. 登録日 2023-08-15 公開日 2023-11-15 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024

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