PDB: 243911 件ウェブページステータス検索Chemie searchBIRD

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6DF2	Improved anti-phosphotyrosine antibody 4G10-S5-4D5 Fab complexed with phosphotyrosine peptide 分子名称: Anti-phosphotyrosine antibody c310-4D5 heavy chain, Anti-phosphotyrosine antibody c310-4D5 light chain, LEU-PTR-LEU 著者 Mou, K, Leung, K, Wells, J.A. 登録日 2018-05-13 公開日 2018-11-28 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. J. Am. Chem. Soc., 140, 2018
7S0I	CRYSTAL STRUCTURE OF N1 NEURAMINIDASE FROM A/Michigan/45/2015(H1N1) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuraminidase, ... 著者 Zhu, X, Wilson, I.A. 登録日 2021-08-30 公開日 2021-12-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.892 Å) 主引用文献 A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model. Mbio, 12, 2021
7SP5	Crystal Structure of a Eukaryotic Phosphate Transporter 分子名称: PHOSPHATE ION, Phosphate transporter, nonyl beta-D-glucopyranoside 著者 Stroud, R.M, Pedersen, B.P, Kumar, H, Waight, A.B, Risenmay, A.J, Roe-Zurz, Z, Chau, B.H, Schlessinger, A, Bonomi, M, Harries, W, Sali, A, Johri, A.K, Finer-Moore, J. 登録日 2021-11-02 公開日 2021-11-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of a eukaryotic phosphate transporter. Nature, 496, 2013
7SHU	IgE-Fc in complex with omalizumab variant C02 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant epsilon, ... 著者 Pennington, L.F, Jardetzky, T.J, Kleinboelting, S. 登録日 2021-10-11 公開日 2021-12-15 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun, 12, 2021
7SI0	IgE-Fc in complex with 813 分子名称: 813 Variable fragment Heavy chain, 813 Variable fragment Light chain, IgE Fc, ... 著者 Pennington, L.F, Jardetzky, T.J, Kleinboelting, S. 登録日 2021-10-12 公開日 2021-12-15 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun, 12, 2021
6DIX	NFVFGT segment from Human Immunoglobulin Light-Chain Variable Domain, Residues 98-103, assembled as an amyloid fibril 分子名称: NFVFGT Immunoglobulin Light-Chain Variable Domain 著者 Brumshtein, B, Esswein, S.R, Sawaya, M.R, Eisenberg, D.S. 登録日 2018-05-23 公開日 2018-10-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. J. Biol. Chem., 293, 2018
7SHZ	IgE-Fc in complex with HAE 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Pennington, L.F, Jardetzky, T.J, Kleinboelting, S. 登録日 2021-10-11 公開日 2021-12-22 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun, 12, 2021
6DMG	A multiconformer ligand model of EK6 bound to ERK2 分子名称: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Hudson, B.M, van Zundert, G.C.P, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H. 登録日 2018-06-05 公開日 2018-12-19 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps. J. Med. Chem., 61, 2018
6DN3	CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1555 SPLIT RNA 分子名称: 7,8-dimethyl-2,4-dioxo-10-(3-phenylpropyl)-1,2,3,4-tetrahydrobenzo[g]pteridin-10-ium, CHLORIDE ION, MAGNESIUM ION, ... 著者 Vicens, Q, Mondragon, E, Reyes, F.E, Berman, J, Kaur, H, Kells, K, Wickens, P, Wilson, J, Gadwood, R, Schostarez, H, Suto, R.K, Coish, P, Blount, K.F, Batey, R.T. 登録日 2018-06-05 公開日 2018-09-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem. Biol., 13, 2018
7SPO	Crystal structure of the SARS-CoV-2 receptor binding domain in complex with VNAR 3B4 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... 著者 Shi, K, Aihara, H. 登録日 2021-11-02 公開日 2022-01-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography. Nat Commun, 12, 2021
9GSV	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4c 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-(2-phenylethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-16 公開日 2025-09-24 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
9GSW	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4d 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-(2-trimethylsilylethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-16 公開日 2025-09-24 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
6DOK	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 2 mM Mg2+ and 25 mM K+ for 120 s at 21 C (dataset 1) 分子名称: 1,2-ETHANEDIOL, 5'-R(*AP*CP*AP*U)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), 5'-R(P*CP*G)-3' portion of intact RNA (5'-R(*AP*CP*AP*UP*CP*G)-3'), ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
9GTT	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4l 分子名称: (2R,3R,4R,5S)-2-[2-(1-adamantyl)ethyl]-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-18 公開日 2025-10-01 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
6DPC	Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 12 mM Mn2+ and 200 mM K+ for 40 s at 21 C 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*AP*TP*GP*T)-3'), GLYCEROL, ... 著者 Samara, N.L, Yang, W. 登録日 2018-06-09 公開日 2018-08-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Cation trafficking propels RNA hydrolysis. Nat. Struct. Mol. Biol., 25, 2018
7SLY	Vanin-1 complexed with Compound 27 分子名称: (8-oxa-2-azaspiro[4.5]decan-2-yl)(2-{[(1S)-1-(pyrazin-2-yl)ethyl]amino}pyrimidin-5-yl)methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, Pantetheinase, ... 著者 Vajdos, F.F. 登録日 2021-10-25 公開日 2022-01-12 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J.Med.Chem., 65, 2022
8JL3	membrane proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL COENZYME *A, ... 著者 Yu, J, Ge, J.P, Xu, R.S. 登録日 2023-06-02 公開日 2024-05-22 最終更新日 2025-06-18 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Structure and mechanism of lysosome transmembrane acetylation by HGSNAT. Nat.Struct.Mol.Biol., 31, 2024
7SLX	Vanin-1 complexed with Compound 11 分子名称: (3R)-1-(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidine-5-carbonyl)piperidine-3-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Pantetheinase, ... 著者 Vajdos, F.F. 登録日 2021-10-25 公開日 2022-01-12 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J.Med.Chem., 65, 2022
7SLV	Vanin-1 complexed with Compound 3 分子名称: (8-oxa-2-azaspiro[4.5]decan-2-yl)(2-{[(pyrazin-2-yl)methyl]amino}pyrimidin-5-yl)methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, Pantetheinase, ... 著者 Vajdos, F.F. 登録日 2021-10-25 公開日 2022-01-12 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J.Med.Chem., 65, 2022
6DQT	Crystal structure of Haemophilus influenzae OppA complex with LGG 分子名称: ACETATE ION, LEU-GLY-GLY, Periplasmic oligopeptide-binding protein, ... 著者 Tanaka, K.J, Pinkett, H.W. 登録日 2018-06-11 公開日 2018-11-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Oligopeptide-binding protein from nontypeableHaemophilus influenzaehas ligand-specific sites to accommodate peptides and heme in the binding pocket. J. Biol. Chem., 294, 2019
9GTC	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4g 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-pentyl-piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-17 公開日 2025-10-01 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
9GTD	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4i 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(2-cyclohexylethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-17 公開日 2025-10-01 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
9GTN	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4k 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-18 公開日 2025-10-01 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
9GTL	Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with iminosugar compound 4j 分子名称: (2~{R},3~{R},4~{R},5~{S})-2-(hydroxymethyl)-2-(3-phenylpropyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Sulzenbacher, G, Roig-Zamboni, V, Moracci, M, Parenti, G, Py, S. 登録日 2024-09-18 公開日 2025-10-01 最終更新日 2025-10-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 C -Branched Iminosugars as Selective Pharmacological Chaperones of Lysosomal alpha-Glucosidase for the Treatment of Pompe Disease. J.Med.Chem., 68, 2025
8JL4	membrane proteins 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... 著者 Yu, J, Ge, J.P, Xu, R.S. 登録日 2023-06-02 公開日 2024-05-22 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 membrane proteins To Be Published

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