9B1Q
 
 | | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PYN1 inhibitor | | 分子名称: | (5P)-1-[(imidazolidin-1-yl)methyl]-5-(1H-indol-3-yl)-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ... | | 著者 | Geeraerts, Z, Yeh, S.-R. | | 登録日 | 2024-03-13 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.624 Å) | | 主引用文献 | Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
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9B17
 | | Crystal Structure of human Tryptophan 2,3-dioxygenase in complex with PAN1 inhibitor | | 分子名称: | (5P)-5-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-1,2,3-benzotriazole, PROTOPORPHYRIN IX CONTAINING FE, Tryptophan 2,3-dioxygenase, ... | | 著者 | Geeraerts, Z, Yeh, S.-R. | | 登録日 | 2024-03-13 | | 公開日 | 2024-08-21 | | 最終更新日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.
J.Med.Chem., 67, 2024
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9FAC
 | | Additional cryo-EM structure of cardiac amyloid AL59 - mixed polymorph | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal immunoglobulin light chains (LC) | | 著者 | Schulte, T, Speranzini, V, Chaves-Sanjuan, A, Milazzo, M, Ricagno, S. | | 登録日 | 2024-05-10 | | 公開日 | 2024-08-14 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis.
Nat Commun, 15, 2024
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8UP1
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8VDJ
 | | Crystal structure of SARS-CoV-2 3CL protease (3CLpro) as a covalent complex with EDP-235 | | 分子名称: | 3C-like proteinase nsp5, 4,6,7-trifluoro-N-{(2S)-1-[(3R,5'R)-5'-(iminomethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1'-yl]-4-methyl-1-oxopentan-2-yl}-N-methyl-1H-indole-2-carboxamide, THIOCYANATE ION | | 著者 | Cade, I.A, Rhodin, M.H.J. | | 登録日 | 2023-12-15 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo.
Nat Commun, 15, 2024
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8Y2T
 | | Crystal structure of 3C protease from coxsackievirus B3 | | 分子名称: | Protease 3C | | 著者 | Jiang, H.H, Zou, X.F, Zhang, J, Li, J. | | 登録日 | 2024-01-27 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of the 3C proteases from Coxsackievirus B3 and B4.
Acta Crystallogr.,Sect.F, 80, 2024
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8UTM
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8U5L
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8Y2U
 | | Crystal structure of 3C protease from coxsackievirus B4 | | 分子名称: | Protease 3C | | 著者 | Jiang, H.H, Lin, C, Zhang, J, Li, J. | | 登録日 | 2024-01-27 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal structures of the 3C proteases from Coxsackievirus B3 and B4.
Acta Crystallogr.,Sect.F, 80, 2024
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9FAB
 | | Additional cryo-EM structure of cardiac amyloid AL59 - bent polymorph | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal immunoglobulin light chains (LC) | | 著者 | Schulte, T, Speranzini, V, Chaves-Sanjuan, A, Milazzo, M, Ricagno, S. | | 登録日 | 2024-05-10 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Additional cryo-EM structure of cardiac amyloid AL59 - bent polymorph
To be published
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9CYS
 | | Toxin/immunity complex for a T6SS lipase effector from E. cloacae | | 分子名称: | Ankyrin repeat domain-containing protein, CITRIC ACID, GLYCEROL, ... | | 著者 | Cuthbert, B.J, Jensen, S.J, Goulding, C.W, Hayes, C.S. | | 登録日 | 2024-08-02 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Advanced glycation end-product (AGE) crosslinking activates a type 6 secretion system phospholipase effector protein
Nature Communications, 2024
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9CTH
 | | Preliminary map of the Prothrombin-prothrombinase complex on nano discs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated Factor V (FVa) heavy chain, Activated Factor V (FVa) light chain, ... | | 著者 | Stojanovski, B.M, Mohammed, B.M, Di Cera, E. | | 登録日 | 2024-07-25 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (6.47 Å) | | 主引用文献 | The Prothrombin-Prothrombinase Interaction.
Subcell Biochem, 104, 2024
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9EV6
 | | Corynebacterium glutamicum pyruvate:quinone oxidoreductase (PQO), C-terminal truncated construct | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, THIAMINE DIPHOSPHATE, ... | | 著者 | Da Silva Lameira, C, Muenssinger, S, Yang, L, Eikmanns, B.J, Bellinzoni, M. | | 登録日 | 2024-03-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.891 Å) | | 主引用文献 | Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features.
Febs J., 2024
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8QWV
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8QWU
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8QWW
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8WKY
 | | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25 | | 分子名称: | CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ... | | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | | 登録日 | 2023-09-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
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8WKZ
 | | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31 | | 分子名称: | CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ... | | 著者 | Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S. | | 登録日 | 2023-09-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
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9ATW
 | | Structure of biofilm-forming functional amyloid PSMa1 from Staphylococcus aureus | | 分子名称: | Phenol-soluble modulin alpha 1 peptide | | 著者 | Hansen, K.H, Byeon, C.H, Liu, Q, Drace, T, Boesen, T, Conway, J.F, Andreasen, M, Akbey, U. | | 登録日 | 2024-02-27 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-08-21 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of biofilm-forming functional amyloid PSM alpha 1 from Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9EV5
 | | Corynebacterium glutamicum CS176 pyruvate:quinone oxidoreductase (PQO) in complex with FAD and thiamine diphosphate-magnesium ion | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, THIAMINE DIPHOSPHATE, ... | | 著者 | Da Silva Lameira, C, Muenssinger, S, Yang, L, Eikmanns, B.J, Bellinzoni, M. | | 登録日 | 2024-03-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.863 Å) | | 主引用文献 | Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features.
Febs J., 2024
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9EV3
 | | Corynebacterium glutamicum pyruvate:quinone oxidoreductase (PQO) purified from bacteria grown in acetate minimal medium | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, THIAMINE DIPHOSPHATE, ... | | 著者 | Da Silva Lameira, C, Muenssinger, S, Yang, L, Eikmanns, B.J, Bellinzoni, M. | | 登録日 | 2024-03-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.219 Å) | | 主引用文献 | Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features.
Febs J., 2024
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9BPF
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9EV4
 | | Pyruvate:quinone oxidoreductase (PQO) from Corynebacterium glutamicum CS176 | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (Cytochrome), ... | | 著者 | Da Silva Lameira, C, Muenssinger, S, Yang, L, Eikmanns, B.J, Bellinzoni, M. | | 登録日 | 2024-03-28 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.474 Å) | | 主引用文献 | Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features.
Febs J., 2024
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9BOO
 | | Crystal structure of MERS-CoV Nsp5 in complex with PF-07817883 | | 分子名称: | 3C-like proteinase nsp5, N-(methoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-(trifluoromethyl)-L-prolinamide | | 著者 | Chen, P, Arutyunova, E, Lemieux, M.J. | | 登録日 | 2024-05-05 | | 公開日 | 2024-08-07 | | 最終更新日 | 2024-09-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M pro ) of SARS-CoV-2 and MERS-CoV.
Jacs Au, 4, 2024
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8K7U
 | | the alpha-galactosidase 5 with Cacl2 | | 分子名称: | Alpha-galactosidase | | 著者 | Li, Y.W, Ru, Y.X. | | 登録日 | 2023-07-27 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Activity-Based Meta proteomics Drives Discovery and Enzymological Characterization of Novel alpha-galactosidases in the Gut Microbiome
To Be Published
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