PDB: 307 件ウェブページステータス検索Chemie searchBIRD

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8AYP	NaK C-DI mutant with Rb+ and Ba2+ 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BARIUM ION, Potassium channel protein, ... 著者 Minniberger, S, Plested, A.J.R. 登録日 2022-09-02 公開日 2023-02-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel. J.Chem.Inf.Model., 63, 2023
6NFU	Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... 著者 Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. 登録日 2018-12-20 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
8K1V	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl 分子名称: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 著者 Chen, S, Lin, H. 登録日 2023-07-11 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.48 Å) 主引用文献 C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1Q	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl 分子名称: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 著者 Chen, S, Lin, H. 登録日 2023-07-11 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1Z	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl 分子名称: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 著者 Chen, S, Lin, H. 登録日 2023-07-11 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1J	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl 分子名称: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 著者 Chen, S, Lin, H. 登録日 2023-07-11 公開日 2024-04-17 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8AYQ	NaK C-DI mutant with Rb+ and Ca2+ 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 Minniberger, S, Plested, A.J.R. 登録日 2022-09-02 公開日 2023-02-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel. J.Chem.Inf.Model., 63, 2023
6NFV	Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... 著者 Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. 登録日 2018-12-20 公開日 2019-08-07 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
3UM7	Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1) 分子名称: POTASSIUM ION, Potassium channel subfamily K member 4 著者 Brohawn, S.G, MacKinnon, R. 登録日 2011-11-12 公開日 2012-02-08 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science, 335, 2012
1ZWI	Structure of mutant KcsA potassium channel 分子名称: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... 著者 Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Cortes, D.M, Roux, B, Perozo, E. 登録日 2005-06-03 公開日 2006-03-07 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
3UKM	Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1) 分子名称: POTASSIUM ION, Potassium channel subfamily K member 1, UNDECANE 著者 Long, S.B, Miller, A.N. 登録日 2011-11-09 公開日 2012-02-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal structure of the human two-pore domain potassium channel K2P1. Science, 335, 2012
7SQW	Structure of the KcsA-W67F mutant with the activation gate in the closed conformation 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Fragment, KcsA potassium channel, ... 著者 Cuello, L.G, Labro, A.J. 登録日 2021-11-07 公開日 2022-10-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels. Sci Adv, 8, 2022
4WFH	Human TRAAK K+ channel in a Tl+ bound nonconductive conformation 分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... 著者 Brohawn, S.G, MacKinnon, R. 登録日 2014-09-15 公開日 2014-12-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
4WFG	Human TRAAK K+ channel in a Tl+ bound conductive conformation 分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... 著者 Brohawn, S.G, MacKinnon, R. 登録日 2014-09-15 公開日 2014-12-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
4WFE	Human TRAAK K+ channel in a K+ bound conductive conformation 分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... 著者 Brohawn, S.G, MacKinnon, R. 登録日 2014-09-15 公開日 2014-12-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
4WFF	Human TRAAK K+ channel in a K+ bound nonconductive conformation 分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... 著者 Brohawn, S.G, MacKinnon, R. 登録日 2014-09-15 公開日 2014-12-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014
5VK6	Open conformation of KcsA non-inactivating E71A mutant 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... 著者 Cuello, L.G, Perozo, E. 登録日 2017-04-21 公開日 2017-12-06 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
5VKE	Open conformation of KcsA deep-inactivated 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... 著者 Cuello, L.G, Perozo, E, Cortes, D.M. 登録日 2017-04-21 公開日 2017-12-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
4XDK	Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine 分子名称: (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2014-12-19 公開日 2015-03-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
5VKH	Closed conformation of KcsA Y82A-F103A mutant 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ... 著者 Cuello, L.G, Perozo, E, Cortes, D.M. 登録日 2017-04-21 公開日 2017-12-06 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The gating cycle of a K+ channel at atomic resolution. Elife, 6, 2017
8THN	KcsA M96V mutant with Y78ester in High K+ 分子名称: KcsA Fab Heavy Chain, KcsA Fab Light Chain, POTASSIUM ION, ... 著者 Reddi, R, Valiyaveetil, F.I. 登録日 2023-07-17 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A facile approach for incorporating tyrosine esters to probe ion-binding sites and backbone hydrogen bonds. J.Biol.Chem., 300, 2023
8QZ1	Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) 分子名称: Isoform B of Potassium channel subfamily K member 10, Nanobody 58, POTASSIUM ION 著者 Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2023-10-26 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.588 Å) 主引用文献 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
8QZ3	Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ... 著者 Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2023-10-26 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
8QZ2	Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61) 分子名称: Nanobody 61, POTASSIUM ION, Potassium channel subfamily K member 10 著者 Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2023-10-26 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
8QZ4	Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76) 分子名称: BARIUM ION, CHOLESTEROL HEMISUCCINATE, Nanobody 76, ... 著者 Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2023-10-26 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024

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