PDB: 153 件ウェブページステータス検索Chemie searchBIRD

---

5UWI	Crystal Structure of HDAC5 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.143 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
7YPZ	Zafirlukast in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-08-05 公開日 2023-08-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
8HUG	F1 in complex with CRM1-Ran-RanBP1 分子名称: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-23 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 F1 in complex with CRM1-Ran-RanBP1 To Be Published
3WYG	Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex 分子名称: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... 著者 Koyama, M, Shirai, N, Matsuura, Y. 登録日 2014-08-26 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
5UWW	Crystal Structure of DEAF1 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1 分子名称: Deformed epidermal autoregulatory factor 1 homolog, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.152 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
6M60	Plumbagin in complex with CRM1#-Ran-RanBP1 分子名称: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Sun, Q, Lei, Y. 登録日 2020-03-12 公開日 2021-06-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
6XJU	Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.193 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6X2U	Crystal Structure of PKINES peptide bound to CRM1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
5XOJ	Crystal structure of Xpo1p-PKI-Nup42p-Gsp1p-GTP complex 分子名称: Exportin-1, GTP-binding nuclear protein, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Koyama, M, Shirai, N, Matsuura, Y. 登録日 2017-05-29 公開日 2017-08-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p Genes Cells, 22, 2017
4HB0	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
4GPT	Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-08-21 公開日 2012-09-05 最終更新日 2013-01-23 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
3WYF	Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex 分子名称: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... 著者 Koyama, M, Shirai, N, Matsuura, Y. 登録日 2014-08-26 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
5UWJ	Crystal Structure of FMRP NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.221 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWR	Crystal Structure of CDC7 NES Peptide (extended) in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, Cell division cycle 7-related protein kinase, Exportin-1, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWU	Crystal Structure of SMAD4 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
8HQ5	G6 in complex with CRM1-Ran-RanBP1 分子名称: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-13 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 F1 in complex with CRM1-Ran-RanBP1 To Be Published
5UWH	Crystal Structure of Paxillin NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWQ	Crystal Structure of CDC7 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Cell division cycle 7-related protein kinase, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.278 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... 著者 Fung, H.Y, Chook, Y.M. 登録日 2015-08-31 公開日 2015-09-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
4HAX	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Chook, Y.M. 登録日 2012-09-27 公開日 2013-01-09 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: CHLORIDE ION, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y, Chook, Y.M. 登録日 2015-08-30 公開日 2015-09-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.285 Å) 主引用文献 Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8HUF	B28 in complex with CRM1-Ran-RanBP1 分子名称: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-12-23 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 B28 in complex with CRM1-Ran-RanBP1 To Be Published
6X2R	Crystal Structure of the 4E-TNES peptide bound to CRM1 分子名称: Eukaryotic translation initiation factor 4E transporter, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.299 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
1QGR	STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH) 分子名称: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT) 著者 Cingolani, G, Petosa, C, Weis, K, Muller, C.W. 登録日 1999-05-04 公開日 1999-05-24 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of importin-beta bound to the IBB domain of importin-alpha. Nature, 399, 1999
5YSU	Plumbagin in complex with CRM1-RanM189D-RanBP1 分子名称: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, Exportin-1,Exportin-1, ... 著者 Sun, Q, Zhang, Y. 登録日 2017-11-15 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 RanL182A in complex with RanBP1-CRM1 To Be Published

<1234567>