PDB: 35 件ウェブページステータス検索Chemie searchBIRD

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5SVQ	Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, P2X purinoceptor 3, ... 著者 Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. 登録日 2016-08-07 公開日 2016-10-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
5SVM	Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the desensitized state 分子名称: 1,2-ETHANEDIOL, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Mansoor, S.E, Lu, W, Oosterheert, W, Shekhar, M, Tajkhorshid, E, Gouaux, E. 登録日 2016-08-06 公開日 2016-09-28 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.093 Å) 主引用文献 X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature, 538, 2016
5U1U	Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{(1R)-1-[N''-cyano-N'-(quinolin-5-yl)carbamimidamido]-2,2-dimethylpropyl}-2-(3,4-dimethoxyphenyl)acetamide, P2X purinoceptor 著者 Karasawa, A, Kawate, T. 登録日 2016-11-29 公開日 2017-01-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.604 Å) 主引用文献 Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife, 5, 2016
5U1Y	Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist GW791343 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, N~2~-(3,4-difluorophenyl)-N-{2-methyl-5-[(piperazin-1-yl)methyl]phenyl}glycinamide, P2X purinoceptor 著者 Karasawa, A, Kawate, T. 登録日 2016-11-29 公開日 2017-01-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife, 5, 2016
5U1X	Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist JNJ47965567 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide, ... 著者 Karasawa, A, Kawate, T. 登録日 2016-11-29 公開日 2017-01-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.201 Å) 主引用文献 Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife, 5, 2016
6U9V	Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo, closed state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mansoor, S.E, McCarthy, A.E. 登録日 2019-09-09 公開日 2019-10-23 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Full-Length P2X7Structures Reveal How Palmitoylation Prevents Channel Desensitization. Cell, 179, 2019
6U9W	Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Mansoor, S.E, McCarthy, A.E. 登録日 2019-09-09 公開日 2019-10-23 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Full-Length P2X7Structures Reveal How Palmitoylation Prevents Channel Desensitization. Cell, 179, 2019
8TR5	Cryo-EM structure of the rat P2X7 receptor in the apo closed state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... 著者 Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. 登録日 2023-08-09 公開日 2024-08-14 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (2.53 Å) 主引用文献 High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
8TRJ	Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... 著者 Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. 登録日 2023-08-09 公開日 2024-08-14 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024
8V4S	Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, P2X purinoceptor 7, ... 著者 Oken, A.C, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Glasfeld, A, Mansoor, S.E. 登録日 2023-11-29 公開日 2024-08-14 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket. Nat Commun, 15, 2024

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