PDB: 48369 件ウェブページステータス検索Chemie searchBIRD

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7NMZ	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448 分子名称: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Obsil, T, Obsilova, V. 登録日 2021-02-23 公開日 2021-07-21 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
3AXY	Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 分子名称: 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 著者 Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. 登録日 2011-04-19 公開日 2011-08-03 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011
6EWW	Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif 分子名称: 14-3-3 protein zeta/delta, ARG-LYS-LEU-SEP-LEU-GLN-GLU-ARG 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2017-11-06 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.679 Å) 主引用文献 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Kalabova, D, Obsil, T, Obsilova, V. 登録日 2019-07-16 公開日 2020-01-22 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.753 Å) 主引用文献 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020
6FEL	Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511 分子名称: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2018-01-02 公開日 2018-01-10 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
8DS6	Structure of the PEAK3 pseudokinase homodimer 分子名称: Protein PEAK3 著者 Torosyan, H, Paul, M, Jura, N, Verba, K.A. 登録日 2022-07-21 公開日 2023-06-28 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
7ZIT	14-3-3 in complex with SARS-COV2 N phospho-peptide 分子名称: 14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ... 著者 Eisenreichova, A, Boura, E. 登録日 2022-04-08 公開日 2022-10-26 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins. J.Struct.Biol., 214, 2022
6J14	Complex structure of GY-14 and PD-1 分子名称: GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1 著者 Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. 登録日 2018-12-27 公開日 2019-11-06 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy. Iscience, 14, 2019
8DGO	Growth Factor Receptor-Bound Protein 2 (Grb2) bound to phosphorylated PEAK3 (pY24) peptide 分子名称: Growth factor receptor bound protein 2, Phosphorylated PEAK3 (pY24) peptide 著者 Roy, M.J, Hardy, J.M, Lucet, I.S. 登録日 2022-06-24 公開日 2023-06-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
8R2I	Cryo-EM Structure of native Photosystem II assembly intermediate from Chlamydomonas reinhardtii 分子名称: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2,3-DIMETHYL-5-(3,7,11,15,19,23,27,31,35-NONAMETHYL-2,6,10,14,18,22,26,30,34-HEXATRIACONTANONAENYL-2,5-CYCLOHEXADIENE-1,4-DIONE-2,3-DIMETHYL-5-SOLANESYL-1,4-BENZOQUINONE, ... 著者 Fadeeva, M, Klaiman, D, Kandiah, E, Nelson, N. 登録日 2023-11-06 公開日 2024-01-31 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structure of native photosystem II assembly intermediate from Chlamydomonas reinhardtii . Front Plant Sci, 14, 2023
8C3C	14-3-3 sigma with Pin1 binding site pS72 and bound Fusicoccin A 分子名称: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... 著者 Verhoef, C.J, Cossar, P. 登録日 2022-12-23 公開日 2023-06-14 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chem Sci, 14, 2023
2C63	14-3-3 Protein Eta (Human) Complexed to Peptide 分子名称: 14-3-3 PROTEIN ETA, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS 著者 Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A. 登録日 2005-11-07 公開日 2005-11-21 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2BQ0	14-3-3 Protein Beta (Human) 分子名称: 14-3-3 BETA/ALPHA 著者 Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. 登録日 2005-04-26 公開日 2005-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C3Z	14-3-3sigma bound to strep-tagged PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen receptor, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
7BGQ	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1019 分子名称: 14-3-3 protein sigma, 2-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGR	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1016 分子名称: 14-3-3 protein sigma, 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGV	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1012 分子名称: 14-3-3 protein sigma, 3-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.683 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDP	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1017 分子名称: 14-3-3 protein sigma, 2-chloranyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1011 分子名称: 14-3-3 protein sigma, 4-(2-phenylimidazol-1-yl)naphthalene-1-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDT	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1009 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDY	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068B 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-[2-(5-bromanyl-2-fluoranyl-phenyl)imidazol-1-yl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BFW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068A 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-05 公開日 2021-06-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8C2D	14-3-3 in complex with Pyrin pS208 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, Pyrin pS208 peptide 著者 Lau, R, Ottmann, C, Hann, M. 登録日 2022-12-22 公開日 2023-07-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure and ligandability of the 14-3-3/pyrin interface. Biochem.Biophys.Res.Commun., 651, 2023
7BJL	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-142 分子名称: 14-3-3 protein sigma, 3-[(3~{S})-3-methoxypiperidin-1-yl]-4-nitro-benzaldehyde, Transcription factor p65 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-06-09 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021

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