PDB: 6519 件ウェブページステータス検索Chemie searchBIRD

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6A83	Crystal structure of the C-terminal periplasmic domain of EcEptC from Escherichia coli complex with Zn 分子名称: Phosphoethanolamine transferase EptC, SODIUM ION, ZINC ION 著者 Zhao, Y.Q, Gu, Y.J, Cheng, W. 登録日 2018-07-06 公開日 2018-12-26 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Structural and mechanistic insights into polymyxin resistance mediated by EptC originating from Escherichia coli. FEBS J., 286, 2019
5SOF	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z373768900 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SOE	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z1429867185 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 4-methoxy-1H-indole, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNJ	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z906021418 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-chloro-2-(propan-2-yl)pyrimidine-4-carboxamide, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SO0	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z24758179 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNK	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z2856434941 分子名称: (2S)-1-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}propan-2-ol, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SOD	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z1730522163 分子名称: 1-[(2R)-8-fluoro-2-methyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethan-1-one, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNX	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z1267881672 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-(6-methylpyridin-2-yl)-L-prolinamide, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNI	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z285782452 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-methyl-2-(methylsulfonyl)aniline, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SOB	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z2204875953 分子名称: (3P)-3-(2H-1,3-benzodioxol-5-yl)-1H-pyrazole, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNW	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z730649594 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-[2-(4-hydroxyphenyl)ethyl]pyridine-2-carboxamide, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNE	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z192955056 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SOA	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z1613492358 分子名称: (2R)-4-(1H-pyrazol-1-yl)butan-2-ol, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNU	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z2856434770 分子名称: 1-(3-chlorophenyl)-N-methylmethanamine, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SO8	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z85895198 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, N-(4-fluorobenzoyl)-N-methylglycine, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SN6	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z2856434942 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SNN	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z1954800564 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-methoxy-1,3-benzothiazol-2-amine, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SO5	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with JKH93B 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SO1	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z30620520 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
5SOH	PanDDA analysis group deposition -- Crystal Structure of Pseudomonas Aeruginosa FabF-C164Q mutant protein in complex with Z31432226 分子名称: (azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Brenk, R, Georgiou, C. 登録日 2022-05-30 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 PanDDA analysis group deposition Chemrxiv, 2023
2ZCO	Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus 分子名称: Dehydrosqualene synthase 著者 Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E. 登録日 2007-11-11 公開日 2008-03-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science, 319, 2008
1J3J	Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... 著者 Yuvaniyama, J, Chitnumsub, P, Kamchonwongpaisan, S, Vanichtanankul, J, Sirawaraporn, W, Taylor, P, Walkinshaw, M, Yuthavong, Y. 登録日 2003-02-03 公開日 2003-05-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insights into antifolate resistance from malarial DHFR-TS structures. NAT.STRUCT.BIOL., 10, 2003
4GEV	E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, Thymidylate synthase 著者 Newby, Z, Lee, T.T, Finer-Moore, J, Stroud, R.M. 登録日 2012-08-02 公開日 2012-08-29 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J.Am.Chem.Soc., 134, 2012
6AEF	PapA2 acyl transferase 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Trehalose-2-sulfate acyltransferase PapA2, ... 著者 Chaudhary, S, Rao, V, Panchal, V. 登録日 2018-08-04 公開日 2019-06-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains. Faseb Bioadv, 1, 2019
3IJZ	Lactobacillus casei Thymidylate Synthase ternary complex with dUMP and Pthalimidic derivative 15C 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(4-acetylphenyl)-4-methyl-1H-isoindole-1,3(2H)-dione, Thymidylate synthase 著者 Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. 登録日 2009-08-05 公開日 2010-08-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54, 2011

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