PDB: 82686 件ウェブページステータス検索Chemie searchBIRD

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7TYP	TEAD2 bound to GNE-7883 分子名称: (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4 著者 Noland, C.L, Fong, R. 登録日 2022-02-14 公開日 2023-05-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers To Be Published
5DOV	Crystal structure of JamJ enoyl reductase (apo form) 分子名称: GLYCEROL, JamJ 著者 Khare, D, Smith, J.L. 登録日 2015-09-11 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
1A5P	C[40,95]A VARIANT OF BOVINE PANCREATIC RIBONUCLEASE A 分子名称: RIBONUCLEASE A, SULFATE ION 著者 Pearson, M.A, Karplus, P.A, Dodge, R.W, Laity, J.H, Scheraga, H.A. 登録日 1998-02-17 公開日 1998-05-27 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structures of two mutants that have implications for the folding of bovine pancreatic ribonuclease A. Protein Sci., 7, 1998
5DP1	Crystal structure of CurK enoyl reductase 分子名称: CurK, GLYCEROL, PHOSPHATE ION 著者 Khare, D, Smith, J.L. 登録日 2015-09-12 公開日 2015-11-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure, 23, 2015
2DE9	Crystal structure of porcine pancreatic elastase complexed with Tris after soaking a tris-free solution 分子名称: Elastase-1, SULFATE ION 著者 Kinoshita, T, Tada, T. 登録日 2006-02-09 公開日 2006-07-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase. Acta Crystallogr.,Sect.F, 62, 2006
7SV8	Carbonic Anhydrase IX-mimic Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, N-(2-{[(naphthalen-2-yl)methyl][2-(4-sulfamoylphenyl)ethyl]amino}-2-oxoethyl)-N-(2-phenylethyl)-beta-alanine, ... 著者 Combs, J.E, McKenna, R. 登録日 2021-11-18 公開日 2022-04-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.388 Å) 主引用文献 The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. J Enzyme Inhib Med Chem, 37, 2022
7SV1	Carbonic Anhydrase IX-mimic Complexed with 3-((2-((Naphthalen-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, N~2~-(3-aminopropyl)-N-[(4-fluorophenyl)methyl]-N~2~-(2-phenylethyl)-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide, ... 著者 Combs, J.E, McKenna, R. 登録日 2021-11-18 公開日 2022-04-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. J Enzyme Inhib Med Chem, 37, 2022
5CBS	Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution 分子名称: (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2015-07-01 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. J.Med.Chem., 59, 2016
6SMY	Crystal structure of SLA Reductase YihU from E. Coli with NADH and product DHPS 分子名称: (2~{S})-2,3-bis(oxidanyl)propane-1-sulfonic acid, 3-sulfolactaldehyde reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Sharma, M, Davies, G.J. 登録日 2019-08-23 公開日 2020-08-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Dynamic Structural Changes Accompany the Production of Dihydroxypropanesulfonate by Sulfolactaldehyde Reductase Acs Catalysis, 2020
8WFU	Crystal structure of beta-glucosidase from Thermoanaerobacterium saccharolyticum (Data 2) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase, SODIUM ION 著者 Nam, K.H. 登録日 2023-09-20 公開日 2023-10-04 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of beta-Glucosidase. Molecules, 28, 2023
8WFW	Crystal structure of beta-glucosidase from Thermoanaerobacterium saccharolyticum (Data 4) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase, SODIUM ION 著者 Nam, K.H. 登録日 2023-09-20 公開日 2023-10-04 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of beta-Glucosidase. Molecules, 28, 2023
8WFV	Crystal structure of beta-glucosidase from Thermoanaerobacterium saccharolyticum (Data 3) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucosidase, SODIUM ION 著者 Nam, K.H. 登録日 2023-09-20 公開日 2023-10-04 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Conformational Change of the L3 Loop Affects the Structural Changes in the Substrate Binding Pocket Entrance of beta-Glucosidase. Molecules, 28, 2023
4IO0	Crystal structure of F128A mutant of an epoxide hydrolase from Bacillus megaterium complexed with its product (R)-3-[1]naphthyloxy-propane-1,2-diol 分子名称: (2R)-3-(naphthalen-1-yloxy)propane-1,2-diol, SULFATE ION, Soluble epoxide hydrolase 著者 Kong, X.D, Zhou, J.H, Xu, J.H. 登録日 2013-01-07 公開日 2014-02-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc.Natl.Acad.Sci.USA, 111, 2014
1HMC	THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR 分子名称: HUMAN MACROPHAGE COLONY STIMULATING FACTOR 著者 Bohm, A, Pandit, J, Jancarik, J, Halenbeck, R, Koths, K, Kim, S.-H. 登録日 1993-12-22 公開日 1994-04-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Science, 258, 1992
7ELL	In situ structure of capping enzyme lambda2, penetration protein mu1 of mammalian reovirus capsid asymmetric unit. 分子名称: MYRISTIC ACID, Mu1, mRNA (guanine-N(7)-)-methyltransferase 著者 Zhou, Z.H, Pan, M. 登録日 2021-04-12 公開日 2021-10-20 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins. Nat Commun, 12, 2021
7ELH	In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state 分子名称: Lambda 1, Minor core protein mu2, PHOSPHATE ION, ... 著者 Zhou, Z.H, Pan, M. 登録日 2021-04-11 公開日 2021-10-20 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins. Nat Commun, 12, 2021
6UVM	Cocrystal of BRD4(D1) with a methyl carbamate thiazepane inhibitor 分子名称: 1,2-ETHANEDIOL, 1-[(7S)-7-(thiophen-2-yl)-6,7-dihydro-1,4-thiazepin-4(5H)-yl]ethan-1-one, Bromodomain-containing protein 4 著者 Johnson, J.A, Pomerantz, W.C.K. 登録日 2019-11-03 公開日 2020-01-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains. Acs Med.Chem.Lett., 10, 2019
7EQC	Crystal structure of the mini-centralspindlin complex 分子名称: CYtoKinesis defect, Kinesin-like protein 著者 Chen, Z, Pan, H. 登録日 2021-05-01 公開日 2022-04-13 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mechanistic insights into central spindle assembly mediated by the centralspindlin complex. Proc.Natl.Acad.Sci.USA, 118, 2021
7EQB	Crystal structure of the dimerization domain of ZEN-4 分子名称: Kinesin-like protein, SULFATE ION 著者 Chen, Z, Pan, H. 登録日 2021-05-01 公開日 2022-04-13 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 Mechanistic insights into central spindle assembly mediated by the centralspindlin complex. Proc.Natl.Acad.Sci.USA, 118, 2021
5EF8	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Hdac6 protein, ... 著者 Hai, Y, Christianson, D.W. 登録日 2015-10-23 公開日 2016-07-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat.Chem.Biol., 12, 2016
4ZZ6	Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleotide, cytidine triphosphate at 2.0A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-05-22 公開日 2015-06-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate. Biochem Biophys Rep, 4, 2015
5CSO	Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleoside, cytidine at 1.78 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, GLYCEROL, ... 著者 Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate. Biochem Biophys Rep, 4, 2015
5CST	Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a nucleotide, cytidine diphosphate at 1.78 A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Yamin, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. 登録日 2015-07-23 公開日 2015-08-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate. Biochem Biophys Rep, 4, 2015
6MKM	Crystallographic solvent mapping analysis of DMSO/Tris bound to APE1 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, ... 著者 Georgiadis, M.M, He, H, Chen, Q. 登録日 2018-09-25 公開日 2019-01-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.673 Å) 主引用文献 Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J. Med. Chem., 62, 2019
4HZN	The Structure of the Bifunctional Acetyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double Hot Dog Fold 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifunctional Methylmalonyl-CoA:ACP Acyltransferase/Decarboxylase, GLYCEROL, ... 著者 Lohman, J.R, Bingman, C.A, Phillips Jr, G.N, Shen, B, Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2012-11-15 公開日 2013-01-30 最終更新日 2013-02-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold. Biochemistry, 52, 2013

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