PDB: 82129 件ウェブページステータス検索Chemie searchBIRD

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8F85	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851 分子名称: 3-{2-[3-({(6M)-2,4-diamino-6-[2-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM851 To be published
8F84	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787 分子名称: 3-[2-(3-{[2,4-diamino-6-(4-hydroxybutyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787 To be published
8F83	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846 分子名称: 3-{2-[3-({2,4-diamino-6-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, Dihydrofolate reductase, IMIDAZOLE, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846 To be published
8F82	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-{2-[3-({(6M)-2,4-diamino-6-[3-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, BROMIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM845 To be published
8F81	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 分子名称: 3-(2-{3-[(2,4-diamino-6-pentylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM777 To be published
8F80	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 分子名称: 1,2-ETHANEDIOL, 3-[2-(3-{[2,4-diamino-6-(4-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-11-21 公開日 2023-12-13 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 To be published
8F7Z	VRC34.01_mm28 bound to fusion peptide 分子名称: HIV-1 Env Fusion Peptide, VRC34_m228 Light Chain, VRC34_mm28 Heavy Chain 著者 Olia, A.S, Kwong, P.D. 登録日 2022-11-21 公開日 2023-11-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site. Nat Commun, 14, 2023
8F7V	Macrocyclic plasmin inhibitor 分子名称: (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(benzenesulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, GLYCEROL, Plasminogen, ... 著者 Guojie, W. 登録日 2022-11-20 公開日 2023-02-08 最終更新日 2023-06-21 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Synthesis and structural characterization of new macrocyclicplasmin inhibitors Chemmedchem, 2023
8F7U	Macrocyclic Plasmin Inhibitor 分子名称: (5S,8R,18S,21R)-N-{[4-(aminomethyl)phenyl]methyl}-21-[(benzenesulfonyl)amino]-3,11,20-trioxo-2,5,8,12,19-pentaazatetracyclo[21.2.2.2~5,8~.2~13,16~]hentriaconta-1(25),13,15,23,26,28-hexaene-18-carboxamide, Activation peptide, GLYCEROL, ... 著者 Guojie, W. 登録日 2022-11-20 公開日 2023-02-08 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Synthesis and structural characterization of new macrocyclicplasmin inhibitors Chemmedchem, 2023
8F7P	BRAF kinase in complex with LXH254 (naporafenib) 分子名称: N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide, Serine/threonine-protein kinase B-raf 著者 Tkacik, E, Li, K, Gonzalez Del-Pino, G, Eck, M.J. 登録日 2022-11-20 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib. J.Biol.Chem., 299, 2023
8F7O	BRAF kinase in complex with TAK580 (tovorafenib) 分子名称: 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide, Serine/threonine-protein kinase B-raf 著者 Tkacik, E, Li, K, Gonzalez Del-Pino, G, Eck, M.J. 登録日 2022-11-20 公開日 2023-04-12 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3.54 Å) 主引用文献 Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib. J.Biol.Chem., 299, 2023
8F7N	Crystal structure of chemoreceptor McpZ ligand sensing domain 分子名称: Methyl-accepting chemotaxis protein, YTTERBIUM (III) ION 著者 Salar, S, Schubot, F.D. 登録日 2022-11-19 公開日 2023-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The structural analysis of the periplasmic domain of Sinorhizobium meliloti chemoreceptor McpZ reveals a novel fold and suggests a complex mechanism of transmembrane signaling. Proteins, 91, 2023
8F7K	Thermoplasma acidophilum 20S proteasome - wild type bound to ZYA 分子名称: N-[(benzyloxy)carbonyl]-L-tyrosyl-D-alanine, Proteasome subunit alpha, Proteasome subunit beta 著者 Chuah, J, Smith, D. 登録日 2022-11-18 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (1.94 Å) 主引用文献 High resolution structures define divergent and convergent mechanisms of archaeal proteasome activation. Commun Biol, 6, 2023
8F7I	The condensation domain of surfactin A synthetase C variant 18b in space group P43212 分子名称: GLYCEROL, Surfactin synthetase 著者 Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. 登録日 2022-11-18 公開日 2023-11-22 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024
8F7H	The condensation domain of surfactin A synthetase C variant 18b in space group P212121 分子名称: GLYCEROL, Surfactin synthetase 著者 Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, M. 登録日 2022-11-18 公開日 2023-11-22 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024
8F7G	The condensation domain of surfactin A synthetase C in space group P212121 分子名称: GLYCEROL, Surfactin synthetase 著者 Frota, N.F, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, T.M. 登録日 2022-11-18 公開日 2023-11-22 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024
8F7F	The condensation domain of surfactin A synthetase C in space group P43212 分子名称: GLYCEROL, Surfactin synthetase 著者 Frota, N, Pistofidis, A, Folger, I.B, Hilvert, D, Schmeing, T.M. 登録日 2022-11-18 公開日 2023-11-22 最終更新日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 High-throughput reprogramming of an NRPS condensation domain. Nat.Chem.Biol., 20, 2024
8F7C	Cryo-EM structure of human pannexin 2 分子名称: Pannexin-2, Soluble cytochrome b562 fusion 著者 He, Z, Yuan, P. 登録日 2022-11-18 公開日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Structural and functional analysis of human pannexin 2 channel. Nat Commun, 14, 2023
8F76	Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Billesboelle, C.B, Manglik, A. 登録日 2022-11-18 公開日 2023-03-22 最終更新日 2023-04-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of odorant recognition by a human odorant receptor. Nature, 615, 2023
8F70	Identification of an Immunodominant region on a Group A Streptococcus T-antigen Reveals Temperature-Dependent Motion in Pili 分子名称: CALCIUM ION, T18.1 Major pilin backbone protein T-antigen,Major pilin backbone protein T-antigen 著者 Young, P.G, Moreland, N.J. 登録日 2022-11-17 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili. Virulence, 14, 2023
8F6V	Crystal Structure of Nanobody VHH108 Bound to Its Antigen PA14 Cif 分子名称: CFTR inhibitory factor, Nanobody VHH108 著者 Simard, A.R, Madden, D.R. 登録日 2022-11-17 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif To Be Published
8F6U	Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif 分子名称: CFTR inhibitory factor, Nanobody VHH113 著者 Simard, A.R, Taher, N.M, Mishra, A.K, Madden, D.R. 登録日 2022-11-17 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of Nanobody VHH113 Bound to Its Antigen PA14 Cif To Be Published
8F6P	Rat Cardiac Sodium Channel with Ranolazine Bound 分子名称: (R)-ranolazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lenaeus, M.J, Tonggu, L. 登録日 2022-11-16 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Basis for Inhibition of the Cardiac Sodium Channel by the Atypical Antiarrhythmic Drug Ranolazine To Be Published
8F6O	anti-BTLA monoclonal antibody h22B3 in complex with BTLA 分子名称: B- and T-lymphocyte attenuator, h22B3 Fab heavy chain, h22B3 Fab light chain 著者 Hendle, J, Atwell, S, Lieu, R, Hickey, M, Weichert, K. 登録日 2022-11-16 公開日 2023-05-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA. Structure, 31, 2023
8F6N	Dihydropyrimidine Dehydrogenase (DPD) C671S Mutant Soaked with Thymine Quasi-Anaerobically 分子名称: Dihydropyrimidine dehydrogenase [NADP(+)], FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Kaley, N, Smith, M, Forouzesh, D, Liu, D, Moran, G. 登録日 2022-11-16 公開日 2023-02-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mammalian dihydropyrimidine dehydrogenase: Added mechanistic details from transient-state analysis of charge transfer complexes. Arch.Biochem.Biophys., 736, 2023

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