8F83

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846

Summary for 8F83

• Entry DOI: 10.2210/pdb8f83/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-{2-[3-({2,4-diamino-6-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid, ... (5 entities in total)
• Functional Keywords: ssgcid, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Mycobacterium ulcerans
• Total number of polymer chains: 1
• Total formula weight: 20382.59

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-21, release date: 2023-12-13, Last modification date: 2024-06-19)

• Primary citation: Seibold, S.,Battaile, K.P.,Lovell, S.,Staker, B.L.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM846; To be published,

Experimental method

X-RAY DIFFRACTION (1.32 Å)