3TVD
 
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4HKC
 
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3LNQ
 
 | Structure of Aristaless homeodomain in complex with DNA | 分子名称: | 5'-D(*CP*CP*CP*TP*AP*AP*TP*TP*AP*AP*AP*CP*CP*C)-3', 5'-D(*GP*GP*GP*TP*TP*TP*AP*AP*TP*TP*AP*GP*GP*G)-3', ACETATE ION, ... | 著者 | Takamura, Y, Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. | 登録日 | 2010-02-02 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
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1YWT
 
 | Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) | 著者 | Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. | 登録日 | 2005-02-18 | 公開日 | 2005-03-01 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
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3LQ5
 
 | Structure of CDK9/CyclinT in complex with S-CR8 | 分子名称: | (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1 | 著者 | Hole, A.J, Endicott, J.A, Baumli, S. | 登録日 | 2010-02-08 | 公開日 | 2011-01-19 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells Genes Cancer, 1, 2010
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1MD4
 
 | A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase | 著者 | Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W. | 登録日 | 2002-08-06 | 公開日 | 2002-08-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1 J.Biol.Chem., 278, 2003
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7ZKE
 
 | Mot1:TBP:DNA - pre-hydrolysis state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ... | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-04-12 | 公開日 | 2023-04-26 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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6HG9
 
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7Z8S
 
 | Mot1:TBP:DNA - post hydrolysis state | 分子名称: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-03-18 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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7Z7N
 
 | Mot1E1434Q:TBP:DNA - substrate recognition state | 分子名称: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-03-16 | 公開日 | 2023-03-29 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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7ZB5
 
 | Mot1(1-1836):TBP:DNA - post-hydrolysis complex dimer | 分子名称: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | 著者 | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | 登録日 | 2022-03-23 | 公開日 | 2023-04-05 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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1MD3
 
 | A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase | 著者 | Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W. | 登録日 | 2002-08-06 | 公開日 | 2002-08-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1 J.Biol.Chem., 278, 2003
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5CFU
 
 | Crystal Structure of ANT(2")-Ia in complex with adenylyl-2"-tobramycin | 分子名称: | 1,4-BUTANEDIOL, Aminoglycoside Nucleotidyltransferase (2")-Ia, MANGANESE (II) ION, ... | 著者 | Rodionov, D, Bassenden, A.V, Berghuis, A.M. | 登録日 | 2015-07-08 | 公開日 | 2016-07-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Revisiting the Catalytic Cycle and Kinetic Mechanism of AminoglycosideO-Nucleotidyltransferase(2′′): A Structural and Kinetic Study. Acs Chem.Biol., 2020
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2CCI
 
 | Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ... | 著者 | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | 登録日 | 2006-01-16 | 公開日 | 2006-05-03 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J. Biol. Chem., 281, 2006
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1JY0
 
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2UUE
 
 | REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors | 分子名称: | 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID, 4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE, CELL DIVISION PROTEIN KINASE 2, ... | 著者 | Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. | 登録日 | 2007-03-02 | 公開日 | 2007-03-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
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2PF4
 
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4EON
 
 | Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOJ
 
 | Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOK
 
 | Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102 | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2, MONOTHIOGLYCEROL, ... | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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4EOS
 
 | Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306 | 分子名称: | (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D. | 登録日 | 2012-04-14 | 公開日 | 2013-02-06 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity. Chem.Biol., 19, 2012
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2F2C
 
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8SG2
 
 | BIVALENT INTERACTIONS OF PIN1 WITH THE C-TERMINAL TAIL OF PKC | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Protein kinase C beta type | 著者 | Dixit, K, Yang, Y, Chen, X.R, Igumenova, T.I. | 登録日 | 2023-04-11 | 公開日 | 2024-05-08 | 最終更新日 | 2024-11-20 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation. Elife, 13, 2024
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2CCH
 
 | The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ... | 著者 | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | 登録日 | 2006-01-16 | 公開日 | 2006-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition J.Biol.Chem., 281, 2006
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3QZT
 
 | Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II | 分子名称: | GLYCEROL, Histone H4, Nucleosome-remodeling factor subunit BPTF | 著者 | Li, H, Ruthenburg, A.J, Patel, D.J. | 登録日 | 2011-03-07 | 公開日 | 2011-06-01 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell(Cambridge,Mass.), 145, 2011
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