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3TVD
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BU of 3tvd by Molmil
Crystal Structure of Mouse RhoA-GTP complex
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA
著者Swaminathan, K, Pal, K, Jobichen, C.
登録日2011-09-20
公開日2012-10-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.989 Å)
主引用文献Crystal structure of mouse RhoA:GTPgammaS complex in a centered lattice.
J.Struct.Funct.Genom., 13, 2012
4HKC
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BU of 4hkc by Molmil
14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
分子名称: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide
著者Bonet, R, Campbell, I.D.
登録日2012-10-15
公開日2013-06-26
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Characterization of 14-3-3-zeta Interactions with integrin tails
J.Mol.Biol., 425, 2013
3LNQ
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BU of 3lnq by Molmil
Structure of Aristaless homeodomain in complex with DNA
分子名称: 5'-D(*CP*CP*CP*TP*AP*AP*TP*TP*AP*AP*AP*CP*CP*C)-3', 5'-D(*GP*GP*GP*TP*TP*TP*AP*AP*TP*TP*AP*GP*GP*G)-3', ACETATE ION, ...
著者Takamura, Y, Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M.
登録日2010-02-02
公開日2010-04-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless
Embo J., 29, 2010
1YWT
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BU of 1ywt by Molmil
Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1)
著者Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B.
登録日2005-02-18
公開日2005-03-01
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
3LQ5
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BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
分子名称: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
著者Hole, A.J, Endicott, J.A, Baumli, S.
登録日2010-02-08
公開日2011-01-19
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010
1MD4
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BU of 1md4 by Molmil
A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase
著者Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W.
登録日2002-08-06
公開日2002-08-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1
J.Biol.Chem., 278, 2003
7ZKE
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BU of 7zke by Molmil
Mot1:TBP:DNA - pre-hydrolysis state
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ...
著者Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P.
登録日2022-04-12
公開日2023-04-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
Nat.Struct.Mol.Biol., 30, 2023
6HG9
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BU of 6hg9 by Molmil
Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II
分子名称: Interleukin-17 receptor C, Interleukin-17F
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-23
公開日2020-03-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
7Z8S
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BU of 7z8s by Molmil
Mot1:TBP:DNA - post hydrolysis state
分子名称: DNA (36-MER), Helicase-like protein, Putative tata-box binding protein
著者Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P.
登録日2022-03-18
公開日2023-03-29
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
Nat.Struct.Mol.Biol., 30, 2023
7Z7N
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BU of 7z7n by Molmil
Mot1E1434Q:TBP:DNA - substrate recognition state
分子名称: DNA (36-MER), Helicase-like protein, Putative tata-box binding protein
著者Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P.
登録日2022-03-16
公開日2023-03-29
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
Nat.Struct.Mol.Biol., 30, 2023
7ZB5
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BU of 7zb5 by Molmil
Mot1(1-1836):TBP:DNA - post-hydrolysis complex dimer
分子名称: DNA (36-MER), Helicase-like protein, Putative tata-box binding protein
著者Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P.
登録日2022-03-23
公開日2023-04-05
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
Nat.Struct.Mol.Biol., 30, 2023
1MD3
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BU of 1md3 by Molmil
A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, pi glutathione transferase
著者Kong, G.K.-W, Dragani, B, Aceto, A, Cocco, R, Mannervik, B, Stenberg, G, McKinstry, W.J, Polekhina, G, Parker, M.W.
登録日2002-08-06
公開日2002-08-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Contribution of Glycine 146 to a Conserved Folding Module Affecting Stability and Refolding of Human Glutathione Transferase P1-1
J.Biol.Chem., 278, 2003
5CFU
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BU of 5cfu by Molmil
Crystal Structure of ANT(2")-Ia in complex with adenylyl-2"-tobramycin
分子名称: 1,4-BUTANEDIOL, Aminoglycoside Nucleotidyltransferase (2")-Ia, MANGANESE (II) ION, ...
著者Rodionov, D, Bassenden, A.V, Berghuis, A.M.
登録日2015-07-08
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Revisiting the Catalytic Cycle and Kinetic Mechanism of AminoglycosideO-Nucleotidyltransferase(2′′): A Structural and Kinetic Study.
Acs Chem.Biol., 2020
2CCI
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BU of 2cci by Molmil
Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ...
著者Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
登録日2006-01-16
公開日2006-05-03
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
1JY0
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BU of 1jy0 by Molmil
Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).
分子名称: FORMIC ACID, acidic fibroblast growth factor
著者Brych, S.R, Blaber, M.
登録日2001-09-10
公開日2003-08-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Accommodation of a highly symmetric core within a symmetric protein superfold.
Protein Sci., 12, 2003
2UUE
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BU of 2uue by Molmil
REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
分子名称: 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID, 4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE, CELL DIVISION PROTEIN KINASE 2, ...
著者Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M.
登録日2007-03-02
公開日2007-03-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
Chembiochem, 7, 2006
2PF4
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BU of 2pf4 by Molmil
Crystal structure of the full-length simian virus 40 small t antigen complexed with the protein phosphatase 2A Aalpha subunit
分子名称: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Small T antigen, ZINC ION
著者Cho, U, Morrone, S, Xu, W.
登録日2007-04-03
公開日2007-08-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of PP2A inhibition by small t antigen.
Plos Biol., 5, 2007
4EON
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BU of 4eon by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306
分子名称: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
登録日2012-04-14
公開日2013-02-06
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOJ
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BU of 4eoj by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
登録日2012-04-14
公開日2013-02-06
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOK
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BU of 4eok by Molmil
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
分子名称: Cyclin-A2, Cyclin-dependent kinase 2, MONOTHIOGLYCEROL, ...
著者Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
登録日2012-04-14
公開日2013-02-06
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
4EOS
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BU of 4eos by Molmil
Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
分子名称: (5E)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Cyclin-A2, Cyclin-dependent kinase 2
著者Echalier, A, Cot, E, Camasses, A, Hodimont, E, Hoh, F, Sheinerman, F, Krasinska, L, Fisher, D.
登録日2012-04-14
公開日2013-02-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Chem.Biol., 19, 2012
2F2C
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BU of 2f2c by Molmil
X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol
分子名称: (2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Cell division protein kinase 6, Cyclin homolog, ...
著者Schulze-Gahmen, U, Lu, H.
登録日2005-11-16
公開日2006-06-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
8SG2
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BU of 8sg2 by Molmil
BIVALENT INTERACTIONS OF PIN1 WITH THE C-TERMINAL TAIL OF PKC
分子名称: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Protein kinase C beta type
著者Dixit, K, Yang, Y, Chen, X.R, Igumenova, T.I.
登録日2023-04-11
公開日2024-05-08
最終更新日2024-11-20
実験手法SOLUTION NMR
主引用文献A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation.
Elife, 13, 2024
2CCH
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BU of 2cch by Molmil
The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
著者Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
登録日2006-01-16
公開日2006-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
3QZT
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BU of 3qzt by Molmil
Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II
分子名称: GLYCEROL, Histone H4, Nucleosome-remodeling factor subunit BPTF
著者Li, H, Ruthenburg, A.J, Patel, D.J.
登録日2011-03-07
公開日2011-06-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions.
Cell(Cambridge,Mass.), 145, 2011

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