5XWR
| Crystal Structure of RBBP4-peptide complex | 分子名称: | Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE | 著者 | Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. | 登録日 | 2017-06-30 | 公開日 | 2018-07-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5XXQ
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5Y1U
| Crystal structure of RBBP4 bound to AEBP2 RRK motif | 分子名称: | Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 | 著者 | Sun, A, Li, F, Wu, J, Shi, Y. | 登録日 | 2017-07-21 | 公開日 | 2018-04-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.141 Å) | 主引用文献 | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein Cell, 2017
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6Q7K
| ERK2 mini-fragment binding | 分子名称: | 1H-imidazol-2-amine, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-13 | 公開日 | 2019-03-27 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QA3
| ERK2 mini-fragment binding | 分子名称: | Mitogen-activated protein kinase 1, PYRAZOLE, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-18 | 公開日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QA1
| ERK2 mini-fragment binding | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION, pyridin-2-amine | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-18 | 公開日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QAG
| ERK2 mini-fragment binding | 分子名称: | 1~{H}-1,2,3-triazole, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-19 | 公開日 | 2019-03-27 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QA4
| ERK2 mini-fragment binding | 分子名称: | 1~{H}-pyridin-2-one, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-18 | 公開日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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7EGM
| The SRM module of SWI/SNF-nucleosome complex | 分子名称: | SWI/SNF chromatin-remodeling complex subunit SNF5, SWI/SNF chromatin-remodeling complex subunit SWI1, SWI/SNF complex subunit SWI3, ... | 著者 | Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. | 登録日 | 2021-03-24 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discov, 7, 2021
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6QAL
| ERK2 mini-fragment binding | 分子名称: | 1,1-bis(oxidanylidene)thietan-3-ol, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-19 | 公開日 | 2019-03-27 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QAW
| ERK2 mini-fragment binding | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION, [1-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methylazanium | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-19 | 公開日 | 2019-03-27 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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6QAQ
| ERK2 mini-fragment binding | 分子名称: | Mitogen-activated protein kinase 1, SULFATE ION, thiophen-3-ylmethylazanium | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-19 | 公開日 | 2019-03-27 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
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8WQH
| cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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8WQB
| Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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8WQF
| cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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8EI3
| Crystal structure of VHL in complex with H313, a Helicon Polypeptide | 分子名称: | Elongin-B, Elongin-C, H313, ... | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | 登録日 | 2022-09-14 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Nat Commun, 14, 2023
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8WQE
| Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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8WQA
| Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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7ZLO
| Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 12 | 分子名称: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLP
| Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9 | 分子名称: | Elongin-B, Elongin-C, PHOSPHATE ION, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLN
| Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11 | 分子名称: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLS
| co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | 分子名称: | 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLR
| Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13 | 分子名称: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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7ZLM
| Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551 | 分子名称: | Elongin-B, Elongin-C, Suppressor of cytokine signaling 2, ... | 著者 | Ramachandran, S, Ciulli, A, Makukhin, N. | 登録日 | 2022-04-15 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nat Commun, 14, 2023
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6EZE
| The open conformation of E.coli Elongation Factor Tu in complex with GDPNP. | 分子名称: | DI(HYDROXYETHYL)ETHER, Elongation factor Tu 2, GLYCEROL, ... | 著者 | Johansen, J.S, Blaise, M, Thirup, S.S. | 登録日 | 2017-11-15 | 公開日 | 2018-08-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form. Nucleic Acids Res., 46, 2018
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