PDB: 1371 件ウェブページステータス検索Chemie searchBIRD

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5HIW	Sorangium cellulosum So Ce56 cytochrome P450 260B1 分子名称: Cytochrome P450 CYP260B1, MAGNESIUM ION, PROTOPORPHYRIN IX CONTAINING FE 著者 Salamanca-Pinzon, S.G, Carius, Y, Khatri, Y, Bernhardt, R, Lancaster, C.R.D. 登録日 2016-01-12 公開日 2016-08-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure-function analysis for the hydroxylation of Delta 4 C21-steroids by the myxobacterial CYP260B1. Febs Lett., 590, 2016
5VEU	Human Cytochrome P450 3A5 (CYP3A5) 分子名称: Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR 著者 Hsu, M.-H, Johnson, E.F. 登録日 2017-04-05 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5. Mol. Pharmacol., 93, 2018
5HS1	Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole 著者 Sabherwal, M, Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. 登録日 2016-01-24 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
1FAG	STRUCTURE OF CYTOCHROME P450 分子名称: CYTOCHROME P450 BM-3, PALMITOLEIC ACID, PROTOPORPHYRIN IX CONTAINING FE 著者 Li, H.Y, Poulos, T.L. 登録日 1996-08-01 公開日 1997-02-12 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid. Nat.Struct.Biol., 4, 1997
1EA1	Cytochrome P450 14 alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with fluconazole 分子名称: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, CYTOCHROME P450 51-LIKE RV0764C, PROTOPORPHYRIN IX CONTAINING FE 著者 Podust, L.M, Poulos, T.L, Waterman, M.R. 登録日 2000-11-02 公開日 2000-11-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal Structure of Cytochrome P450 14Alpha -Sterol Demethylase (Cyp51) from Mycobacterium Tuberculosis in Complex with Azole Inhibitors Proc.Natl.Acad.Sci.USA, 98, 2001
5X23	Crystal structure of CYP2C9 genetic variant A477T (*30) in complex with multiple losartan molecules 分子名称: Cytochrome P450 2C9, PHOSPHATE ION, POTASSIUM ION, ... 著者 Maekawa, K, Adachi, M, Shah, M.B. 登録日 2017-01-30 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry, 56, 2017
5IBF	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 19a 分子名称: 4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IKI	CYP106A2 WITH SUBSTRATE ABIETIC ACID 分子名称: Abietic acid, Cytochrome P450(MEG), PROTOPORPHYRIN IX CONTAINING FE 著者 Janocha, S, Carius, Y, Bernhardt, R, Lancaster, C.R.D. 登録日 2016-03-03 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound Form. Chembiochem, 17, 2016
1GWI	The 1.92 A structure of Streptomyces coelicolor A3(2) CYP154C1: A new monooxygenase that functionalizes macrolide ring systems 分子名称: CYTOCHROME P450 154C1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Podust, L.M, Kim, Y, Arase, M, Neely, B.A, Beck, B.J, Bach, H, Sherman, D.H, Lamb, D.C, Kelly, S.L, Waterman, M.R. 登録日 2002-03-15 公開日 2003-01-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The 1.92 A Structure of Streptomyces Coelicolor A3(2) Cyp154C1: A New Monooxygenase that Functionalizes Macrolide Ring Systems J.Biol.Chem., 278, 2003
5VCC	Crystal structure of human CYP3A4 bound to glycerol 分子名称: 1,2-ETHANEDIOL, Cytochrome P450 3A4, GLYCEROL, ... 著者 Sevrioukova, I. 登録日 2017-03-31 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4. Biochemistry, 56, 2017
5IRV	Human cytochrome P450 17A1 bound to inhibitor VT-464 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Steroid 17-alpha-hydroxylase/17,20 lyase, VT-464 著者 Scott, E.E, Petrunak, E.M. 登録日 2016-03-14 公開日 2017-03-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.098 Å) 主引用文献 Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Drug Metab. Dispos., 45, 2017
5IBI	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 26a 分子名称: 4,4'-(5-{[(4-hydroxyphenyl)methyl]amino}-1H-pyrazole-3,4-diyl)diphenol, Cytochrome P450 121 CYP121, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5IBE	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 25a 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[5-amino-4-(3'-amino[1,1'-biphenyl]-3-yl)-1H-pyrazol-3-yl]phenol, Mycocyclosin synthase, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.624 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5WK9	R186AP450cam with CN and camphor 分子名称: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... 著者 Poulos, T.L, Batabyal, D. 登録日 2017-07-24 公開日 2017-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.983 Å) 主引用文献 Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
5IBD	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 24a 分子名称: 4-(3'-amino[1,1'-biphenyl]-3-yl)-3-(4-methoxyphenyl)-1H-pyrazol-5-amine, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5WP2	1.44 Angstrom crystal structure of CYP121 from Mycobacterium tuberculosis in complex with substrate and CN 分子名称: (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, CYANIDE ION, Mycocyclosin synthase, ... 著者 Fielding, A, Dornevil, K, Liu, A. 登録日 2017-08-03 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.439 Å) 主引用文献 Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature. J. Am. Chem. Soc., 139, 2017
5IT1	Streptomyces peucetius CYP105P2 complex with biphenyl compound 分子名称: 4,4'-PROPANE-2,2-DIYLDIPHENOL, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 著者 Lee, C.W, Lee, J.H. 登録日 2016-03-16 公開日 2016-06-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Cytochrome P450 (CYP105P2) from Streptomyces peucetius and Its Conformational Changes in Response to Substrate Binding Int J Mol Sci, 17, 2016
5XA3	Crystal Structure of P450BM3 with Benzyloxycarbonyl-L-prolyl-L-phenylalanine 分子名称: Bifunctional cytochrome P450/NADPH-P450 reductase, DIMETHYL SULFOXIDE, PHENYLALANINE, ... 著者 Shoji, O, Yanagisawa, S, Stanfield, J.K, Suzuki, K, Kasai, C, Cong, Z, Sugimoto, H, Shiro, Y, Watanabe, Y. 登録日 2017-03-10 公開日 2018-02-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives. Angew. Chem. Int. Ed. Engl., 56, 2017
5IBJ	Crystal structure Mycobacterium tuberculosis CYP121 in complex with inhibitor fragment 6 分子名称: 4-{5-[(4-hydroxyphenyl)amino]-1H-pyrazol-3-yl}phenol, Cytochrome P450 121 CYP121, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C. 登録日 2016-02-22 公開日 2016-04-06 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J.Med.Chem., 59, 2016
5WK7	P450cam mutant R186A 分子名称: 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Batabyal, D, Poulos, T.L. 登録日 2017-07-24 公開日 2017-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.983 Å) 主引用文献 Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
1GEJ	STRUCTURAL CHARACTERIZATION OF N-BUTYL-ISOCYANIDE COMPLEXES OF CYTOCHROMES P450NOR AND P450CAM 分子名称: CYTOCHROME P450 55A1, N-BUTYL ISOCYANIDE, PROTOPORPHYRIN IX CONTAINING FE 著者 lee, D.-S, Park, S.-Y, Yamane, K, Shiro, Y. 登録日 2000-11-13 公開日 2000-12-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural characterization of n-butyl-isocyanide complexes of cytochromes P450nor and P450cam. Biochemistry, 40, 2001
5UVB	The crystal structure of 4-cyclopropylbenzoate-bound CYP199A4 分子名称: 4-cyclopropylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... 著者 Coleman, T, Bruning, J.B, Bell, S.G. 登録日 2017-02-20 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 The crystal structure of 4-cyclopropylbenzoate-bound CYP199A4 To Be Published
5FYG	Structure of CYP153A from Marinobacter aquaeolei in complex with hydroxydodecanoic acid 分子名称: 12-HYDROXYDODECANOIC ACID, CYTOCHROME P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Danesh-Azari, H.-R, Spandolf, C, Hoffman, S.M, Weissenborn, M, Hauer, B, Grogan, G. 登録日 2016-03-07 公開日 2017-01-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structure-Guided Redesign of CYP153AM.aqfor the Improved Terminal Hydroxylation of Fatty Acids Chemcatchem, 2016
5IK1	Open state of P450cam after soaking in camphor 分子名称: CAMPHOR, Camphor 5-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE 著者 Mahomed, M, Goodin, D.B, Lee, Y.-T. 登録日 2016-03-03 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Effector Roles of Putidaredoxin on Cytochrome P450cam Conformational States. J.Am.Chem.Soc., 138, 2016
5XJN	cytochrome P450 CREJ in complex with (4-ethylphenyl) dihydrogen phosphate 分子名称: (4-ethylphenyl) dihydrogen phosphate, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Dong, S, Du, L, Li, S, Feng, Y. 登録日 2017-05-03 公開日 2017-07-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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