4HXZ
 
 | | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | | 分子名称: | 6-ethyl-4-methoxy-2-(pyridin-3-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, Topoisomerase IV, subunit B | | 著者 | Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. | | 登録日 | 2012-11-12 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
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4HYM
 | | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | | 分子名称: | 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one, Topoisomerase IV, subunit B | | 著者 | Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. | | 登録日 | 2012-11-13 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett., 23, 2013
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4JAU
 | | Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase | | 著者 | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | | 登録日 | 2013-02-19 | | 公開日 | 2013-09-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling
Structure, 21, 2013
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4JPB
 | | The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an unzipped fragment of TM14, a chemoreceptor analog from Thermotoga maritima. | | 分子名称: | Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein | | 著者 | Li, X, Bayas, C, Bilwes, A.M, Crane, B.R. | | 登録日 | 2013-03-19 | | 公開日 | 2013-08-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.186 Å) | | 主引用文献 | The 3.2 angstrom resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
Biochemistry, 52, 2013
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4JAS
 | | Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase, MAGNESIUM ION, ... | | 著者 | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | | 登録日 | 2013-02-19 | | 公開日 | 2013-09-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling
Structure, 21, 2013
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4JUO
 | | A low-resolution three-gate structure of topoisomerase IV from Streptococcus pneumoniae in space group H32 | | 分子名称: | (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid, DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, ... | | 著者 | Laponogov, I, Veselkov, D.A, Pan, X.-S, Crevel, I, Fisher, L.M, Sanderson, M.R. | | 登録日 | 2013-03-25 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (6.53 Å) | | 主引用文献 | Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
Nucleic Acids Res., 41, 2013
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4JAV
 | | Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Histidine kinase, ... | | 著者 | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | | 登録日 | 2013-02-19 | | 公開日 | 2013-09-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling
Structure, 21, 2013
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4KP4
 | | Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases. | | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Osmolarity sensor protein EnvZ, ... | | 著者 | Casino, P, Miguel-Romero, L, Marina, A. | | 登録日 | 2013-05-13 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Visualizing autophosphorylation in histidine kinases.
Nat Commun, 5, 2014
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4KQV
 | | Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor | | 分子名称: | 6-fluoro-4-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-N-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9H-pyrimido[4,5-b]indol-8-amine, IODIDE ION, Topoisomerase IV, ... | | 著者 | Bensen, D.C, Akers-Rodriguez, S, Lam, T, Tari, L.W. | | 登録日 | 2013-05-15 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | A new class of type iia topoisomerase inhibitors with
broad-spectrum antibacterial activity
To be Published
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