PDB: 22634 件ウェブページステータス検索Chemie searchBIRD

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4XTW	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 46 with azide in place of 2'OH 分子名称: 1,2-ETHANEDIOL, 2'-azido-2',5'-dideoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, Bifunctional ligase/repressor BirA 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.30014467 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XTZ	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a fluorine in place of the ribose 2'OH 分子名称: 9-[2-deoxy-2-fluoro-5-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)-beta-D-arabinofuranosyl]-9H-purin-6-amine, Bifunctional ligase/repressor BirA 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.90000677 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XU2	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 87 with a 3'deoxy ribose 分子名称: 3',5'-dideoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, Bifunctional ligase/repressor BirA 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8500284 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
6AX8	Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate 分子名称: Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate 著者 Barros-Alvarez, X, Hol, W.G.J. 登録日 2017-09-06 公開日 2018-04-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallogr F Struct Biol Commun, 74, 2018
4XU0	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 73 that has a 2'-methyl on the ribose 分子名称: 2'-C-methyl-5'-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)adenosine, Bifunctional ligase/repressor BirA 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.60000169 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XTV	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide) 分子名称: Bifunctional ligase/repressor BirA, N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45000839 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XU1	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates a morpholine in place of the ribose 分子名称: 1,2-ETHANEDIOL, Bifunctional ligase/repressor BirA, DIMETHYL SULFOXIDE, ... 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.70001328 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
4XU3	Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose 分子名称: Bifunctional ligase/repressor BirA, CHLORIDE ION, N-({2-[(6-amino-9H-purin-9-yl)methoxy]ethyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide 著者 De la Mora-Rey, T, Finzel, B.C. 登録日 2015-01-24 公開日 2015-09-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.242677 Å) 主引用文献 Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015
1QTO	1.5 A CRYSTAL STRUCTURE OF A BLEOMYCIN RESISTANCE DETERMINANT FROM BLEOMYCIN-PRODUCING STREPTOMYCES VERTICILLUS 分子名称: BLEOMYCIN-BINDING PROTEIN 著者 Kawano, Y, Kumagai, T, Muta, K, Matoba, Y, Davies, J, Sugiyama, M. 登録日 1999-06-28 公開日 2000-06-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The 1.5 A crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus. J.Mol.Biol., 295, 2000
3M9H	Crystal structure of the amino terminal coiled coil domain of the Mycobacterium tuberculosis proteasomal ATPase Mpa 分子名称: Proteasome-associated ATPase 著者 Li, H, Wang, T. 登録日 2010-03-22 公開日 2010-10-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat.Struct.Mol.Biol., 17, 2010
5DRI	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(1H-indol-5-yl)-4-oxobut-2-enoic acid inhibitor 分子名称: (2Z)-2-hydroxy-4-(1H-indol-5-yl)-4-oxobut-2-enoic acid, MAGNESIUM ION, Malate synthase G 著者 Krieger, I.V, Huang, H.-L, Sacchettini, J.C. 登録日 2015-09-15 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. J. Biol. Chem., 291, 2016
4WXC	Crystal structure of Mycobacterium tuberculosis OGT-Y139F 分子名称: 1,2-ETHANEDIOL, Methylated-DNA--protein-cysteine methyltransferase 著者 Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M. 登録日 2014-11-13 公開日 2015-11-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA. Biochem.J., 473, 2016
4UBW	Apo structure of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis 分子名称: Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Schaefer, C.M, Kisker, C. 登録日 2014-08-13 公開日 2014-12-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis. Structure, 23, 2015
6BS8	The class 3 DnaB intein from Mycobacterium smegmatis 分子名称: Replicative DNA helicase 著者 Li, Z, Kelley, D.S, Banavali, N, Belfort, M, Li, H. 登録日 2017-12-01 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mycobacterial DnaB helicase intein as oxidative stress sensor. Nat Commun, 9, 2018
4WX9	Crystal structure of Mycobacterium tuberculosis OGT in complex with DNA 分子名称: DNA (5'-D(*GP*CP*CP*AP*TP*GP*(E1X)P*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'), GLYCEROL, ... 著者 Miggiano, R, Rossi, F, Garavaglia, S, Rizzi, M. 登録日 2014-11-13 公開日 2015-11-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA. Biochem.J., 473, 2016
4W2I	Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Polikanov, Y.S, Szal, T, Jiang, F, Gupta, P, Matsuda, R, Shiozuka, M, Steitz, T.A, Vazquez-Laslop, N, Mankin, A.S. 登録日 2014-09-12 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA. Mol.Cell, 56, 2014
1R88	The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1) 分子名称: MPT51/MPB51 antigen 著者 Wilson, R.A, Maughan, W.N, Kremer, L, Besra, G.S, Futterer, K. 登録日 2003-10-23 公開日 2003-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases. J.Mol.Biol., 335, 2004
3M4I	Crystal structure of the second part of the Mycobacterium tuberculosis DNA gyrase reaction core: the TOPRIM domain at 1.95 A resolution 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA gyrase subunit B 著者 Piton, J, Petrella, S, Aubry, A, Mayer, C. 登録日 2010-03-11 公開日 2010-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase. Plos One, 5, 2010
6A2S	Mycobacterium tuberculosis LexA C-domain S160A 分子名称: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LexA repressor 著者 Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment. Acta Crystallogr D Struct Biol, 75, 2019
6A2Q	Mycobacterium tuberculosis LexA C-domain I 分子名称: GLYCEROL, LexA repressor 著者 Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment. Acta Crystallogr D Struct Biol, 75, 2019
6ACA	Crystal structure of Mycobacterium tuberculosis Mfd at 3.6 A resolution 分子名称: Mycobacterium tuberculosis Mfd 著者 Putta, S, Fox, G.C, Walsh, M.A, Rao, D.N, Nagaraja, V, Natesh, R. 登録日 2018-07-26 公開日 2019-08-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis for nucleotide-mediated remodelling mechanism of Mycobacterium Mfd To Be Published
6A2R	Mycobacterium tuberculosis LexA C-domain II 分子名称: DI(HYDROXYETHYL)ETHER, LexA repressor 著者 Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment. Acta Crystallogr D Struct Biol, 75, 2019
6A2T	Mycobacterium tuberculosis LexA C-domain K197A 分子名称: ACRYLIC ACID, LexA repressor 著者 Chandran, A.V, Srikalaivani, R, Paul, A, Vijayan, M. 登録日 2018-06-12 公開日 2019-01-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment. Acta Crystallogr D Struct Biol, 75, 2019
1RQ7	MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP 分子名称: Cell division protein ftsZ, GUANOSINE-5'-DIPHOSPHATE 著者 Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W. 登録日 2003-12-04 公開日 2004-08-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J.Mol.Biol., 342, 2004
1RQ2	MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH CITRATE 分子名称: CITRIC ACID, Cell division protein ftsZ 著者 Leung, A.K.W, White, E.L, Ross, L.J, Reynolds, R.C, DeVito, J.A, Borhani, D.W. 登録日 2003-12-04 公開日 2004-08-31 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J.Mol.Biol., 342, 2004

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