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6E2O
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ASK1 kinase domain complex with inhibitor
分子名称: 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]pyridine-2-carboxamide, Mitogen-activated protein kinase kinase kinase 5
著者Lansdon, E.B.
登録日2018-07-11
公開日2018-09-19
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.389 Å)
主引用文献ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
J. Clin. Invest., 128, 2018
3L0D
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Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Bartonella henselae with bound NAD
分子名称: Glyceraldehyde 3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2009-12-09
公開日2009-12-29
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Bartonella henselae with bound NAD
To be Published
5JOH
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CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-1b
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-chloro-6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-carbonitrile, COP9 signalosome complex subunit 5, ...
著者Renatus, M, Wiesmann, C.
登録日2016-05-02
公開日2016-11-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nat Commun, 7, 2016
3L81
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Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
分子名称: AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL
著者Mardones, G.A, Rojas, A.L, Burgos, P.V, Dasilva, L.L.P, Prabhu, Y, Bonifacino, J.S, Hurley, J.H.
登録日2009-12-29
公開日2010-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Dev.Cell, 18, 2010
3LV0
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Crystal structure of extragenic suppressor protein suhB from Bartonella henselae, native
分子名称: Extragenic suppressor protein suhB, MAGNESIUM ION
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2010-02-18
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of extragenic suppressor protein suhB from Bartonella henselae
To be Published
6EPN
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Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F2
分子名称: 1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-ethanone, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V.
登録日2017-10-12
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
4WSN
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BU of 4wsn by Molmil
Crystal structure of the COP9 signalosome, a P1 crystal form
分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
著者Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
登録日2014-10-28
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (5.5 Å)
主引用文献Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature, 531, 2016
5LKS
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Structure-function insights reveal the human ribosome as a cancer target for antibiotics
分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
著者Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P.
登録日2016-07-23
公開日2017-04-26
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
1X95
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Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)
分子名称: 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM, 5'-D(*AP*TP*GP*CP*AP*T)-3'
著者Dai, J, Punchihewa, C, Mistry, P, Ooi, A.T, Yang, D.
登録日2004-08-19
公開日2004-09-28
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.
J.Biol.Chem., 279, 2004
1X67
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Solution structure of the cofilin homology domain of HIP-55 (drebrin-like protein)
分子名称: Drebrin-like protein
著者Goroncy, A.K, Kigawa, T, Koshiba, S, Sato, M, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-17
公開日2005-11-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献NMR solution structures of actin depolymerizing factor homology domains.
Protein Sci., 18, 2009
1Z3Q
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BU of 1z3q by Molmil
Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A
分子名称: 1,2-ETHANEDIOL, Thaumatin-like Protein
著者Leone, P, Menu-Bouaouiche, L, Peumans, W.J, Barre, A, Payan, F, Roussel, A, Van Damme, E.J.M, Rouge, P.
登録日2005-03-14
公開日2006-01-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A
Biochimie, 88, 2006
5M5Q
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COPS5(2-257) IN COMPLEX WITH A AZAINDOLE (COMPOUND 4)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-[(3~{R})-3-(1~{H}-benzimidazol-2-yl)morpholin-4-yl]-3-[2-(4-methyl-2-phenyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]propan-1-one, COP9 signalosome complex subunit 5, ...
著者Renatus, M, Altmann, E.
登録日2016-10-22
公開日2017-01-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Angew. Chem. Int. Ed. Engl., 56, 2017
5NUZ
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BU of 5nuz by Molmil
Junin virus GP1 glycoprotein in complex with an antibody Fab fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ISOPROPYL ALCOHOL, ...
著者Zeltina, A, Krumm, S.A, Sahin, M, Struwe, W.B, Harlos, K, Nunberg, J.H, Crispin, M, Pinschewer, D.D, Doores, K.J, Bowden, T.A.
登録日2017-05-03
公開日2017-06-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5O8K
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BU of 5o8k by Molmil
Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
分子名称: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B
著者Emamzadah, S, Tropia, L, Huber, F, Halazonetis, T.
登録日2017-06-13
公開日2018-06-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of mammalian Rev7 in complex with Rev3 1875-1895
To Be Published
5OA3
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Human 40S-eIF2D-re-initiation complex
分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Weisser, M, Schaefer, T, Leibundgut, M, Boehringer, D, Aylett, C.H.S, Ban, N.
登録日2017-06-20
公開日2017-08-09
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural and Functional Insights into Human Re-initiation Complexes.
Mol. Cell, 67, 2017
5OVD
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BU of 5ovd by Molmil
Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in new crystal form
分子名称: 1,2-ETHANEDIOL, Son of sevenless homolog 1
著者Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V.
登録日2017-08-28
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6QZP
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BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
分子名称: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
著者Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
登録日2019-03-12
公開日2019-04-24
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
6R7F
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Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
著者Faull, S.V, Lau, A.M.C, Martens, C, Ahdash, Z, Yebenes, H, Schmidt, C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
登録日2019-03-28
公開日2019-08-28
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (8.2 Å)
主引用文献Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7S
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Human Serum Albumin, complexed with Sulfasalazine
分子名称: 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, DIMETHYL SULFOXIDE, SULFATE ION, ...
著者Schreuder, H.A, Liesum, A.
登録日2019-03-29
公開日2020-04-08
最終更新日2020-05-13
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Resolving Binding Events on the Multifunctional Human Serum Albumin.
Chemmedchem, 15, 2020
7LUO
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BU of 7luo by Molmil
N-terminus of Skp2 bound to Cyclin A
分子名称: S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2
著者Kelso, S, Ceccarelli, D.F, Sicheri, F.
登録日2021-02-22
公開日2021-05-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Bipartite binding of the N terminus of Skp2 to cyclin A.
Structure, 29, 2021
6R7H
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Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
著者Faull, S.V, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
登録日2019-03-28
公開日2019-08-28
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (8.8 Å)
主引用文献Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7I
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Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
著者Faull, S.F, Lau, A.M.C, Beuron, F, Cronin, N.B, Morris, E.P, Politis, A.
登録日2019-03-28
公開日2019-08-28
最終更新日2019-09-04
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R55
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Crystal structure of PPEP-1(E184K)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION
著者Pichlo, C, Baumann, U.
登録日2019-03-24
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
J.Biol.Chem., 294, 2019
6R6H
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Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
分子名称: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
著者Morris, E.P, Faull, S.V, Lau, A.M.C, Politis, A, Beuron, F, Cronin, N.
登録日2019-03-27
公開日2019-08-28
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (8.4 Å)
主引用文献Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R52
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Crystal structure of PPEP-1(K101A)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Pro-Pro endopeptidase, ZINC ION
著者Pichlo, C, Baumann, U.
登録日2019-03-24
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.022 Å)
主引用文献Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
J.Biol.Chem., 294, 2019

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