1ELV
 
 | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE | | 分子名称: | 2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C1S COMPONENT, ... | | 著者 | Gaboriaud, C, Rossi, V, Bally, I, Arlaud, G, Fontecilla-Camps, J.-C. | | 登録日 | 2000-03-14 | | 公開日 | 2001-03-14 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.
EMBO J., 19, 2000
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8KB2
 | | Crystal Structure of M- and C-Domains of the shaft pilin LrpA from Ligilactobacillus ruminis - iodide derivative | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | Prajapati, A, Palva, A, von Ossowski, I, Krishnan, V. | | 登録日 | 2023-08-03 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | The crystal structure of the N-terminal domain of the backbone pilin LrpA reveals a new closure-and-twist motion for assembling dynamic pili in Ligilactobacillus ruminis.
Acta Crystallogr D Struct Biol, 80, 2024
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9QUL
 | | Zn(II)-bound de novo protein scaffold TFD-EH T87E | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, IMIDAZOLE, ... | | 著者 | Wagner Egea, P, Delhommel, F, Mustafa, G, Leiss-Maier, F, Klimper, L, Badmann, T, Heider, A, Wille, I.C, Groll, M, Sattler, M, Zeymer, C. | | 登録日 | 2025-04-10 | | 公開日 | 2025-11-19 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Modular protein scaffold architecture and AI-guided sequence optimization facilitate de novo metalloenzyme engineering.
Structure, 2025
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7AE6
 | | Crystal structure of di-AMPylated HEPN(R102A) toxin | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, HEPN toxin | | 著者 | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | | 登録日 | 2020-09-17 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation.
Mol.Cell, 80, 2020
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5W0T
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9QBA
 | | Human TRIM21 PRYSPRY domain in complex with AL236 | | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase TRIM21, ~{N}-(cyclohexylmethyl)-4-(4-fluoranyl-2-methylsulfanyl-phenyl)-2-methylsulfonyl-benzamide | | 著者 | Kim, Y, Lucic, A, Knapp, S, Kraemer, A, Structural Genomics Consortium (SGC) | | 登録日 | 2025-03-01 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-09-24 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain.
Commun Chem, 8, 2025
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7SPA
 | | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7O0M
 | | Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023) | | 分子名称: | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Dolbois, A, Caflisch, A. | | 登録日 | 2021-03-26 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023)
To Be Published
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7O1U
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6V6U
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7SP6
 | | Chlorella virus hyaluronan synthase | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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8YSX
 | | canine immunoproteasome 20S subunit in complex with compound 2 | | 分子名称: | Proteasome subunit alpha type, Proteasome subunit beta, Proteasome subunit beta type-8, ... | | 著者 | Kashima, A, Arai, Y. | | 登録日 | 2024-03-24 | | 公開日 | 2024-07-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor.
Bioorg.Med.Chem., 109, 2024
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7SP8
 | | Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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8V35
 | | Crystal structure of HpsN from Cupriavidus pinatubonensis | | 分子名称: | 1,2-ETHANEDIOL, Sulfopropanediol 3-dehydrogenase, ZINC ION | | 著者 | Lee, M. | | 登録日 | 2023-11-27 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural and kinetic insights into the stereospecific oxidation of R -2,3-dihydroxypropanesulfonate by DHPS-3-dehydrogenase from Cupriavidus pinatubonensis.
Chem Sci, 15, 2024
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7SP7
 | | Chlorella virus hyaluronan synthase inhibited by UDP | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | 著者 | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | 登録日 | 2021-11-02 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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8KEP
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7O28
 | | Crystal structure of the human METTL3-METTL14 complex bound to Compound 19 (ADO_AE_009) | | 分子名称: | 9-(2-chloranyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)-4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Dolbois, A, Caflisch, A. | | 登録日 | 2021-03-30 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 19 (ADO_AE_009)
To Be Published
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7O0R
 | | Crystal structure of the human METTL3-METTL14 complex bound to Compound 15 (ADO_AE_026) | | 分子名称: | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-(propan-2-ylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Dolbois, A, Caflisch, A. | | 登録日 | 2021-03-26 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 15 (ADO_AE_026)
To Be Published
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6UZS
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8V36
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9XY2
 | | One of a series of engineered variants of I-OnuI meganuclease targeting altered DNA target sequence | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Werther, R, Schwensen, J.S, Stoddard, B.L. | | 登録日 | 2025-08-25 | | 公開日 | 2025-09-10 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Prediction, modeling and design of protein-DNA recognition via computational and machine learning approaches:
accomplishments and remaining challenges
To Be Published
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8EFN
 | | Structure of Sp-STING3 from Stylophora pistillata coral in complex with 3',3'-cGAMP | | 分子名称: | 1,2-ETHANEDIOL, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon genes protein | | 著者 | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | | 登録日 | 2022-09-08 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023
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1EKI
 | | AVERAGE SOLUTION STRUCTURE OF D(TTGGCCAA)2 BOUND TO CHROMOMYCIN-A3 AND COBALT | | 分子名称: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-4-O-acetyl-2,6-dideoxy-beta-D-galactopyranose, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-beta-D-Olivopyranose-(1-3)-beta-D-Olivopyranose, ... | | 著者 | Gochin, M. | | 登録日 | 2000-03-08 | | 公開日 | 2000-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A high-resolution structure of a DNA-chromomycin-Co(II) complex determined from pseudocontact shifts in nuclear magnetic resonance.
Structure Fold.Des., 8, 2000
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9NZ3
 | | SARS-CoV M protein dimer in complex with JNJ-9676 and FAb B | | 分子名称: | (6S,8R)-N-(3-cyanophenyl)-5-{4-[difluoro(phenyl)methyl]phenyl}-6-methyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-3-carboxamide, FAb B heavy chain, FAb B light chain, ... | | 著者 | Mann, M.K, Abeywickrema, P. | | 登録日 | 2025-03-31 | | 公開日 | 2025-10-29 | | 最終更新日 | 2025-12-03 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Structural insights into MERS and SARS coronavirus membrane proteins
Commun Biol, 8, 2025
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7NW1
 | | Crystal structure of UFC1 in complex with UBA5 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Manoj Kumar, P, Padala, P, Isupov, M.N, Wiener, R. | | 登録日 | 2021-03-16 | | 公開日 | 2021-09-29 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural basis for UFM1 transfer from UBA5 to UFC1.
Nat Commun, 12, 2021
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