PDB: 7742 件ウェブページステータス検索Chemie searchBIRD

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5W1M	MACV GP1 CR1-07 Fab complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR1-07 Fab heavy chain, ... 著者 Raymond, D.D, Clark, L.E, Abraham, J. 登録日 2017-06-03 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.91 Å) 主引用文献 Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun, 9, 2018
5W1G	CR1-07 unliganded Fab 分子名称: CR1-07 Fab heavy chain, CR1-07 Fab light chain 著者 Raymond, D.D, Clark, L.E, Abraham, J. 登録日 2017-06-03 公開日 2018-05-30 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun, 9, 2018
4IEF	Complex of Porphyromonas gingivalis RgpB pro- and mature domains 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BARIUM ION, CALCIUM ION, ... 著者 de Diego, I, Veillard, F.T, Guevara, T, Potempa, B, Sztukowska, M, Potempa, J, Gomis-Ruth, F.X. 登録日 2012-12-13 公開日 2013-04-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases. J.Biol.Chem., 288, 2013
4OD2	Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5 分子名称: Fab fragment of drozitumab, heavy chain, light chain, ... 著者 Hymowitz, S.G, Compaan, D. 登録日 2014-01-09 公開日 2014-02-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ., 15, 2008
4G3G	Crystal structure of murine NF-kappaB inducing kinase (NIK) V408L bound to a 2-(aminothiazolyl)phenol (cmp3) 分子名称: 4-fluoro-2-{[4-(pyridin-4-yl)-1,3-thiazol-2-yl]amino}phenol, NF-kappa-beta-inducing kinase 著者 Hymowitz, S. 登録日 2012-07-13 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
4A3U	X-structure of the old yellow enzyme homologue from zymomonas mobilis (NCR) 分子名称: ACETATE ION, FLAVIN MONONUCLEOTIDE, NADH:FLAVIN OXIDOREDUCTASE/NADH OXIDASE, ... 著者 Hoeffken, H.W. 登録日 2011-10-04 公開日 2012-10-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure Determination and Mutagenesis Analysis of the Ene Reductase Ncr. Chembiochem, 13, 2012
6XCJ	Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DH650 Fab Heavy Chain, DH650 Fab Light Chain, ... 著者 Raymond, D.D, Chug, H, Harrison, S.C. 登録日 2020-06-08 公開日 2020-12-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science, 371, 2021
2BEA	Crystal structure of Asn14 to Gly mutant of WCI 分子名称: Chymotrypsin inhibitor 3 著者 Dattagupta, J.K, Sen, U, Dasgupta, J, Khamrui, S. 登録日 2005-10-24 公開日 2006-06-13 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Spacer Asn Determines the Fate of Kunitz (STI) Inhibitors, as Revealed by Structural and Biochemical Studies on WCI Mutants. Biochemistry, 45, 2006
4NB6	Crystal structure of the ligand binding domain of RORC with T0901317 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma 著者 Hymowitz, S.G, Boenig-de Leon, G. 登録日 2013-10-22 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23, 2013
4OTF	Crystal structure of the kinase domain of Bruton's Tyrosine kinase with GDC0834 分子名称: N-{3-[6-({4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl }-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, SULFATE ION, Tyrosine-protein kinase BTK 著者 Hymowitz, S.G, Maurer, B. 登録日 2014-02-13 公開日 2015-01-28 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834. Bioorg.Med.Chem.Lett., 25, 2015
4G3E	Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1) 分子名称: (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, NF-kappa-beta-inducing kinase, SULFATE ION 著者 Hymowitz, S.G, de Leon-Boenig, G. 登録日 2012-07-13 公開日 2012-08-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
4G3F	Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2) 分子名称: 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile, NF-kappa-beta-inducing kinase 著者 Hymowitz, S.G, de Leon-Boenig, G. 登録日 2012-07-13 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.642 Å) 主引用文献 The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure, 20, 2012
3MXV	Crystal structure of fab fragment of anti-Shh 5E1 chimera 分子名称: SULFATE ION, fab fragment of anti-Shh 5E1 mouse/human chimera, heavy chain, ... 著者 Hymowitz, S.G, Maun, H.R. 登録日 2010-05-07 公開日 2010-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J.Biol.Chem., 285, 2010
3MXW	Crystal structure Sonic hedgehog bound to the 5E1 fab fragment 分子名称: 5E1 heavy chain, 5E1 light chain, CALCIUM ION, ... 著者 Hymowitz, S.G, Maun, H.R. 登録日 2010-05-07 公開日 2010-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J.Biol.Chem., 285, 2010
2BBF	Crystal structure of tRNA-guanine transglycosylase (TGT) from Zymomonas mobilis in complex with 6-amino-3,7-dihydro-imidazo[4,5-g]quinazolin-8-one 分子名称: 6-AMINO-3,7-DIHYDRO-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, ZINC ION, tRNA guanine transglycosylase 著者 Stengl, B, Meyer, E.A, Heine, A, Brenk, R, Diederich, F, Klebe, G. 登録日 2005-10-17 公開日 2007-04-24 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. J.Mol.Biol., 370, 2007
2QII	Crystal Structure Of tRNA-Guanine Transglycosylase (TGT) From Zymomonas mobilis Complexed With Archaeosine Precursor, Preq0 分子名称: 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... 著者 Tidten, N, Brenk, R, Heine, A, Reuter, K, Klebe, G. 登録日 2007-07-04 公開日 2007-07-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies. J.Mol.Biol., 374, 2007
2LT5	Zymogen-FLG of the onconase 分子名称: Protein P-30 著者 Vilanova, M, Callis, M, Laurents, D.V, Ribo, M, Bruix, M, Serrano, S. 登録日 2012-05-14 公開日 2012-10-24 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献
2HEV	Crystal structure of the complex between OX40L and OX40 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4 著者 Hymowitz, S.G, Compaan, D.M. 登録日 2006-06-22 公開日 2006-08-29 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 The Crystal Structure of the Costimulatory OX40-OX40L Complex. Structure, 14, 2006
2HFG	Crystal structure of hBR3 bound to CB3s-Fab 分子名称: CB3s Fab heavy chain, CB3s Fab light chain (kappa), Tumor necrosis factor receptor superfamily member 13C 著者 Hymowitz, S.G. 登録日 2006-06-23 公開日 2006-11-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood, 108, 2006
2HEW	The X-ray crystal structure of murine OX40L 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor ligand superfamily member 4 著者 Hymowitz, S.G, Compaan, D.M. 登録日 2006-06-22 公開日 2006-08-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Crystal Structure of the Costimulatory OX40-OX40L Complex. Structure, 14, 2006
2H9G	Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5) 分子名称: Fab BdF1, heavy chain, light chain, ... 著者 Hymowitz, S.G, Compaan, D.M. 登録日 2006-06-09 公開日 2006-08-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists. J.Mol.Biol., 361, 2006
2HEY	Crystal structure of murine OX40L bound to human OX40 分子名称: SULFATE ION, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4 著者 Hymowitz, S.G. 登録日 2006-06-22 公開日 2006-08-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Crystal Structure of the Costimulatory OX40-OX40L Complex. Structure, 14, 2006
3LN4	Crystal structure of HLA-B*4103 in complex with a 16mer self-peptide derived from heterogeneous nuclear ribonucleoproteins C1/C2 分子名称: 16-mer peptide from Heterogeneous nuclear ribonucleoproteins C1/C2, ACETATE ION, Beta-2-microglobulin, ... 著者 Theodossis, A, Gras, S, Rossjohn, J. 登録日 2010-02-01 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.296 Å) 主引用文献 The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family Haematologica, 96, 2011
3LN5	Crystal structure of HLA-B*4104 in complex with a 11mer self-peptide derived from S-methyl-5-thioadenosine phosphorylase 分子名称: 11-mer peptide from S-methyl-5'-thioadenosine phosphorylase, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... 著者 Theodossis, A, Gras, S, Rossjohn, J. 登録日 2010-02-02 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family Haematologica, 96, 2011
2HFF	Crystal structure of CB2 Fab 分子名称: CB2 Fab, heavy chain, light chain 著者 Hymowitz, S.G. 登録日 2006-06-23 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. Blood, 108, 2006

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