PDB: 965 件ウェブページステータス検索Chemie searchBIRD

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4S2Z	ERK2 Intrinsically active mutant R65S 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-25 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S34	ERK2 (I84A) in complex with AMP-PNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S32	Crystal structure of ERK2 AMP-PNP complex 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Crystal structure of ERK2 AMP-PNP complex To be Published
4S30	ERK2 intrinsically active mutant (I84A) 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S31	Crystal structure of mitogen-activated protein kinase 1 wtERK2 at 1.45A 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4S33	ERK2 R65S mutant complexed with AMP-PNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4U81	MEK1 Kinase bound to small molecule inhibitor G659 分子名称: 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Robarge, K.D, Ultsch, M.H, Weismann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4U0C	Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form 分子名称: Capsid protein p24, Nuclear pore complex protein Nup153 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0A	Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form 分子名称: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0E	Hexameric HIV-1 CA in complex with PF3450074 分子名称: CHLORIDE ION, Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.043 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4UED	Complex of human eIF4E with the 4E binding protein 4E-BP1 分子名称: EUKARYOTIC TRANSLATION FACTOR 4E-BINDING PROTEIN 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E 著者 Peter, D, Weichenrieder, O. 登録日 2014-12-16 公開日 2015-02-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E. Mol.Cell, 57, 2015
4U7Z	Mitogen-Activated Protein Kinase Kinase (MEK1) bound to G805 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Robarge, K.D, Ultsch, M.H, Wiesmann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.805 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4U80	MEK 1 kinase bound to G799 分子名称: 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Ultsch, M.H, Robarge, K.D, Weismann, C. 登録日 2014-07-31 公開日 2014-09-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
4U0F	Hexameric HIV-1 CA in Complex with BI-2 分子名称: (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one, 1,2-ETHANEDIOL, Capsid protein p24 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0B	Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form 分子名称: Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
4U0D	Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form 分子名称: CHLORIDE ION, Gag polyprotein, Nuclear pore complex protein Nup153 著者 Price, A.J, Jacques, D.A, James, L.C. 登録日 2014-07-11 公開日 2014-11-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly. Plos Pathog., 10, 2014
6PP9	Crystal structure of BRAF:MEK1 complex 分子名称: 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J. 登録日 2019-07-05 公開日 2019-10-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
6Q0K	Structure of a MAPK pathway complex 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf 著者 Park, E, Rawson, S, Jeon, H, Eck, M.J. 登録日 2019-08-01 公開日 2019-10-09 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
6Q7K	ERK2 mini-fragment binding 分子名称: 1H-imidazol-2-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-13 公開日 2019-03-27 最終更新日 2019-05-22 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
6QA3	ERK2 mini-fragment binding 分子名称: Mitogen-activated protein kinase 1, PYRAZOLE, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-18 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
6QA1	ERK2 mini-fragment binding 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, pyridin-2-amine 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-18 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
6QAG	ERK2 mini-fragment binding 分子名称: 1~{H}-1,2,3-triazole, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-19 公開日 2019-03-27 最終更新日 2019-05-22 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
6PU1	Cysteine stabilized hexameric HIV-1 CA in complex with SEC24C peptide 分子名称: CHLORIDE ION, Gag polyprotein, IODIDE ION, ... 著者 Lindenberger, J.J, Kvaratskhelia, M. 登録日 2019-07-16 公開日 2021-01-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Cysteine stabilized hexameric HIV-1 CA in complex with SEC24C peptide To Be Published
6QA4	ERK2 mini-fragment binding 分子名称: 1~{H}-pyridin-2-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-18 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
6QAL	ERK2 mini-fragment binding 分子名称: 1,1-bis(oxidanylidene)thietan-3-ol, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-19 公開日 2019-03-27 最終更新日 2019-05-22 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019

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