PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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2LZE	Ligase 10C 分子名称: ZINC ION, a primordial catalytic fold generated by in vitro evolution 著者 Chao, F, Morelli, A, Haugner, J, Churchfield, L, Hagmann, L, Shi, L, Masterson, L, Sarangi, R, Veglia, G, Seelig, B. 登録日 2012-10-01 公開日 2012-10-24 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structure and dynamics of a primordial catalytic fold generated by in vitro evolution. Nat.Chem.Biol., 9, 2013
8FU3	Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor 分子名称: 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Yu, X, Abeywickrema, P, Bonneux, B, Behera, I, Jacoby, E, Fung, A, Adhikary, S, Bhaumik, A, Carbajo, R.J, Bruyn, S.D, Miller, R, Patrick, A, Pham, Q, Piassek, M, Verheyen, N, Shareef, A, Sutto-Ortiz, P, Ysebaert, N, Vlijmen, H.V, Jonckers, T.H.M, Herschke, F, McLellan, J.S, Decroly, E, Fearns, R, Grosse, S, Roymans, D, Sharma, S, Rigaux, P, Jin, Z. 登録日 2023-01-16 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor. Commun Biol, 6, 2023
8G1L	Lectin domain of Aap (Staphylococcus epidermidis Accumulation Associated Protein) 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, Accumulation associated protein, CALCIUM ION, ... 著者 Maciag, J.J, Herr, A.B. 登録日 2023-02-02 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 Mechanistic basis of staphylococcal interspecies competition for skin colonization To Be Published
4XSE	Complex structure of thymidylate synthase from varicella zoster virus 分子名称: PHOSPHATE ION, Thymidylate synthase 著者 Hew, K. 登録日 2015-01-22 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10, 2015
8DEN	Heme-Free Cytochrome Variant ApoCyt 分子名称: Soluble cytochrome b562 著者 Hoffnagle, A.H, Eng, V.H, Tezcan, F.A. 登録日 2022-06-20 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Computationally Guided Redesign of a Heme-free Cytochrome with Native-like Structure and Stability. Biochemistry, 61, 2022
6OKF	Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C16-crypto Acyl Carrier Protein, AcpP 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... 著者 Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. 登録日 2019-04-12 公開日 2020-04-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
1J79	Molecular Structure of Dihydroorotase: A Paradigm for Catalysis Through the Use of a Binuclear Metal Center 分子名称: N-CARBAMOYL-L-ASPARTATE, OROTIC ACID, ZINC ION, ... 著者 Thoden, J.B, Phillips Jr, G.N, Neal, T.M, Raushel, F.M, Holden, H.M. 登録日 2001-05-16 公開日 2001-06-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center. Biochemistry, 40, 2001
5LP3	Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume. 分子名称: Isoaspartyl dipeptidase 著者 Garcia-Seisdedos, H, Empereur-Mot, C, Elad, N, Levy, E.D. 登録日 2016-08-11 公開日 2017-07-26 最終更新日 2017-08-23 実験手法 ELECTRON MICROSCOPY (10.5 Å) 主引用文献 Proteins evolve on the edge of supramolecular self-assembly. Nature, 548, 2017
8DEL	Trimeric Heme-Free Cytochrome Variant ApoCyt-TriCyt3 分子名称: MAGNESIUM ION, Soluble cytochrome b562, ZINC ION 著者 Hoffnagle, A.M, Eng, V.H, Tezcan, F.A. 登録日 2022-06-20 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Computationally Guided Redesign of a Heme-free Cytochrome with Native-like Structure and Stability. Biochemistry, 61, 2022
4XSD	Complex structure of thymidylate synthase from varicella zoster virus with a dUMP 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase 著者 Hew, K. 登録日 2015-01-22 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. Plos One, 10, 2015
4PYD	MoaC in complex with cPMP crystallized in space group P212121 分子名称: (2R,4AR,5AR,11AR,12AS)-8-AMINO-2-HYDROXY-4A,5A,9,11,11A,12A-HEXAHYDRO[1,3,2]DIOXAPHOSPHININO[4',5':5,6]PYRANO[3,2-G]PTERIDINE-10,12(4H,6H)-DIONE 2-OXIDE, 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... 著者 Tonthat, N.K, Hover, B.M, Yokoyama, K, Schumacher, M.A. 登録日 2014-03-26 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.186 Å) 主引用文献 Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. Proc.Natl.Acad.Sci.USA, 112, 2015
4PYA	MoaC K51A in complex with 3',8-cH2GTP 分子名称: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate, 1,2-ETHANEDIOL, Molybdenum cofactor biosynthesis protein MoaC 著者 Tonthat, N.K, Hover, B.M, Yokoyama, K, Schumacher, M.A. 登録日 2014-03-26 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.789 Å) 主引用文献 Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. Proc.Natl.Acad.Sci.USA, 112, 2015
1IHQ	GLYTM1BZIP: A CHIMERIC PEPTIDE MODEL OF THE N-TERMINUS OF A RAT SHORT ALPHA TROPOMYOSIN WITH THE N-TERMINUS ENCODED BY EXON 1B 分子名称: CHIMERIC PEPTIDE GlyTM1bZip: TROPOMYOSIN ALPHA CHAIN, BRAIN-3 and GENERAL CONTROL PROTEIN GCN4 著者 Greenfield, N.J, Yuang, Y.J, Palm, T, Swapna, G.V, Monleon, D, Montelione, G.T, Hitchcock-Degregori, S.E, Northeast Structural Genomics Consortium (NESG) 登録日 2001-04-19 公開日 2001-10-03 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure and folding dynamics of the N terminus of a rat non-muscle alpha-tropomyosin in an engineered chimeric protein. J.Mol.Biol., 312, 2001
8DIJ	NMR Structure of Streptococcal Protein GB1 Backbone Modified Variant: beta-ACPC24, beta-3-Lys28, beta-3-Lys31, beta-ACPC35 分子名称: Immunoglobulin G-binding protein G 著者 Rao, S.R, Reinert, Z.E. 登録日 2022-06-29 公開日 2022-11-23 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States. Pept Sci (Hoboken), 115, 2023
6PIG	V. cholerae TniQ-Cascade complex, closed conformation 分子名称: RNA (60-MER), TniQ monomer 1, TniQ monomer 2, ... 著者 Halpin-Healy, T, Klompe, S, Sternberg, S.H. 登録日 2019-06-26 公開日 2019-10-02 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system. Nature, 577, 2020
6P6B	CS-Rosetta Model of PEA-15 Death Effector Domain 分子名称: Astrocytic phosphoprotein PEA-15 著者 Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S. 登録日 2019-06-03 公開日 2019-07-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions. Int J Mol Sci, 20, 2019
6PF7	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)benzoic acid 分子名称: 2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.795 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6P6C	CS-Rosetta Model of PEA-15 Death Effector Domain in the Complex with ERK2 分子名称: Astrocytic phosphoprotein PEA-15 著者 Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S. 登録日 2019-06-03 公開日 2019-07-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions. Int J Mol Sci, 20, 2019
2M7C	Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple 分子名称: Trp-Cage mini-protein 著者 Byrne, A, Andersen, N.H, Kier, B.L. 登録日 2013-04-18 公開日 2013-12-25 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple. RSC Adv, 2013, 2013
2LUF	Retro Trp-cage peptide 分子名称: Retro Trp-cage peptide 著者 Bathula, S, Sklenar, V, Zidek, L, Vondrasek, J, Vymetal, J. 登録日 2012-06-13 公開日 2013-06-26 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 All ingredients still do not guarantee a taste. Can we predict a fold of retro peptides or proteins? The retro Trp-cage model case. To be Published
6PFB	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 3-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)propanoic acid. 分子名称: 3-[2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)phenyl]propanoic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.089 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PFA	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-((4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)methyl)benzoic acid. 分子名称: 2-[({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)methyl]benzoic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PFI	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 3-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-(carboxymethyl)benzoic acid. 分子名称: 3-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-(carboxymethyl)benzoic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... 著者 Czyzyk, D.J, Anderson, K.S, Jorgensen, W.L, Valhondo, M. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
6PIJ	Target DNA-bound V. cholerae TniQ-Cascade complex, closed conformation 分子名称: Non-targeting strand ssDNA, Targeting strand ssDNA, TniQ monomer 2, ... 著者 Halpin-Healy, T, Klompe, S, Sternberg, S.H. 登録日 2019-06-26 公開日 2019-10-02 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system. Nature, 577, 2020
6PF4	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase, [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)phenyl]acetic acid 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.854 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019

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