PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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7ZRY	Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Isoform of Lysine-specific histone demethylase 1A, REST corepressor 1 著者 Caroli, J, Mattevi, A. 登録日 2022-05-06 公開日 2022-08-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. Iscience, 25, 2022
6FWB	Crystal structure of Mat2A at 1.79 Angstron resolution 分子名称: GLYCEROL, S-adenosylmethionine synthase isoform type-2, SODIUM ION, ... 著者 Zhou, A, Wei, Z, Bai, J, Wang, H. 登録日 2018-03-06 公開日 2019-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes. Ebiomedicine, 39, 2019
8J07	96nm repeat of human respiratory doublet microtubule and associated axonemal complexes 分子名称: ACTA2, Axonemal dynein light intermediate polypeptide 1, Calaxin, ... 著者 Gui, M, Brown, A. 登録日 2023-04-09 公開日 2023-07-26 最終更新日 2023-08-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Axonemal structures reveal mechanoregulatory and disease mechanisms. Nature, 618, 2023
8A6L	Human 4F2hc-LAT2 heterodimeric amino acid transporter in complex with anticalin D11vs 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2hc cell-surface antigen heavy chain, Anticalin D11vs, ... 著者 Jeckelmann, J.M, Fotiadis, D. 登録日 2022-06-18 公開日 2022-11-09 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM. Sci Rep, 12, 2022
7ZN7	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-20 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
7ZNN	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-21 公開日 2022-11-09 最終更新日 2023-03-15 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
8IXB	GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
8IXE	GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
8IXD	GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
8IXG	GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
8IXA	GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin non-seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
8IXF	GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ... 著者 Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y. 登録日 2023-03-31 公開日 2023-08-16 最終更新日 2023-10-25 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules. Acta Biochim.Biophys.Sin., 55, 2023
6DFO	Crystal structure of human GRP78 in complex with 8-bromoadenosine 分子名称: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-bromoadenosine To be Published
6DV1	Crystal structure of the alpha-E-catenin actin-binding domain 分子名称: BROMIDE ION, Catenin alpha-1, SULFATE ION 著者 Ishiyama, N, Ikura, M. 登録日 2018-06-22 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Force-dependent allostery of the alpha-catenin actin-binding domain controls adherens junction dynamics and functions. Nat Commun, 9, 2018
6DWK	SAMHD1 Bound to Fludarabine-TP in the Catalytic Pocket 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, ... 著者 Knecht, K.M, Buzovetsky, O, Schneider, C, Thomas, D, Srikanth, V, Kaderali, L, Tofoleanu, F, Reiss, K, Ferreiros, N, Geisslinger, G, Batista, V.S, Ji, X, Cinatl, J, Keppler, O.T, Xiong, Y. 登録日 2018-06-26 公開日 2018-10-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8JMX	The crystal structure of human aurka kinase domain in complex with AURKA-A2 分子名称: 5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-oxidanyl-benzaldehyde, Aurora kinase A 著者 Zhu, C.J, Zhang, Z.M. 登録日 2023-06-05 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.95020175 Å) 主引用文献 Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently. Chem.Commun.(Camb.), 59, 2023
6G0H	BRD4 (BD1) in complex with APSC-derived ligands (e.g. SSLH01 a sulfasalazine derivate) 分子名称: 1,2-ETHANEDIOL, 4-azanyl-2-oxidanyl-5-[(~{E})-[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid, Bromodomain-containing protein 4, ... 著者 Humbeck, L, Pretzel, J. 登録日 2018-03-18 公開日 2020-01-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.907 Å) 主引用文献 Discovery of an Unexpected Similarity in Ligand Binding Between BRD4 and PPARgamma Chemrxiv, 2019
6GBM	Solution structure of FUS-RRM bound to stem-loop RNA 分子名称: RNA (5'-R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP*C)-3'), RNA-binding protein FUS 著者 Loughlin, F.E, Allain, F.H.-T. 登録日 2018-04-15 公開日 2019-02-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity. Mol. Cell, 73, 2019
8JDK	Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2023-05-14 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.26 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
8JDM	Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2023-05-14 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
6FO1	Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. 分子名称: ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... 著者 Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. 登録日 2018-02-05 公開日 2018-04-04 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. Nat Commun, 9, 2018
8JDL	Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2023-05-14 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.42 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
6FY5	Crystal structure of the macro domain of human macroh2a2 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Core histone macro-H2A.2 著者 Hothorn, M. 登録日 2018-03-10 公開日 2018-04-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms. EMBO Rep., 19, 2018
8JDJ	Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU) 分子名称: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... 著者 Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. 登録日 2023-05-14 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell, 186, 2023
6FSY	Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand 分子名称: 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, Bromodomain-containing protein 4 著者 Filippakopoulos, P, Picaud, S, Conway, S.J, Pike, A.C.W, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Structural Genomics Consortium (SGC) 登録日 2018-02-20 公開日 2018-04-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg.Med.Chem., 26, 2018

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