PDB: 45459 件ウェブページステータス検索Chemie searchBIRD

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6TBD	Crystal structure of the SVS_A2 protein from ancestral sequence reconstruction at 2.30 A resolution 分子名称: Design protein SVS_A2 著者 Rudraraju, R, Schnell, R, Schneider, G. 登録日 2019-11-01 公開日 2020-10-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase. J.Am.Chem.Soc., 143, 2021
6TPD	Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity 分子名称: 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one, Tyrosine-protein kinase JAK2 著者 Hansen, B.B, Jepsen, T.J, Larsen, M, Sindet, R, Vifian, T, Burhardt, M.N, Larsen, J, Seitzberg, J.G, Carnerup, M.A, Jerre, A, Moelck, C, Rai, S, Nasipireddy, V.R, Ritzen, A. 登録日 2019-12-13 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J.Med.Chem., 63, 2020
5LTX	LIGAND BINDING DOMAIN OF PSEUDOMONAS AERUGINOSA PAO1 AMINO ACID CHEMORECEPTOR PCTA IN COMPLEX WITH L-MET 分子名称: ACETATE ION, Chemotaxis protein, FORMIC ACID, ... 著者 Gavira, J.A, Rico-Gimenez, M, Ortega, A, Conejero-Muriel, M, Zhulin, I, Krell, T. 登録日 2016-09-07 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 How Bacterial Chemoreceptors Evolve Novel Ligand Specificities Mbio, 2020
5M3Q	Crystal structure of Tif6 from Chaetomium thermophilum 分子名称: Eukaryotic translation initiation factor 6, GLYCEROL, SULFATE ION 著者 Ahmed, Y.L, Calvino, F.R, Sinning, I. 登録日 2016-10-17 公開日 2016-11-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Interaction network of the ribosome assembly machinery from a eukaryotic thermophile. Protein Sci., 26, 2017
6TW3	HumRadA2 in complex with Naphthyl-HPA fragment-peptide chimera 分子名称: (2~{S})-1-[(2~{S})-2-[(3-azanylnaphthalen-2-yl)carbonylamino]-3-(1~{H}-imidazol-4-yl)propanoyl]-~{N}-[(2~{S})-1-azanyl-1-oxidanylidene-propan-2-yl]pyrrolidine-2-carboxamide, DNA repair and recombination protein RadA, PHOSPHATE ION 著者 Marsh, M.E, Fischer, G, Scott, D.E, Coyne, A.G, Skidmore, J, Abell, C, Hyvonen, M. 登録日 2020-01-12 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.352 Å) 主引用文献 A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol, 28, 2021
5LWY	Revised crystal structure of the human adiponectin receptor 2 in complex with a C18 free fatty acid 分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adiponectin receptor protein 2, GLYCEROL, ... 著者 Leyrat, C, Vasiliauskaite-Brooks, I, Granier, S. 登録日 2016-09-19 公開日 2017-03-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural insights into adiponectin receptors suggest ceramidase activity. Nature, 6, 2017
5ACO	Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 ENVELOPE GLYCOPROTEIN, ... 著者 Lee, J.H, Ward, A.B. 登録日 2015-08-17 公開日 2015-09-30 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy. Structure, 23, 2015
6I7R	Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the P43212 form 分子名称: Elongin-B, Elongin-C, Endothelial PAS domain-containing protein 1, ... 著者 Chowdhury, R, Aguilera, L.S, Schofield, C.J. 登録日 2018-11-17 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 HIF-2alpha-pVHL-elongin B-elongin C complex To Be Published
6I95	R2-like ligand-binding oxidase G68L mutant with anaerobically reconstituted Mn/Fe cofactor 分子名称: FE (II) ION, MANGANESE (II) ION, OCTANOIC ACID (CAPRYLIC ACID), ... 著者 Griese, J.J, Hogbom, M. 登録日 2018-11-22 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.646 Å) 主引用文献 Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins. J.Biol.Chem., 294, 2019
5LVM	Human PDK1 Kinase Domain in Complex with Adenine Bound to the ATP-Binding Site 分子名称: 3-phosphoinositide-dependent protein kinase 1, ADENINE, DITHIANE DIOL 著者 Schulze, J.O, Saladino, G, Busschots, K, Neimanis, S, Suess, E, Odadzic, D, Zeuzem, S, Hindie, V, Herbrand, A.K, Lisa, M.N, Alzari, P.M, Gervasio, F.L, Biondi, R.M. 登録日 2016-09-14 公開日 2016-10-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol, 23, 2016
7CSW	Pseudomonas aeruginosa antitoxin HigA with pa2440 promoter 分子名称: HTH cro/C1-type domain-containing protein, pa2440 著者 Song, Y.J, Luo, G.H, Bao, R. 登録日 2020-08-17 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environ.Microbiol., 23, 2021
5HJP	Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease 分子名称: 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, DI(HYDROXYETHYL)ETHER, Oxysterols receptor LXR-beta, ... 著者 Parthasarathy, G, Klein, D. 登録日 2016-01-13 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59, 2016
6U1G	Thermus thermophilus D-alanine-D-alanine ligase in complex with ATP, D-alanine-D-alanine, Mg2+ and Cs+ 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, D-ALANINE, ... 著者 Pederick, J.L, Bruning, J.B. 登録日 2019-08-15 公開日 2020-05-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
4YMV	Crystal structure of an amino acid ABC transporter with ATPs 分子名称: ABC-type amino acid transport system, permease component, ABC-type polar amino acid transport system, ... 著者 Ge, J, Yu, J, Yang, M. 登録日 2015-03-07 公開日 2015-04-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.003 Å) 主引用文献 Structural basis for substrate specificity of an amino acid ABC transporter Proc.Natl.Acad.Sci.USA, 112, 2015
6TWZ	14-3-3 sigma complexed with a phosphorylated 16E6 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D(-)-TARTARIC ACID, ... 著者 Gogl, G, Cousido-Siah, A, Sluchanko, N.N, Trave, G. 登録日 2020-01-13 公開日 2020-05-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
6U3N	LS2.8/3.15 - DQ2-P.fluor-alpha1a complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ... 著者 Petersen, J, Rossjohn, J. 登録日 2019-08-22 公開日 2019-12-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease. Nat.Struct.Mol.Biol., 27, 2020
6I94	R2-like ligand-binding oxidase G68L mutant with non-activated Mn/Mn cofactor (after aerobic reconstitution with Mn and Fe) 分子名称: MANGANESE (II) ION, OCTANOIC ACID (CAPRYLIC ACID), Ribonucleotide reductase small subunit 著者 Griese, J.J, Hogbom, M. 登録日 2018-11-22 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins. J.Biol.Chem., 294, 2019
5NTY	Structure of non-fluorescent human plasma RBP4 分子名称: CHLORIDE ION, PALMITIC ACID, Retinol-binding protein 4 著者 Perduca, M, Monaco, H.L, Galliano, M. 登録日 2017-04-28 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein. Biochim. Biophys. Acta, 1863, 2018
6IPB	Crystal Structure of the Cofactor-binding Domain of the Human Phase II Drug Metabolism Enzyme UGT2B15 分子名称: GLYCEROL, L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B15 著者 Zhang, L, Xie, W, Wang, C. 登録日 2018-11-02 公開日 2020-01-15 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem. Pharmacol., 172, 2019
6U1H	Thermus thermophilus D-alanine-D-alanine ligase in complex with ADP, phosphate, Mg2+ and K+ 分子名称: ADENOSINE-5'-DIPHOSPHATE, D-alanine--D-alanine ligase, MAGNESIUM ION, ... 著者 Pederick, J.L, Bruning, J.B. 登録日 2019-08-15 公開日 2020-05-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations. J.Biol.Chem., 295, 2020
5OD1	Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue 分子名称: GLYCEROL, MID1sc10, ZINC ION, ... 著者 Mittl, P.R.E, Studer, S, Hansen, D.A, Hilvert, D. 登録日 2017-07-04 公開日 2018-12-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science, 362, 2018
6UA3	Human Mcl-1 in complex with a modified Bim BH3 peptide 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide 著者 Mandal, T, Grant, R.A, Keating, A.E. 登録日 2019-09-10 公開日 2020-09-16 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response. To Be Published
5HUN	The crystal structure of neuraminidase from A/gyrfalcon/Washington/41088-6/2014 influenza virus 分子名称: CALCIUM ION, Neuraminidase 著者 Yang, H, Carney, P.J, Guo, Z, Chang, J.C, Stevens, J. 登録日 2016-01-27 公開日 2016-04-13 最終更新日 2016-06-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses. J.Virol., 90, 2016
5H9E	Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. 分子名称: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... 著者 Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. 登録日 2015-12-28 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
5NWE	Complex of H275Y mutant variant of neuraminidase from H1N1 influenza virus with oseltamivir 分子名称: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pachl, P, Pokorna, J. 登録日 2017-05-05 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus. Viruses, 10, 2018

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