4A3L
| RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid and soaked with AMPCPP | 分子名称: | 5'-D(*AP*AP*GP*TP*AP*CP*TP)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*TP *TP*TP*CP*CP*BRU*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*AP*CP*CP*AP*GP*GP*AP)-3', ... | 著者 | Cheung, A.C.M, Sainsbury, S, Cramer, P. | 登録日 | 2011-09-30 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
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7OK0
| Cryo-EM structure of the Sulfolobus acidocaldarius RNA polymerase at 2.88 A | 分子名称: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | 著者 | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | 登録日 | 2021-05-17 | 公開日 | 2021-08-25 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of RNA polymerase inhibition by viral and host factors. Nat Commun, 12, 2021
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7NZM
| Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Yan, Y, Hardwick, S, Ron, D. | 登録日 | 2021-03-24 | 公開日 | 2021-09-29 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | 主引用文献 | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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4A3G
| RNA Polymerase II initial transcribing complex with a 2nt DNA-RNA hybrid | 分子名称: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | 著者 | Cheung, A.C.M, Sainsbury, S, Cramer, P. | 登録日 | 2011-09-30 | 公開日 | 2012-02-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
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4A3F
| RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid and soaked with AMPCPP | 分子名称: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*DTP *TP*TP*CP*C BRU*GP*GP*TP*CP*AP*TP*T)-3', DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, ... | 著者 | Cheung, A.C.M, Sainsbury, S, Cramer, P. | 登録日 | 2011-09-30 | 公開日 | 2011-12-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of initial RNA polymerase II transcription. EMBO J., 30, 2011
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7D45
| eIF2B-eIF2(aP), aP1 complex | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Kashiwagi, K, Ito, T. | 登録日 | 2020-09-22 | 公開日 | 2020-12-09 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81, 2021
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7D44
| eIF2B-eIF2(aP), aP2 complex | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | 著者 | Kashiwagi, K, Ito, T. | 登録日 | 2020-09-22 | 公開日 | 2020-12-09 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81, 2021
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7EDX
| p53-bound TFIID-based core PIC on HDM2 promoter | 分子名称: | DNA (84-mer), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | 登録日 | 2021-03-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGB
| TFIID-based holo PIC on SCP promoter | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-05 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EG7
| TFIID-based core PIC on SCP promoter | 分子名称: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EG9
| TFIID-based intermediate PIC on SCP promoter | 分子名称: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGA
| TFIID-based intermediate PIC on PUMA promoter | 分子名称: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EG8
| TFIID-based core PIC on PUMA promoter | 分子名称: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7EGC
| p53-bound TFIID-based holo PIC on HDM2 promoter | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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7ENA
| TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | 登録日 | 2021-04-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | 主引用文献 | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7ENC
| TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | 登録日 | 2021-04-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (4.13 Å) | 主引用文献 | Structures of the human Mediator and Mediator-bound preinitiation complex. Science, 372, 2021
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7D43
| eIF2B-eIF2(aP), aPg complex | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | 著者 | Kashiwagi, K, Ito, T. | 登録日 | 2020-09-22 | 公開日 | 2020-12-09 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol.Cell, 81, 2021
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7F4G
| Structure of RPAP2-bound RNA polymerase II | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Chen, X, Qi, Y, Wang, X, Li, J, Zhao, D, Xu, Y. | 登録日 | 2021-06-18 | 公開日 | 2021-07-07 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Rep, 39, 2022
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7D4I
| Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1 (State F) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | 登録日 | 2020-09-24 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structure of 90S small ribosomal precursors complex with Dhr1 To Be Published
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7D63
| Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | 登録日 | 2020-09-29 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (12.3 Å) | 主引用文献 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state C) To Be Published
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7D5S
| Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S12, ... | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | 登録日 | 2020-09-28 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2) To Be Published
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7D5T
| Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 18S rRNA, 40S ribosomal protein S1-A, ... | 著者 | Du, Y, Zhang, J, An, W, Ye, K. | 登録日 | 2020-09-28 | 公開日 | 2021-10-06 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1) To Be Published
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7F67
| eIF2B-SFSV NSs-2-eIF2 | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | 著者 | Kashiwagi, K, Ito, T. | 登録日 | 2021-06-24 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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7F66
| eIF2B-SFSV NSs-1-eIF2 | 分子名称: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, Non-structural protein NS-S, ... | 著者 | Kashiwagi, K, Ito, T. | 登録日 | 2021-06-24 | 公開日 | 2021-12-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | eIF2B-capturing viral protein NSs suppresses the integrated stress response. Nat Commun, 12, 2021
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8OEU
| Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Chen, Y, Kokic, G, Dienemann, C, Dybkov, O, Urlaub, H, Cramer, P. | 登録日 | 2023-03-13 | 公開日 | 2023-10-18 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Structure of the transcribing RNA polymerase II-Elongin complex. Nat.Struct.Mol.Biol., 30, 2023
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