PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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6YLU	14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, BLNKpT152, MAGNESIUM ION 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-04-07 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure J.Struct.Biol., 2020
6R5L	Fragment AZ-006 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-[[(2~{S})-1-azanylpropan-2-yl]amino]-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-03-25 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM5	Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RJQ	Fragment AZ-006 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-[[(2~{S})-1-azanylpropan-2-yl]amino]-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, TAZpS89 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C, Patel, J. 登録日 2019-04-29 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RP6	Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CALCIUM ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-05-14 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.885 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6ZC9	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. 登録日 2020-06-10 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.89895988 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus 分子名称: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL 著者 Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
7OBC	Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-21 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-11-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
4FR3	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H 分子名称: (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... 著者 Ottmann, C, Anders, C, Schumacher, B. 登録日 2012-06-26 公開日 2013-05-08 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
6S40	Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites 分子名称: 14-3-3 protein sigma, 4-chloranyl-1-benzothiophene-2-carboximidamide, CALCIUM ION, ... 著者 Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. 登録日 2019-06-26 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
3UBW	Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen 分子名称: (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ... 著者 Molzan, M, Weyand, M, Rose, R, Ottmann, C. 登録日 2011-10-25 公開日 2012-01-25 最終更新日 2012-02-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
6F08	14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1) 分子名称: 14-3-3 protein zeta/delta, PENTAETHYLENE GLYCOL, Son of sevenless homolog 1 著者 Ballone, A, Centorrino, F, Ottmann, C, Guo, S, Leysen, S. 登録日 2017-11-17 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural characterization of 14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1). J. Struct. Biol., 202, 2018
7OQW	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178 分子名称: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), MAGNESIUM ION, ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-06-04 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
6SLV	Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 4-(methylamino)-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. 登録日 2019-08-20 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
3SML	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin A aglycone 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Fusicoccin A aglycone, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
7NIX	14-3-3 sigma with AS160 binding site pT642 分子名称: 14-3-3 protein sigma, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, MAGNESIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-02-14 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1011 分子名称: 14-3-3 protein sigma, 4-(2-phenylimidazol-1-yl)naphthalene-1-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8EQH	The crystal structure of 14-3-3 Beta containing 3-nitrotyrosine at position Y213 分子名称: 14-3-3 protein beta/alpha 著者 Zhu, P, Cooley, R.B. 登録日 2022-10-07 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation. Protein Sci., 32, 2023
6G8P	14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. 登録日 2018-04-09 公開日 2019-04-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
7NIG	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1008 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6QZS	14-3-3 sigma in complex with FOXO1 pS256 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... 著者 Ottmann, C, Wolter, M, Lau, R.A. 登録日 2019-03-12 公開日 2019-07-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
4FL5	Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Schumacher, B, Ottmann, C. 登録日 2012-06-14 公開日 2013-12-11 最終更新日 2017-06-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J., 29, 2015
3P1O	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
6Y58	Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (LBD) phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Related Receptor gamma phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Sijbesma, E, Leijten-van de Gevel, I.A, Ottmann, C. 登録日 2020-02-25 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.904 Å) 主引用文献 Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020

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