PDB: 974 件ウェブページステータス検索Chemie searchBIRD

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5YW9	Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A) 分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Chen, L, Wu, J.X. 登録日 2017-11-29 公開日 2018-05-02 最終更新日 2018-06-13 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YW8	Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A) 分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Chen, L, Wu, J.X. 登録日 2017-11-29 公開日 2018-05-02 最終更新日 2018-06-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YT3	Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase kinase 1, isoform CRA_d, ... 著者 Nakae, S, Doko, K, Tada, T, Shirai, T. 登録日 2017-11-16 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant To Be Published
5YKG	Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A) 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... 著者 Chen, L, Wu, J.X. 登録日 2017-10-14 公開日 2018-04-18 最終更新日 2018-06-13 実験手法 ELECTRON MICROSCOPY (4.57 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YKF	Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A) 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... 著者 Chen, L, Wu, J.X. 登録日 2017-10-14 公開日 2018-04-18 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.33 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YKE	Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A) 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11 著者 Chen, L, Wu, J.X. 登録日 2017-10-14 公開日 2018-04-18 最終更新日 2018-06-13 実験手法 ELECTRON MICROSCOPY (4.11 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
5YI4	Solution Structure of the DISC1/Ndel1 complex 分子名称: Disrupted in schizophrenia 1 homolog,Nuclear distribution protein nudE-like 1 著者 Ye, F, Yu, C, Yu, C, Zhang, M. 登録日 2017-10-02 公開日 2017-11-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. Neuron, 96, 2017
5XYY	The structure of p38 alpha in complex with a triazol inhibitor 分子名称: 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol, Mitogen-activated protein kinase 14 著者 Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. 登録日 2017-07-11 公開日 2018-01-17 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60, 2017
5XYX	The structure of p38 alpha in complex with a triazol inhibitor 分子名称: Mitogen-activated protein kinase 14, N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine 著者 Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. 登録日 2017-07-11 公開日 2018-01-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60, 2017
5WVC	Structure of the CARD-CARD disk 分子名称: Apoptotic protease-activating factor 1, Caspase, IODIDE ION 著者 Lin, S.C, Lo, Y.C, Su, T.W. 登録日 2016-12-24 公開日 2017-04-19 実験手法 X-RAY DIFFRACTION (2.993 Å) 主引用文献 Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome. Structure, 25, 2017
5WUA	Structure of a Pancreatic ATP-sensitive Potassium Channel 分子名称: ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1 著者 Li, N, Wu, J.-X, Chen, L, Gao, N. 登録日 2016-12-16 公開日 2017-01-25 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Structure of a Pancreatic ATP-Sensitive Potassium Channel Cell, 168, 2017
5WP1	Complex of ERK2 with 5,7-dihydroxychromone 分子名称: 5,7-dihydroxy-4H-1-benzopyran-4-one, BENZOIC ACID, Mitogen-activated protein kinase 1, ... 著者 Kurinov, I, Malakhova, M. 登録日 2017-08-03 公開日 2018-08-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers To Be Published
5WJJ	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors 分子名称: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide 著者 Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. 登録日 2017-07-23 公開日 2018-01-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
5W4Q	Structure of the R18A/E28A mutant of the HIV-1 capsid protein 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION 著者 Gres, A.T, Kirby, K.A, Sarafianos, S.G. 登録日 2017-06-12 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.285 Å) 主引用文献 Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
5W4P	Structure of the E28A mutant of the HIV-1 capsid protein 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION 著者 Gres, A.T, Kirby, K.A, Sarafianos, S.G. 登録日 2017-06-12 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
5W4O	Structure of the R18A mutant of the HIV-1 capsid protein 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION 著者 Gres, A.T, Kirby, K.A, Sarafianos, S.G. 登録日 2017-06-12 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.093 Å) 主引用文献 Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket. MBio, 10, 2019
5W1F	Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin 分子名称: CALCIUM ION, NICKEL (II) ION, Protein S100-A8, ... 著者 Nakashige, T.G, Drennan, C.L, Nolan, E.M. 登録日 2017-06-03 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Nickel Sequestration by the Host-Defense Protein Human Calprotectin. J. Am. Chem. Soc., 139, 2017
5VVT	Structural Investigations of the Substrate Specificity of Human O-GlcNAcase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ELK1 peptide, Protein O-GlcNAcase 著者 Li, B, Jiang, J, Li, H, Hu, C.-W. 登録日 2017-05-20 公開日 2017-09-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nat Commun, 8, 2017
5V62	Phospho-ERK2 bound to bivalent inhibitor SBP3 分子名称: 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ... 著者 Lechtenberg, B.C, Riedl, S.J. 登録日 2017-03-15 公開日 2017-07-26 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
5V61	Phospho-ERK2 bound to bivalent inhibitor SBP2 分子名称: 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ... 著者 Lechtenberg, B.C, Riedl, S.J. 登録日 2017-03-15 公開日 2017-07-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
5V60	Phospho-ERK2 bound to AMP-PCP 分子名称: GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ... 著者 Lechtenberg, B.C, Riedl, S.J. 登録日 2017-03-15 公開日 2017-07-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
5UPW	CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations 分子名称: Gag polyprotein 著者 Perilla, J.R. 登録日 2017-02-04 公開日 2017-03-01 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 CryoEM Structure Refinement by Integrating NMR Chemical Shifts with Molecular Dynamics Simulations. J Phys Chem B, 121, 2017
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION 分子名称: Mitogen-activated protein kinase 14 著者 CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. 登録日 2017-01-31 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
5UMO	STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE 分子名称: Mitogen-activated protein kinase 1, SULFATE ION 著者 CHLEBOWICZ, J, ZHANG, F, GOLDSMITH, E.J. 登録日 2017-01-27 公開日 2017-03-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature, 367, 1994
5U6I	Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity 分子名称: 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION 著者 Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W. 登録日 2016-12-08 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J. Med. Chem., 60, 2017

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