6WNS
| |
3ILS
| The Thioesterase Domain from PksA | 分子名称: | Aflatoxin biosynthesis polyketide synthase | 著者 | Korman, T.P. | 登録日 | 2009-08-07 | 公開日 | 2010-04-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
7RIG
| Structure of ACLY-D1026A-substrates | 分子名称: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | 著者 | Wei, X, Marmorstein, R. | 登録日 | 2021-07-19 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
|
|
7RKZ
| |
7RMP
| Structure of ACLY D1026A - substrates-asym | 分子名称: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | 著者 | Wei, X, Marmorstein, R. | 登録日 | 2021-07-28 | 公開日 | 2023-05-10 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
|
|
2KG6
| Solution Structure of the acetyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, THIOACETIC ACID S-{2-[3-(2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTYRYLAMINO)-PROPIONYLAMINO]-ETHYL} ESTER | 著者 | Crump, M.P, Evans, S.E, Eliza, P, Christopher, W. | 登録日 | 2009-03-06 | 公開日 | 2009-04-14 | 最終更新日 | 2021-10-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J.Mol.Biol., 389, 2009
|
|
6FIJ
| Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | 著者 | Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T. | 登録日 | 2018-01-18 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases. Nat. Chem. Biol., 14, 2018
|
|
8EE0
| KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2 | 分子名称: | 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase | 著者 | Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C. | 登録日 | 2022-09-06 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry, 62, 2023
|
|
7W58
| Crystal structure of acyl-carrier protein synthase from Mycobacterium smegmatis | 分子名称: | 1,2-ETHANEDIOL, 4'-phosphopantetheinyl transferase, NICKEL (II) ION | 著者 | Yadav, S, Bhatia, I, Biswal, B.K. | 登録日 | 2021-11-29 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Identification, structure determination and analysis of Mycobacterium smegmatis acyl-carrier protein synthase (AcpS) crystallized serendipitously. Acta Crystallogr.,Sect.F, 78, 2022
|
|
7M7E
| 6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2 | 分子名称: | 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ... | 著者 | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | 登録日 | 2021-03-28 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
|
|
4IMO
| Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069 | 分子名称: | (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}hept-5-enoic acid, Lipocalin-type prostaglandin-D synthase, THIOCYANATE ION | 著者 | Lim, S.M, Chen, D, Teo, H, Roos, A, Nyman, T, Tresaugues, L, Pervushin, K, Nordlund, P. | 登録日 | 2013-01-03 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase. J.Lipid Res., 54, 2013
|
|
7M7H
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1' | 分子名称: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | 著者 | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | 登録日 | 2021-03-28 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
|
|
7M7F
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1 | 分子名称: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | 著者 | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | 登録日 | 2021-03-28 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
|
|
7M7G
| 6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2 | 分子名称: | 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ... | 著者 | Cogan, D.P, Zhang, K, Chiu, W, Khosla, C. | 登録日 | 2021-03-28 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science, 374, 2021
|
|
6C9U
| Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | 分子名称: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | 著者 | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | 登録日 | 2018-01-28 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J. Am. Chem. Soc., 140, 2018
|
|
3QMN
| Crystal Structure of 4'-Phosphopantetheinyl Transferase AcpS from Vibrio cholerae O1 biovar eltor | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | 著者 | Kim, Y, Halavaty, A.S, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-02-04 | 公開日 | 2011-03-02 | 最終更新日 | 2012-12-05 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria. Acta Crystallogr.,Sect.D, 68, 2012
|
|
7CQT
| Crystal structure of Brassica juncea HMG-CoA synthase 1 mutant - S359A in complex with acetyl-CoA | 分子名称: | 3-hydroxy-3-methylglutaryl coenzyme A synthase, ACETYL COENZYME *A, ADENOSINE-3'-5'-DIPHOSPHATE | 著者 | Liao, P, Hu, M, Kong, G.K.W, Hao, Q, Chye, M.L. | 登録日 | 2020-08-11 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Overexpression and Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA Synthase Affect Central Metabolic Pathways in Tobacco. Plant Cell.Physiol., 62, 2021
|
|
7DRJ
| Crystal structure of phosphatidylglycerol phosphate synthase in complex with phosphatidylglycerol phosphate | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,4-BUTANEDIOL, ACETIC ACID, ... | 著者 | Yang, B.W, Liu, Z.F. | 登録日 | 2020-12-28 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface. Curr Res Struct Biol, 3, 2021
|
|
7DRK
| Crystal structure of phosphatidylglycerol phosphate synthase in complex with cytidine diphosphate-diacylglycerol | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,4-BUTANEDIOL, 5'-O-[(R)-{[(S)-{(2R)-2,3-bis[(9E)-octadec-9-enoyloxy]propoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine, ... | 著者 | Yang, B.W, Liu, Z.F. | 登録日 | 2020-12-28 | 公開日 | 2021-12-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface. Curr Res Struct Biol, 3, 2021
|
|
8G1E
| Structure of ACLY-D1026A-products-asym | 分子名称: | (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Wei, X, Marmorstein, R. | 登録日 | 2023-02-02 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
|
|
8G5D
| |
8G1F
| Structure of ACLY-D1026A-products | 分子名称: | (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Wei, X, Marmorstein, R. | 登録日 | 2023-02-02 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
|
|
8G5C
| |
3R44
| |
3HKK
| |