PDB: 621 件ウェブページステータス検索Chemie searchBIRD

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8BXS	Fragment-linked stabilizer for ERa - 14-3-3 interaction (1075293) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-(4-chloranylphenoxy)oxane-4-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (AZ210) 分子名称: 14-3-3 protein sigma, 4-[(2~{S})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWZ	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074393) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-ethanoylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXI	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-08 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYD	fragment-linked stabilizer for ERa - 14-3-3 interactions (1075288) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclopentane-1-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BWX	Fragment-linked stabilizer for 14-3-3 and ERa (1075298) 分子名称: 14-3-3 protein sigma, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ERalpha peptide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYF	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047455) 分子名称: 14-3-3 protein sigma, PHE-PRO-ALA-TPO-VAL, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-chloranylphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYC	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075316) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C0K	fragment-linked stabilizer for ERa - 14-3-3 interaction (1075302) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-17 公開日 2023-08-02 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX3	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074372) 分子名称: 14-3-3 protein sigma, 2-(4-bromanylphenoxy)-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-methyl-propanamide, ERalpha peptide, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXN	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074399) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-4-phenoxy-oxane-4-carboxamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYY	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074395) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-[(4-chlorophenyl)amino]-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C04	Co-soaked stabilizers for ERa - 14-3-3 interaction (884_AZ354) 分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-15 公開日 2023-08-02 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C4F	Small molecule amidine soak in 14-3-3/ERa (AZ037) 分子名称: 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2023-01-03 公開日 2023-08-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BX0	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074388) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-2-(4-methoxyphenoxy)-2-methyl-propanamide 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-07 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BXM	fragment-linked stabilizer for ERa - 14-3-3 interaction (1074397) 分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-12-09 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BYG	fragment-linked stabilizer for ERa - 14-3-3 interaction (1047648) 分子名称: 14-3-3 protein sigma, ERalpha peptide, ~{N}-[2-[(2-carbamimidoyl-1-benzothiophen-4-yl)-methyl-amino]ethyl]-2-(4-chloranylphenoxy)-~{N},2-dimethyl-propanamide 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-12 公開日 2023-08-30 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8BZ9	single soak stabilizer for ERa - 14-3-3 interaction (AZ354) 分子名称: 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-30 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
8C2E	Structure of 14-3-3 sigma delta C with electrophilic peptide 4IEA-5 分子名称: 14-3-3 protein sigma, ARG-SER-ALA-SEP-CYS-PRO-SER-LEU, CHLORIDE ION, ... 著者 van den Oetelaar, M.C.M, Ottmann, C. 登録日 2022-12-22 公開日 2023-11-01 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
8C2F	Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5 分子名称: 14-3-3 protein sigma, ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN, CHLORIDE ION, ... 著者 van den Oetelaar, M.C.M, Ottmann, C. 登録日 2022-12-22 公開日 2023-11-01 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A simple method for developing lysine targeted covalent protein reagents. Nat Commun, 14, 2023
6QZS	14-3-3 sigma in complex with FOXO1 pS256 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... 著者 Ottmann, C, Wolter, M, Lau, R.A. 登録日 2019-03-12 公開日 2019-07-31 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
8C40	14-3-3sigma bound to PKA-responsive ERa phosphopeptide 分子名称: 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8C43	Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
8BZF	FC-J acetonide stabilizer of 14-3-3 and ERalpha 分子名称: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin J-acetonide, ... 著者 Visser, E.J, Ottmann, C. 登録日 2022-12-14 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8C42	Ternary structure of 14-3-3sigma, PKA-responsive ERa phosphopeptide and Fusicoccin-A 分子名称: 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen receptor, ... 著者 Somsen, B.A, Ottmann, C. 登録日 2022-12-30 公開日 2023-12-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023

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